Product image of Lacosamide Hikma (Lacosamide) supplied by GNH India

Lacosamide Hikma

Active Ingredient:
Lacosamide
Origin:
EU

Lacosamide Hikma (Lacosamide)

Lacosamide, the active ingredient in Lacosamide Hikma, is an anticonvulsant presented as a intravenous solution for intravenous use. It treats partial‑onset seizures and is used as adjunctive therapy for epilepsy in patients who require additional seizure control.

GNH India supplies Lacosamide Hikma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Hikma Farmacêutica (Portugal), S.A.

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Indications & Clinical Uses

Lacosamide is an anticonvulsant indicated for seizure disorders.

  • Partial‑onset seizures: Reduces seizure frequency when added to existing antiepileptic regimens.
  • Adjunctive therapy for epilepsy: Provides additional seizure control in patients not fully managed by other medications.
  • Focal seizures (including secondary generalization): Helps control seizures that originate from a focal brain region.

How It Works

  • Lacosamide enhances the slow inactivation of voltage‑gated sodium channels, stabilizing hyperexcitable neuronal membranes and limiting repetitive neuronal firing. It may also bind to the collapsin response mediator protein‑2 (CRMP‑2), contributing to its antiepileptic effect without affecting fast channel inactivation.

Side Effects

Adverse reactions have been reported with intravenous lacosamide.

Common Side Effects

  • Dizziness
  • Nausea
  • Fatigue
  • Headache

Serious or Rare Side Effects

  • Cardiac arrhythmias (e.g., PR‑interval prolongation)
  • Severe skin reactions such as Stevens‑Johnson syndrome
  • Respiratory depression

Precautions & Warnings

Use of Lacosamide Hikma requires careful clinical assessment.

  • Renal impairment: Monitor renal function and adjust therapy as needed.
  • Hepatic impairment: Use with caution; consider liver function monitoring.
  • Cardiac conduction disorders: Obtain baseline ECG and observe for PR‑interval changes.
  • Concomitant CNS depressants: May increase sedation; monitor patient responsiveness.
  • Pregnancy: Safety not established; weigh potential benefits against risks.
  • Store at 2‑8°C: Keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Lacosamide may interact with several medications.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): May increase lacosamide levels.
  • Strong CYP3A4 inducers (e.g., carbamazepine): May reduce lacosamide exposure.
  • Other sodium‑channel blockers (e.g., phenytoin): Additive effect on neuronal excitability.
  • Drugs that prolong PR interval (e.g., beta‑blockers): Risk of cardiac conduction delay.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: May reduce hormonal efficacy.
  • Alcohol: Potentially enhanced CNS depression.
  • Antiplatelet agents: Observe for increased bleeding tendency.

Frequently Asked Questions

Lacosamide Hikma is an intravenous antiepileptic medication used to treat partial‑onset seizures and as adjunctive therapy for patients with epilepsy who need additional seizure control beyond their current regimen.

Lacosamide enhances the slow inactivation of voltage‑gated sodium channels, which stabilizes hyperexcitable neuronal membranes and reduces repetitive firing. This action helps to prevent the spread of seizure activity in the brain.

The specific dose and infusion rate of Lacosamide Hikma are determined by the prescribing clinician based on the patient’s clinical condition, age, weight, renal and hepatic function, and response to therapy.

Safety data for lacosamide in pregnancy and lactation are limited. The medication should only be used if the potential benefit justifies any possible risk to the fetus or infant, and decisions should be made in consultation with a healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and necessary import documentation.

Lacosamide’s unique mechanism—enhancing slow sodium‑channel inactivation—differs from many traditional antiepileptics that target fast inactivation. This can provide additive seizure control when combined with other agents, and it is generally well‑tolerated, though individual response varies.

Lacosamide Hikma should be stored at 2‑8 °C in a refrigerator, protected from light, and must not be frozen or shaken. Keep the solution in its original packaging until use to maintain stability.

The product is supplied as an intravenous solution and is administered by slow infusion under the supervision of a qualified healthcare professional, following the dosing schedule prescribed by the treating physician.

Serious risks include cardiac conduction abnormalities such as PR‑interval prolongation, severe skin reactions like Stevens‑Johnson syndrome, and respiratory depression. Patients should be monitored closely for these events, especially during initiation and dose adjustments.

Lacosamide Hikma is contraindicated in patients with known hypersensitivity to lacosamide or any component of the formulation, and it should be used with caution in individuals with significant cardiac conduction disorders, severe renal or hepatic impairment, or those taking interacting medications.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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