Product image of Lacosamide Teva (Lacosamide) supplied by GNH India

Lacosamide Teva

Active Ingredient:
Lacosamide
Origin:
EU

Lacosamide Teva (Lacosamide)

Lacosamide, the active ingredient in Lacosamide Teva, is an anticonvulsant presented as an oral dosage form for oral use. It is employed in the treatment of partial‑onset seizures, typically as adjunctive therapy in patients with epilepsy.

GNH India supplies Lacosamide Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Lacosamide is an antiepileptic drug that acts on neuronal sodium channels to control seizure activity.

  • Partial‑onset seizures (focal seizures): reduces seizure frequency as adjunctive therapy.
  • Epilepsy (overall management): contributes to seizure control when combined with other antiepileptic medications.
  • Refractory focal epilepsy: provides an additional option for patients whose seizures are not adequately controlled by other agents.

How It Works

  • Lacosamide enhances the slow inactivation of voltage‑gated sodium channels, stabilising hyper‑excitable neuronal membranes and limiting repetitive neuronal firing. This selective modulation reduces the propagation of epileptic discharges without markedly affecting normal neuronal activity.

Side Effects

Lacosamide may cause a range of adverse reactions, most of which are dose‑related and reversible upon discontinuation.

Common Side Effects

  • Dizziness: sensation of light‑headedness or unsteadiness.
  • Nausea: mild to moderate stomach upset.
  • Fatigue: increased tiredness or lack of energy.
  • Blurred vision: temporary visual disturbances.

Serious or Rare Side Effects

  • Cardiac conduction abnormalities: PR‑interval prolongation or arrhythmia.
  • Suicidal ideation: emergence of thoughts of self‑harm.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Respiratory depression: marked reduction in breathing effort.
  • Hepatic dysfunction: elevated liver enzymes or hepatitis.
  • Allergic reactions: anaphylaxis or severe hypersensitivity.

Precautions & Warnings

Before initiating therapy, clinicians should evaluate several safety considerations.

  • Monitor cardiac function: obtain baseline ECG and watch for PR‑interval changes.
  • Assess renal function: adjust dosing in severe renal impairment.
  • Avoid abrupt discontinuation: taper under medical supervision to prevent seizure worsening.
  • Use caution in hepatic disease: monitor liver enzymes regularly.
  • Pregnancy: risk unknown; weigh benefits against potential fetal risks.
  • Store at ambient temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Lacosamide can interact with other medicines, altering its effectiveness or safety profile.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., carbamazepine): may lower lacosamide plasma levels.
  • Concurrent sodium‑channel blockers (e.g., phenytoin): increase risk of CNS depression.
  • Drugs that prolong PR interval (e.g., verapamil): may exacerbate cardiac conduction delays.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: may experience reduced efficacy.
  • Alcohol: can enhance dizziness and sedation.
  • Antacids: generally no dose adjustment needed, but monitor symptom control.

Frequently Asked Questions

Lacosamide Teva is prescribed as an adjunctive treatment for partial‑onset (focal) seizures in patients with epilepsy. It is used when seizure control is not achieved with other antiepileptic drugs alone, helping to reduce the frequency and severity of seizure episodes.

Lacosamide selectively enhances the slow inactivation of voltage‑gated sodium channels in neuronal membranes. By stabilising hyper‑excitable neurons, it limits the repetitive firing that underlies seizure activity, thereby contributing to overall seizure control without markedly affecting normal brain function.

The specific dose of Lacosamide Teva is determined by the prescribing clinician based on the patient’s age, weight, renal function, and response to therapy. Dosage titration follows established clinical guidelines, and patients should follow the prescriber’s instructions precisely.

Safety data for lacosamide in pregnancy and lactation are limited. The medication should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Lacosamide’s unique mechanism—enhancing slow sodium‑channel inactivation—differs from many traditional antiepileptics that block fast sodium channels. This can provide additive seizure control when combined with other agents and may be better tolerated in some patients, though individual response varies and should be assessed by a neurologist.

Lacosamide Teva is administered orally, usually as a tablet taken with or without food. The prescriber will advise the exact dosing schedule, which often starts with a low dose and is gradually increased to achieve optimal seizure control while monitoring for side effects.

Serious adverse events include cardiac conduction abnormalities such as PR‑interval prolongation, severe skin reactions like Stevens‑Johnson syndrome, suicidal thoughts or behaviours, and significant hepatic dysfunction. Patients should seek immediate medical attention if they experience palpitations, rash, mood changes, or jaundice.

Lacosamide Teva is contraindicated in individuals with known hypersensitivity to lacosamide or any of its excipients. Caution is advised for patients with severe cardiac conduction disorders, significant hepatic impairment, or those taking other medications that markedly prolong the PR interval. Pregnant or breastfeeding women should only use it under strict medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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