Product image of Lacosamide Ucb (Lacosamide) supplied by GNH India

Lacosamide Ucb

Active Ingredient:
Lacosamide
Origin:
EU

Lacosamide Ucb (Lacosamide)

Lacosamide, the active ingredient in Lacosamide Ucb, is a anti‑epileptic presented as a injection for intravenous use. It treats partial‑onset seizures in patients with epilepsy.

GNH India supplies Lacosamide Ucb as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ucb Pharma S.A.

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Indications & Clinical Uses

  • Lacosamide is an anticonvulsant used in the management of seizure disorders.
  • Partial‑onset seizures: reduces seizure frequency as adjunctive therapy in epilepsy patients.
  • Epilepsy: provides additional seizure control when monotherapy is insufficient.
  • Focal seizures: improves overall seizure management as part of a combination regimen.

How It Works

  • Lacosamide enhances the slow inactivation of voltage‑gated sodium channels, stabilizing neuronal membranes and reducing hyper‑excitability. It also binds to collapsin response mediator protein‑2 (CRMP‑2), which may modulate neuronal differentiation and axonal outgrowth, contributing to its anticonvulsant effect.

Side Effects

Lacosamide may cause a range of adverse reactions, some of which are more frequent than others.

Common Side Effects

  • Dizziness
  • Nausea
  • Headache
  • Fatigue

Serious or Rare Side Effects

  • Cardiac arrhythmia, including atrioventricular block
  • Severe skin reactions such as Stevens‑Johnson syndrome
  • Hypersensitivity reactions that may require immediate medical attention

Precautions & Warnings

  • When using Lacosamide injection, several safety considerations should be observed.
  • Renal impairment: monitor dosing and plasma levels.
  • Hepatic impairment: use with caution and consider dose adjustment.
  • Concomitant cardiac drugs: observe ECG for conduction changes.
  • Pregnancy: prescribe only if potential benefit justifies the risk.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Lacosamide can interact with other medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Class I antiarrhythmics: may exacerbate cardiac conduction abnormalities.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase lacosamide plasma concentrations.
  • Strong CYP3A4 inducers (e.g., rifampin): may lower lacosamide effectiveness.

Moderate Interactions (Monitor Closely)

  • Carbamazepine: may increase risk of dizziness and somnolence.
  • Phenytoin: may alter lacosamide plasma levels.
  • Alcohol: may enhance central nervous system depression.

Frequently Asked Questions

Lacosamide Ucb is an intravenous formulation of the anti‑epileptic drug lacosamide. It is prescribed as an adjunctive treatment for patients with partial‑onset (focal) seizures associated with epilepsy, helping to reduce seizure frequency when other therapies are insufficient.

Lacosamide works by enhancing the slow inactivation of voltage‑gated sodium channels, which stabilizes neuronal membranes and limits repetitive firing. Additionally, it binds to the protein CRMP‑2, influencing neuronal development pathways that may further contribute to its anticonvulsant activity.

The specific dose and infusion rate of Lacosamide Ucb are determined by the prescribing clinician based on the patient’s clinical condition, age, renal and hepatic function, and response to therapy. Healthcare professionals should follow local prescribing guidelines and adjust as needed.

Safety data for lacosamide in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss risks with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain handling if needed), and necessary import documentation.

Lacosamide’s unique mechanism—enhancing slow sodium‑channel inactivation and binding CRMP‑2—differs from many traditional antiepileptics that target fast inactivation. This can provide additive seizure control when combined with other agents, and it may have a more favorable interaction profile compared with some enzyme‑inducing drugs.

Lacosamide Ucb should be stored at 2‑8 °C (refrigerated). Keep the vials in their original packaging, protect them from light, and avoid freezing or shaking the solution. Do not use the product if it has been exposed to temperatures outside the recommended range.

Lacosamide Ucb is administered intravenously by a healthcare professional. The infusion rate and total daily dose are individualized according to the patient’s clinical needs and are typically given over a period of minutes to hours, following the prescribing information.

Serious risks include cardiac conduction abnormalities such as atrioventricular block or other arrhythmias, severe skin reactions like Stevens‑Johnson syndrome, and hypersensitivity reactions that may be life‑threatening. Patients should be monitored for these events, especially during initiation and dose adjustments.

Lacosamide Ucb is contraindicated in patients with known hypersensitivity to lacosamide or any of the formulation excipients. Caution is also advised for individuals with significant cardiac conduction disorders, severe hepatic impairment, or those taking medications that may cause dangerous interactions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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