Product image of Lacosamide Stada (Lacosamide) supplied by GNH India

Lacosamide Stada

Active Ingredient:
Lacosamide
Origin:
EU

Lacosamide Stada (Lacosamide)

Lacosamide, the active ingredient in Lacosamide Stada, is an anticonvulsant presented as an oral dosage form for oral use. It is indicated for the treatment of partial‑onset seizures in patients with epilepsy.
GNH India supplies Lacosamide Stada as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Stada Arzneimittel Ag

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Indications & Clinical Uses

  • Lacosamide Stada is an antiepileptic drug that acts on neuronal sodium channels to control seizure activity.
  • Partial‑onset seizures: reduces the frequency of focal seizures when used as adjunct therapy.
  • Epilepsy: helps achieve better overall seizure control in patients with epilepsy.
  • Adjunctive therapy for refractory epilepsy: provides additional seizure reduction when first‑line agents are insufficient.

How It Works

  • Lacosamide selectively enhances the slow inactivation phase of voltage‑gated sodium channels in neuronal membranes. By stabilising the channels in an inactive state, it limits repetitive neuronal firing and diminishes hyper‑excitability that underlies seizure generation, offering a distinct mechanism from agents that target fast inactivation.

Side Effects

Lacosamide may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Dizziness
  • Fatigue
  • Nausea
  • Headache
  • Blurred vision
  • Diplopia

Serious or Rare Side Effects

  • PR‑interval prolongation or other cardiac conduction abnormalities
  • Severe skin reactions such as Stevens‑Johnson syndrome
  • Suicidal thoughts or behavior
  • Hypersensitivity reactions including anaphylaxis
  • Elevated liver enzymes
  • Severe respiratory depression when combined with other CNS depressants

Precautions & Warnings

Before initiating therapy, clinicians should evaluate patient‑specific factors and monitor for potential complications.

  • Renal impairment: assess renal function and adjust dose if necessary.
  • Hepatic impairment: monitor liver enzymes and consider dose modification.
  • Cardiac conduction disorders: obtain baseline ECG and monitor PR interval.
  • Pregnancy: risk unknown; discuss benefits versus risks with the patient.
  • Concomitant CNS depressants: observe for enhanced sedation or respiratory depression.
  • Store at ambient temperature: keep below 25 °C in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Lacosamide can interact with several medicines, requiring careful management.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase lacosamide plasma levels.
  • Drugs that prolong PR interval (e.g., class IA antiarrhythmics): risk of additive cardiac conduction effects.

Moderate Interactions (Monitor Closely)

  • Carbamazepine: may reduce lacosamide efficacy.
  • Phenytoin: may increase risk of dizziness and ataxia.
  • Alcohol or other CNS depressants: monitor for enhanced sedation.
  • Certain antidepressants (e.g., SSRIs): watch for increased side‑effect burden.

Frequently Asked Questions

Lacosamide Stada is a prescription antiepileptic medication indicated for the treatment of partial‑onset (focal) seizures in patients with epilepsy. It is used as adjunct therapy to reduce seizure frequency and improve overall seizure control when combined with other antiseizure medicines.

Lacosamide enhances the slow inactivation of voltage‑gated sodium channels in neuronal membranes. By stabilising the inactive state of these channels, it reduces repetitive neuronal firing and diminishes hyper‑excitability that leads to seizure activity. This mechanism differs from traditional sodium‑channel blockers that target fast inactivation.

The specific dose of Lacosamide Stada is determined by the prescribing clinician based on the patient’s age, weight, renal function, and concomitant therapies. The prescriber will start with a low dose and may titrate upward to achieve optimal seizure control while monitoring tolerability.

The safety of lacosamide during pregnancy and lactation has not been fully established. It is classified as pregnancy category unknown, and the potential benefits must be weighed against possible risks. Women who are pregnant, planning pregnancy, or nursing should discuss treatment options with their healthcare provider.

To request Lacosamide Stada, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will verify trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Compared with older sodium‑channel blockers such as carbamazepine, lacosamide selectively enhances slow inactivation, which may result in a different side‑effect profile and lower risk of certain drug‑induced arrhythmias. It is often used when patients require additional seizure control or cannot tolerate alternative agents.

Store at ambient temperature, below 25 °C, in the original packaging. Keep the product away from moisture and direct sunlight. Do not refrigerate or freeze the tablets, and keep them out of reach of children.

Lacosamide Stada is taken orally, usually as a tablet, with or without food. The medication should be swallowed whole with a glass of water. Patients should follow the dosing schedule prescribed by their clinician and not alter the regimen without medical advice.

Serious adverse reactions can include cardiac conduction abnormalities such as PR‑interval prolongation, severe skin reactions (e.g., Stevens‑Johnson syndrome), suicidal thoughts or behavior, and hypersensitivity reactions. Prompt medical attention is required if any of these events occur.

Lacosamide Stada should be avoided in patients with known hypersensitivity to lacosamide or any of its excipients, and in individuals with significant cardiac conduction disorders unless closely monitored. Caution is also advised for patients with severe renal or hepatic impairment, and it should be prescribed only after a thorough clinical assessment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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