Product image of Lacosamide Fresenius Kabi (Lacosamide) supplied by GNH India

Lacosamide Fresenius Kabi

Active Ingredient:
Lacosamide
Origin:
EU

Lacosamide Fresenius Kabi (Lacosamide)

Lacosamide, the active ingredient in Lacosamide Fresenius Kabi, is an anticonvulsant presented as an intravenous solution for intravenous use. It treats partial‑onset seizures and is used as adjunctive therapy in epilepsy.

GNH India supplies Lacosamide Fresenius Kabi as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Fresenius Kabi Polska Sp. Z O.O.

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Indications & Clinical Uses

  • Lacosamide is an anticonvulsant indicated for specific seizure types and epilepsy management.
  • Partial‑onset seizures: Reduces seizure frequency when added to existing antiepileptic regimens.
  • Adjunctive therapy for epilepsy: Provides additional seizure control in patients not fully controlled by other medications.
  • Generalized epilepsy: May be incorporated into combination therapy to improve overall seizure management.

How It Works

  • Lacosamide enhances the slow inactivation of voltage‑gated sodium channels, stabilizing neuronal membranes and decreasing hyper‑excitability. By selectively targeting the persistent sodium current, it reduces the likelihood of repetitive neuronal firing that underlies seizure activity, without significantly affecting normal neuronal conduction.

Side Effects

Lacosamide may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Dizziness
  • Headache
  • Nausea
  • Fatigue
  • Blurred vision
  • Somnolence

Serious or Rare Side Effects

  • Cardiac arrhythmia (e.g., PR‑interval prolongation)
  • Severe skin reactions (e.g., Stevens‑Johnson syndrome)
  • Suicidal thoughts or behavior
  • Respiratory depression
  • Anaphylactic reactions
  • Elevated liver enzymes

Precautions & Warnings

  • When prescribing Lacosamide, consider the following safety measures.
  • Renal impairment: Adjust monitoring and consider dose modification.
  • Hepatic impairment: Use with caution and monitor liver function.
  • Cardiac conduction disorders: Perform baseline ECG and monitor for PR‑interval changes.
  • Concomitant CNS depressants: Assess additive sedation risk.
  • Pregnancy: Potential risk unknown; discuss benefits and risks with the patient.
  • Store at 2-8°C: Keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Lacosamide can interact with several drug classes; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Class I antiarrhythmics: May increase risk of cardiac arrhythmias.
  • Carbamazepine: Can reduce lacosamide plasma concentrations.
  • Strong CYP2C19 inhibitors (e.g., fluconazole): May raise lacosamide exposure.

Moderate Interactions (Monitor Closely)

  • Other antiepileptics (e.g., valproate): Monitor seizure control efficacy.
  • Alcohol: May enhance central nervous system depression.
  • Warfarin: Monitor INR for potential anticoagulant effect changes.

Frequently Asked Questions

Lacosamide Fresenius Kabi is an intravenous anticonvulsant indicated for the treatment of partial‑onset seizures and as adjunctive therapy in patients with epilepsy who require additional seizure control.

Lacosamide enhances the slow inactivation of voltage‑gated sodium channels, which stabilizes neuronal membranes and reduces hyper‑excitability, thereby decreasing the likelihood of seizure generation.

The prescribed dose of Lacosamide Fresenius Kabi is determined by the treating physician based on the patient’s clinical condition, response, and any relevant laboratory parameters.

The safety of lacosamide in pregnancy and lactation has not been fully established. Clinicians should weigh potential benefits against unknown risks and discuss options with the patient.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and import documentation.

Lacosamide’s unique mechanism—enhancing slow sodium channel inactivation—differs from many traditional antiepileptics that target fast inactivation. This can provide additive seizure control when combined with other agents, often with a distinct side‑effect profile.

Lacosamide Fresenius Kabi should be stored at 2‑8 °C, kept refrigerated, protected from light, and must not be frozen or shaken vigorously to maintain solution stability.

The product is supplied as an intravenous solution and is administered by slow infusion under the supervision of qualified healthcare professionals, following the prescribing information.

Serious risks include cardiac arrhythmias such as PR‑interval prolongation, severe skin reactions (e.g., Stevens‑Johnson syndrome), suicidal thoughts or behaviors, respiratory depression, and rare cases of anaphylaxis.

Patients with known hypersensitivity to lacosamide or any component of the formulation, those with significant cardiac conduction disorders without appropriate monitoring, and individuals for whom the prescriber determines the risks outweigh the benefits should avoid using this medication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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