Product image of Lacosamide Genepharm (Lacosamide) supplied by GNH India

Lacosamide Genepharm

Active Ingredient:
Lacosamide
Origin:
EU

Lacosamide Genepharm (Lacosamide)

Lacosamide, the active ingredient in Lacosamide Genepharm, is an anticonvulsant presented as an oral formulation for oral use. It treats partial‑onset seizures and epilepsy in patients requiring seizure control.

GNH India supplies Lacosamide Genepharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Genepharm S.A.

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Indications & Clinical Uses

Lacosamide is an anticonvulsant used in the management of seizure disorders, particularly focal epilepsies.

  • Partial‑onset seizures: reduces the frequency of seizures in patients with focal epilepsy.
  • Focal epilepsy: improves overall seizure control when used as adjunct therapy.
  • Refractory epilepsy: offers an additional option for patients whose seizures are not controlled by first‑line agents.

How It Works

  • Lacosamide enhances the slow inactivation of voltage‑gated sodium channels in neuronal membranes, stabilizing hyperexcitable neuronal membranes and decreasing repetitive neuronal firing. This modulation lowers neuronal excitability, thereby helping to prevent the initiation and propagation of seizure activity.

Side Effects

Lacosamide may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Dizziness: sensation of light‑headedness or unsteadiness.
  • Nausea: mild to moderate stomach upset.
  • Headache: recurrent or persistent head pain.
  • Fatigue: increased tiredness or lack of energy.

Serious or Rare Side Effects

  • Cardiac arrhythmia: abnormal heart rhythm, especially PR‑interval prolongation.
  • Suicidal thoughts: emergence of depressive symptoms or suicidal ideation.
  • Severe skin reactions: such as Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Elevated liver enzymes: indicating possible hepatic stress.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Renal impairment: assess kidney function and adjust dose if necessary.
  • Hepatic impairment: monitor liver function tests regularly.
  • Cardiac conduction disorders: obtain baseline ECG and monitor PR interval.
  • Pregnancy: risk unknown; use only if potential benefit justifies the potential risk.
  • Concomitant antiepileptics: monitor for additive CNS depression.
  • Store below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Lacosamide can interact with other medicines; some require avoidance while others need close monitoring.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase lacosamide plasma levels.
  • Strong CYP3A4 inducers (e.g., carbamazepine): may reduce lacosamide efficacy.
  • Other sodium‑channel blockers (e.g., phenytoin): risk of additive cardiac effects.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: possible reduction in contraceptive effectiveness.
  • Alcohol: may enhance CNS depression.
  • Antidepressants (e.g., SSRIs): monitor for increased dizziness or sedation.
  • Antihypertensives: observe for potential blood pressure changes.

Frequently Asked Questions

Lacosamide Genepharm is an oral anticonvulsant indicated for the treatment of partial‑onset seizures and as adjunct therapy in focal epilepsy. It helps reduce seizure frequency and improve overall seizure control in patients with epilepsy.

Lacosamide enhances the slow inactivation of voltage‑gated sodium channels, stabilizing neuronal membranes and decreasing repetitive neuronal firing. This reduces neuronal excitability, which helps prevent the initiation and spread of seizure activity.

The appropriate dose of Lacosamide Genepharm is determined by a qualified prescriber based on the individual’s clinical condition, response, and any relevant laboratory values. Patients should follow the dosing instructions provided by their healthcare professional.

The safety of lacosamide in pregnancy and lactation has not been fully established. It should be used only if the potential benefit justifies any potential risk to the fetus or infant, and the decision should be made in consultation with a healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Lacosamide’s unique mechanism—enhancing slow sodium‑channel inactivation—differs from many traditional antiepileptics that target fast inactivation. This can provide an alternative for patients who have inadequate response or intolerable side effects with other agents, though individual response varies.

Lacosamide Genepharm should be stored below 25 °C in its original packaging, protected from moisture and direct sunlight. Keep the product out of reach of children and avoid exposure to extreme temperatures.

The medication is taken orally, usually as a tablet or oral solution, as directed by a healthcare professional. It can be taken with or without food, but consistency with regard to meals may help maintain stable absorption.

Serious risks include cardiac conduction abnormalities such as PR‑interval prolongation, potential suicidal thoughts or behavior, severe skin reactions like Stevens‑Johnson syndrome, and significant liver enzyme elevations. Patients should report any unusual symptoms promptly.

Patients with known hypersensitivity to lacosamide or any of its excipients, those with severe cardiac conduction disorders, or individuals for whom the prescriber determines the risks outweigh the benefits should avoid using this medication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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