Product image of Lacosamide Glenmark (Lacosamide) supplied by GNH India

Lacosamide Glenmark

Active Ingredient:
Lacosamide
Origin:
EU

Lacosamide Glenmark (Lacosamide)

Lacosamide, the active ingredient in Lacosamide Glenmark, is an anti‑epileptic presented as an oral tablet for oral use. It treats partial‑onset seizures as adjunctive therapy in patients with epilepsy.

GNH India supplies Lacosamide Glenmark as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Glenmark Pharmaceuticals S.R.O.

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Indications & Clinical Uses

Lacosamide is an anti‑seizure medication used in the management of focal epilepsy and related conditions.

  • Partial‑onset seizures: reduces seizure frequency when added to existing antiepileptic regimens.
  • Adjunctive therapy for epilepsy: improves overall seizure control in patients not fully controlled by other drugs.
  • Focal epilepsy: provides additional seizure reduction as part of combination therapy.

How It Works

  • Lacosamide enhances the slow inactivation of voltage‑gated sodium channels, stabilizing neuronal membranes and limiting repetitive firing. It also binds to the collapsin response mediator protein‑2 (CRMP2), influencing neuronal excitability. These actions collectively reduce the propagation of epileptic discharges without affecting normal neuronal activity.

Side Effects

Lacosamide may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Dizziness: transient sensation of light‑headedness.
  • Nausea: mild to moderate stomach upset.
  • Headache: occasional throbbing pain.
  • Fatigue: feeling unusually tired.
  • Blurred vision: temporary visual disturbance.
  • Diplopia: double vision in some patients.

Serious or Rare Side Effects

  • Suicidal thoughts: emergence of depressive or suicidal ideation.
  • Severe skin reactions: such as Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Cardiac conduction abnormalities: PR‑interval prolongation or arrhythmia.
  • Severe allergic reactions: anaphylaxis or angioedema.
  • Hepatic injury: signs of liver dysfunction including jaundice.

Precautions & Warnings

When prescribing lacosamide, clinicians should consider several safety aspects.

  • Renal impairment: adjust dose based on renal function.
  • Hepatic impairment: monitor liver enzymes and consider dose modification.
  • Cardiac conduction disorders: obtain baseline ECG and monitor PR interval.
  • Pregnancy: risk unknown; use only if potential benefit justifies the risk.
  • Concomitant sodium‑channel blockers: may increase central nervous system effects.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Lacosamide can interact with a variety of medicines, requiring careful management.

Major Interactions (Avoid)

  • Other sodium‑channel antiepileptics (e.g., carbamazepine, phenytoin): may increase toxicity.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): can raise lacosamide plasma levels.
  • Strong CYP3A4 inducers (e.g., rifampicin): may reduce lacosamide effectiveness.

Moderate Interactions (Monitor Closely)

  • Alcohol: may enhance central nervous system depression.
  • Other antiepileptic drugs (e.g., valproate): may require dose adjustments.
  • Anticoagulants (e.g., warfarin): may alter INR and bleeding risk.

Frequently Asked Questions

Lacosamide Glenmark is used as an adjunctive treatment for partial‑onset (focal) seizures in patients with epilepsy. It is added to existing antiepileptic regimens to help reduce the frequency and severity of seizure episodes when monotherapy does not provide adequate control.

Lacosamide works by enhancing the slow inactivation of voltage‑gated sodium channels, which stabilizes neuronal membranes and limits repetitive firing. Additionally, it modulates the CRMP2 protein, further reducing neuronal excitability and helping to prevent the spread of epileptic activity.

The specific dose of Lacosamide Glenmark is determined by the prescribing clinician based on the patient’s age, weight, renal and hepatic function, and response to therapy. Dosage adjustments are individualized, and patients should follow the prescriber’s instructions without self‑adjusting the amount.

The safety of Lacosamide during pregnancy and lactation has not been fully established. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.

To order Lacosamide Glenmark, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Lacosamide is distinct for its selective enhancement of slow sodium‑channel inactivation, which may offer better tolerability compared with traditional sodium‑channel blockers that affect fast inactivation. It is often chosen as an add‑on therapy when patients need additional seizure control without significant drug‑drug interactions.

Lacosamide Glenmark tablets should be stored at temperatures below 25 °C, in the original packaging, and protected from moisture and direct sunlight. Keeping the product in a dry, cool environment helps maintain its stability and potency throughout its shelf life.

Lacosamide Glenmark is administered orally as a tablet. Patients should swallow the tablet whole with water, typically once or twice daily as directed by their prescriber. The exact schedule depends on the individual treatment plan and should be followed precisely.

Serious risks include the potential for suicidal thoughts or behavior, severe skin reactions such as Stevens‑Johnson syndrome, cardiac conduction abnormalities like PR‑interval prolongation, and rare cases of liver injury. Patients should be monitored closely for any of these signs and report them immediately to a healthcare provider.

Lacosamide Glenmark should be avoided in patients with known hypersensitivity to lacosamide or any of its excipients, and in individuals with significant cardiac conduction disorders (e.g., advanced AV block) unless a pacemaker is present. It is also contraindicated in patients taking medications that cause severe, uncontrolled interactions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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