Product image of Lacosamide Strides (Lacosamide) supplied by GNH India

Lacosamide Strides

Active Ingredient:
Lacosamide
Origin:
EU

Lacosamide Strides (Lacosamide)

Lacosamide, the active ingredient in Lacosamide Strides, is an anticonvulsant presented as an oral tablet for oral use. It treats partial‑onset seizures and broader epilepsy syndromes in both adult and pediatric patients requiring adjunctive therapy. It is indicated for patients whose seizures are not adequately controlled by other antiepileptic drugs.

GNH India supplies Lacosamide Strides as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product meets European Union quality standards and is manufactured under strict GMP conditions.

Manufacturer / TM Owner

Strides Nordic Aps

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Indications & Clinical Uses

Lacosamide is used in the management of seizure disorders within the epilepsy therapeutic pathway.

  • Partial‑onset seizures: reduces frequency of focal seizures when added to existing therapy.
  • Focal epilepsy: provides adjunctive control of seizures originating from a specific brain region.
  • Adjunctive epilepsy therapy: improves overall seizure control in patients not fully responsive to other antiepileptics.

How It Works

  • Lacosamide selectively enhances the slow inactivation of voltage‑gated sodium channels in neuronal membranes. By stabilizing the inactive state of these channels, it diminishes repetitive neuronal firing and reduces hyper‑excitability that underlies seizure generation. This mechanism is distinct from traditional sodium‑channel blockers that affect fast inactivation, offering a complementary approach to seizure control.

Side Effects

Lacosamide may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Dizziness
  • Nausea
  • Headache
  • Fatigue

Serious or Rare Side Effects

  • Cardiac conduction abnormalities (PR interval prolongation)
  • Suicidal thoughts or behavior
  • Severe skin reactions such as Stevens‑Johnson syndrome

Precautions & Warnings

When prescribing Lacosamide, clinicians should consider several safety aspects.

  • Renal impairment: assess renal function and consider dose adjustment.
  • Hepatic impairment: monitor liver enzymes and adjust as needed.
  • Cardiac conduction disorders: obtain baseline ECG and monitor PR interval.
  • Pregnancy: risk unknown; use only if benefits outweigh potential risks.
  • Concomitant CNS depressants: monitor for enhanced sedation.
  • Store at room temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Lacosamide can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase lacosamide plasma levels.
  • Drugs that prolong PR interval (e.g., carbamazepine, quinidine): risk of cardiac conduction delay.

Moderate Interactions (Monitor Closely)

  • Other antiepileptic drugs: may require dose adjustments.
  • Alcohol: can enhance CNS depression.
  • Hormonal contraceptives: may reduce efficacy of contraceptive.

Frequently Asked Questions

Lacosamide Strides is prescribed as an adjunctive therapy for patients with partial‑onset (focal) seizures and other forms of epilepsy when seizure control is not achieved with existing antiepileptic medications.

Lacosamide enhances the slow inactivation of voltage‑gated sodium channels in neurons, stabilizing the inactive channel state and reducing repetitive firing that contributes to seizure activity.

The specific dose and titration schedule are determined by the prescribing clinician based on the patient’s age, weight, renal function, and response to therapy. No fixed regimen is provided here.

Safety data in pregnancy and lactation are limited. The product is classified as having an unknown pregnancy category, so it should only be used if the potential benefit justifies any potential risk to the fetus or infant.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lacosamide’s unique mechanism—enhancing slow sodium‑channel inactivation—differs from many traditional antiepileptics that target fast inactivation. This can provide complementary seizure control, especially in patients who have not responded adequately to other agents.

Store the oral tablets at room temperature, below 25 °C, in the original packaging. Protect them from moisture, excessive heat and direct light to maintain product stability.

Lacosamide Strides is taken orally, usually with or without food, as directed by the prescriber. Tablets should be swallowed whole with water and not crushed or chewed unless specifically instructed.

Serious concerns include cardiac conduction abnormalities such as PR‑interval prolongation, emergence of suicidal thoughts or behavior, and rare severe skin reactions like Stevens‑Johnson syndrome. Patients should be monitored for these events.

Patients with known hypersensitivity to lacosamide or any component of the formulation should avoid it. Caution is also advised for individuals with significant cardiac conduction disorders, severe renal or hepatic impairment, unless a clinician determines the benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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