Product image of Lacosamide Krka (Lacosamide) supplied by GNH India

Lacosamide Krka

Active Ingredient:
Lacosamide
Origin:
EU

Lacosamide Krka (Lacosamide)

Lacosamide, the active ingredient in Lacosamide Krka, is an anti‑epileptic drug presented as an oral tablet for oral use. It treats partial‑onset (focal) seizures in patients with epilepsy by stabilizing neuronal firing.

GNH India supplies Lacosamide Krka as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product complies with EU pharmacopeial standards and undergoes rigorous quality control.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

  • Lacosamide is an anticonvulsant indicated for the management of focal seizure disorders, where it is used as an add‑on therapy.
  • Partial‑onset seizures: reduces seizure frequency in patients with epilepsy when added to existing therapy.
  • Focal seizures: provides adjunctive control for patients who continue to have seizures despite monotherapy.
  • Epilepsy (partial seizures): used as an add‑on treatment to improve overall seizure management.

How It Works

  • Lacosamide enhances the slow inactivation of voltage‑gated sodium channels, thereby limiting repetitive neuronal firing. It also binds to collapsin response mediator protein‑2 (CRMP2), modulating neuronal excitability and contributing to its anticonvulsant effect.

Side Effects

The most frequently reported adverse reactions with lacosamide are generally mild to moderate in intensity.

Common Side Effects

  • Dizziness
  • Fatigue
  • Nausea
  • Headache
  • Blurred vision
  • Diplopia

Serious or Rare Side Effects

  • Cardiac conduction abnormalities such as PR‑interval prolongation
  • Suicidal ideation or behavior
  • Severe skin reactions including Stevens‑Johnson syndrome
  • Hypersensitivity reactions such as anaphylaxis

Precautions & Warnings

Lacosamide requires careful assessment of patient‑specific factors before initiation.

  • Renal impairment: dose may need adjustment based on renal function.
  • Hepatic impairment: monitor liver enzymes and consider dose modification.
  • Cardiac conduction disorders: perform ECG monitoring in patients with known cardiac disease.
  • Pregnancy: risk unknown; use only if potential benefit justifies the risk.
  • Concomitant CNS depressants: may increase sedation and coordination impairment.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Lacosamide may interact with several medicines, necessitating monitoring or avoidance.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., carbamazepine, phenytoin) may reduce lacosamide plasma levels – avoid co‑administration.
  • Drugs that prolong PR interval (e.g., quinidine, amiodarone) may increase risk of cardiac conduction delay – avoid.

Moderate Interactions (Monitor Closely)

  • Other antiepileptic drugs may increase CNS depression – monitor patient for excessive sedation.
  • Hormonal contraceptives may have reduced efficacy – consider alternative contraception methods.
  • Alcohol consumption may enhance dizziness and coordination impairment – advise caution.

Frequently Asked Questions

Lacosamide Krka is an oral anti‑epileptic medication indicated as an adjunctive therapy for partial‑onset (focal) seizures in patients with epilepsy. It helps reduce seizure frequency when added to existing antiepileptic regimens.

Lacosamide works by enhancing the slow inactivation of voltage‑gated sodium channels, which limits repetitive neuronal firing. It also modulates the protein CRMP2, further stabilizing neuronal excitability and contributing to seizure control.

The appropriate dose of Lacosamide Krka is determined by the prescribing clinician based on the individual’s medical condition, response to therapy, and any relevant renal or hepatic considerations. Patients should follow the prescriber’s instructions exactly.

Safety data for lacosamide in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made in consultation with a healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lacosamide’s unique mechanism—enhancing slow sodium‑channel inactivation and modulating CRMP2—differs from many traditional anticonvulsants that target fast inactivation. This can offer an alternative for patients who have not achieved adequate control with other agents, though individual response varies.

Lacosamide Krka tablets should be stored at temperatures below 25 °C, in the original packaging, and protected from moisture and direct sunlight. Keep the product out of reach of children and do not use after the expiry date.

Lacosamide Krka is taken orally, usually with or without food, as directed by the prescriber. The tablets are swallowed whole with a glass of water and should be taken at the same times each day to maintain consistent blood levels.

Serious risks include cardiac conduction abnormalities such as PR‑interval prolongation, potential suicidal thoughts or behavior, severe skin reactions like Stevens‑Johnson syndrome, and rare hypersensitivity reactions. Patients should seek immediate medical attention if they experience any of these symptoms.

Lacosamide is contraindicated in patients with known hypersensitivity to the drug or any of its excipients. Caution is also advised for individuals with significant cardiac conduction disorders, severe renal or hepatic impairment, and those taking medications that markedly affect its metabolism.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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