Product image of Lacosamide Glenmark (Lacosamide) supplied by GNH India

Lacosamide Glenmark

Active Ingredient:
Lacosamide
Origin:
EU

Lacosamide Glenmark (Lacosamide)

Lacosamide, the active ingredient in Lacosamide Glenmark, is an antiepileptic presented as an oral tablet for oral use. It treats partial‑onset seizures in adults and children. GNH India supplies Lacosamide Glenmark as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Glenmark Pharmaceuticals S.R.O.

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Indications & Clinical Uses

Lacosamide is an antiepileptic indicated for the treatment of partial‑onset seizures.

  • Partial‑onset seizures: reduces seizure frequency as adjunctive therapy.
  • Focal seizures: provides additional seizure control when combined with other antiepileptics.
  • Epilepsy (partial seizures): improves overall seizure management in patients with refractory epilepsy.

How It Works

  • Lacosamide enhances the slow inactivation of voltage‑gated sodium channels, stabilizing neuronal membranes and limiting repetitive firing. It also binds to collapsin response mediator protein‑2 (CRMP2), modulating neuronal excitability and contributing to its anticonvulsant effect in the central nervous system.

Side Effects

Lacosamide may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Dizziness: sensation of light‑headedness or unsteadiness.
  • Nausea: feeling of stomach upset or urge to vomit.
  • Fatigue: unusual tiredness or lack of energy.
  • Headache: mild to moderate pain in the head.
  • Blurred vision: temporary visual disturbances.
  • Diplopia: double vision.

Serious or Rare Side Effects

  • Suicidal thoughts: emergence of depressive symptoms or suicidal ideation.
  • Severe skin reactions: such as Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Cardiac arrhythmias: irregular heart rhythms, including atrial fibrillation.
  • Severe allergic reactions: anaphylaxis or angioedema.
  • Liver injury: signs of hepatitis or elevated liver enzymes.
  • Respiratory depression: difficulty breathing, especially with concomitant CNS depressants.

Precautions & Warnings

Before initiating therapy, clinicians should evaluate patient‑specific factors and monitor for potential risks.

  • Renal impairment: adjust dosing in patients with reduced kidney function.
  • Hepatic impairment: use caution and consider dose modification in liver disease.
  • Cardiac conduction disorders: monitor ECG for PR‑interval prolongation.
  • Concomitant antiepileptics: assess for additive CNS effects.
  • Pregnancy and lactation: weigh benefits against potential unknown risks.
  • Store at ambient temperature: keep below 25 °C, retain original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Lacosamide can interact with several medicines, altering its efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): increase lacosamide plasma levels.
  • Carbamazepine: enzyme induction may reduce lacosamide concentrations.
  • Other sodium‑channel blockers: heightened risk of CNS depression.

Moderate Interactions (Monitor Closely)

  • Valproate: may affect seizure control when combined.
  • Oral contraceptives: potential reduction in hormonal efficacy.
  • Antihypertensives: possible additive blood pressure lowering effects.

Frequently Asked Questions

Lacosamide Glenmark is prescribed as an adjunctive therapy for the treatment of partial‑onset (focal) seizures in patients with epilepsy. It helps reduce the frequency and severity of seizure episodes when used alongside other antiepileptic medications.

Lacosamide works by enhancing the slow inactivation of voltage‑gated sodium channels, which stabilizes neuronal membranes and limits repetitive firing. Additionally, it binds to CRMP2, a protein involved in neuronal excitability, further contributing to its anticonvulsant activity.

The dosage of Lacosamide Glenmark is individualized by the prescribing healthcare professional based on the patient’s age, weight, renal and hepatic function, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

The safety of lacosamide in pregnancy and lactation has not been fully established. Healthcare providers must weigh the potential benefits against possible risks to the fetus or infant and consider alternative treatments when appropriate.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Lacosamide’s unique mechanism—enhancing slow sodium‑channel inactivation and targeting CRMP2—differs from many traditional antiepileptics that primarily affect fast inactivation. This can offer an alternative for patients who have not achieved adequate seizure control with other agents, though efficacy and tolerability vary among individuals.

Store the tablets at ambient temperature, preferably below 25 °C. Keep them in the original container, protect from moisture and direct sunlight, and ensure they are out of reach of children.

Lacosamide Glenmark is taken orally, usually with or without food, as directed by the prescriber. The tablets should be swallowed whole with water and not chewed or crushed unless specifically instructed.

Serious risks include the potential for suicidal thoughts or behavior, severe skin reactions such as Stevens‑Johnson syndrome, cardiac arrhythmias (including atrial fibrillation), and rare cases of liver injury. Patients should seek immediate medical attention if they experience any of these symptoms.

Lacosamide is contraindicated in patients with known hypersensitivity to the drug or any of its excipients. Caution is also advised for individuals with significant cardiac conduction abnormalities, severe renal or hepatic impairment, and those taking interacting medications that could increase toxicity.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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