Product image of Lacosamide Krka (Lacosamide) supplied by GNH India

Lacosamide Krka

Active Ingredient:
Lacosamide
Origin:
EU

Lacosamide Krka (Lacosamide)

Lacosamide, the active ingredient in Lacosamide Krka, is an anticonvulsant presented as an oral dosage form for oral use. It is indicated for the treatment of partial‑onset seizures and is used as adjunctive therapy in patients with epilepsy.
GNH India supplies Lacosamide Krka as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

  • Lacosamide is an antiepileptic drug that targets neuronal excitability in seizure disorders.
  • Partial‑onset seizures: reduces seizure frequency when added to existing therapy.
  • Adjunctive therapy for epilepsy: improves overall seizure control in combination with other antiepileptic agents.
  • Focal seizures: helps manage seizures originating from a specific brain region.

How It Works

  • Lacosamide enhances the slow inactivation of voltage‑gated sodium channels in neuronal membranes, which stabilizes hyper‑excitable neuronal membranes and diminishes repetitive firing. By selectively targeting this channel state, the drug reduces neuronal hyperexcitability without affecting normal rapid sodium channel activity, contributing to seizure control.

Side Effects

Lacosamide may cause a range of adverse reactions. Patients should be informed of both common and serious possibilities.

Common Side Effects

  • Dizziness
  • Headache
  • Nausea
  • Fatigue
  • Blurred vision
  • Somnolence

Serious or Rare Side Effects

  • PR‑interval prolongation or other cardiac conduction abnormalities
  • Suicidal thoughts or behavior
  • Severe skin reactions such as Stevens‑Johnson syndrome
  • Hypersensitivity reactions including rash and angioedema
  • Elevated liver enzymes
  • Respiratory depression in susceptible individuals

Precautions & Warnings

When prescribing Lacosamide, clinicians should consider several safety aspects.

  • Renal impairment: monitor renal function and adjust therapy as needed.
  • Hepatic impairment: use with caution and observe liver function tests.
  • Concomitant antiepileptic drugs: assess for possible pharmacokinetic interactions.
  • History of cardiac conduction disorders: obtain baseline ECG and monitor periodically.
  • Pregnancy: safety data are limited; discuss potential risks with the patient.
  • Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Lacosamide can interact with several medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Carbamazepine: may lower lacosamide plasma concentrations.
  • Phenytoin: can reduce lacosamide effectiveness.
  • Strong CYP2C19 inhibitors (e.g., fluconazole): may increase lacosamide exposure.

Moderate Interactions (Monitor Closely)

  • Alcohol: may enhance central nervous system depression.
  • Other sodium‑channel blockers (e.g., lamotrigine): additive effects on cardiac conduction.
  • Hormonal contraceptives: potential alteration of contraceptive efficacy.

Frequently Asked Questions

Lacosamide Krka is used as an adjunctive antiepileptic medication to treat partial‑onset (focal) seizures in patients with epilepsy. It is prescribed when seizure control is not adequate with a single agent, helping to reduce the frequency and severity of seizure episodes.

Lacosamide works by enhancing the slow inactivation of voltage‑gated sodium channels in neurons. This stabilizes hyper‑excitable neuronal membranes, limits repetitive firing, and thereby reduces the likelihood of seizure generation without significantly affecting normal rapid sodium channel activity.

The dosage of Lacosamide Krka is individualized by the prescribing clinician based on the patient’s age, weight, renal function, and response to therapy. The prescriber determines the starting dose and any titration schedule according to approved labeling and clinical judgment.

Safety data for Lacosamide Krka in pregnancy and lactation are limited. The product should only be used if the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss risks with their healthcare provider.

To order Lacosamide Krka, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Compared with older sodium‑channel blockers such as carbamazepine, lacosamide selectively enhances slow inactivation of sodium channels, which may result in a different side‑effect profile and fewer drug‑interaction concerns. It is often chosen when patients need additional seizure control without the enzyme‑inducing properties of some alternatives.

Lacosamide Krka should be stored at temperatures below 25 °C in its original packaging. Protect the product from moisture, excessive heat, and direct sunlight. Do not store in a bathroom or near a kitchen sink where humidity is high.

Lacosamide Krka is administered orally. The tablet should be swallowed whole with a glass of water and may be taken with or without food, according to the prescriber’s instructions. Consistency in administration timing helps maintain stable drug levels.

Serious risks include cardiac conduction abnormalities such as PR‑interval prolongation, which may lead to arrhythmias, as well as rare but severe skin reactions (e.g., Stevens‑Johnson syndrome) and the emergence of suicidal thoughts or behavior. Patients should be monitored closely for these events.

Lacosamide Krka should be avoided in individuals with known hypersensitivity to lacosamide or any of its excipients, and in patients with severe cardiac conduction disorders (e.g., advanced atrioventricular block) unless under specialist supervision. Caution is also advised for patients with significant renal or hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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