Product image of Lacosamide Ucb (Lacosamide) supplied by GNH India

Lacosamide Ucb

Active Ingredient:
Lacosamide
Origin:
EU

Lacosamide Ucb (Lacosamide)

Lacosamide, the active ingredient in Lacosamide Ucb, is an antiepileptic presented as an oral tablet for oral use. It is employed to treat partial‑onset seizures in patients with epilepsy, and may be used as adjunctive therapy when seizures are not adequately controlled by other medications.

GNH India supplies Lacosamide Ucb as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable sourcing for regulated markets and ensuring compliance with local regulatory requirements.

Manufacturer / TM Owner

Ucb Pharma S.A.

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Indications & Clinical Uses

Lacosamide is an antiepileptic drug indicated for specific seizure types.

  • Partial‑onset seizures: reduces the frequency of focal seizures when used alone or with other antiseizure medicines.
  • Adjunctive therapy in epilepsy: added to existing regimens to improve overall seizure control.
  • Focal seizures with secondary generalization: helps control seizures that spread from a focal origin.

How It Works

  • Lacosamide enhances the slow inactivation of voltage‑gated sodium channels, stabilizing neuronal membranes and limiting repetitive firing. It also binds to collapsin response mediator protein‑2 (CRMP‑2), which may modulate neuronal differentiation and axonal outgrowth. Through these actions, lacosamide decreases the likelihood of seizure initiation and spread in the brain.

Side Effects

Lacosamide may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Dizziness
  • Nausea
  • Headache
  • Fatigue

Serious or Rare Side Effects

  • Cardiac conduction abnormalities (e.g., PR‑interval prolongation)
  • Severe skin reactions such as Stevens‑Johnson syndrome
  • Suicidal thoughts or behavior
  • Liver function test elevations

Precautions & Warnings

When prescribing lacosamide, clinicians should consider several safety factors.

  • Renal impairment: dose may need adjustment in patients with severe renal dysfunction.
  • Hepatic impairment: monitor liver function tests regularly.
  • Cardiac disease: avoid in patients with known conduction disorders.
  • Pregnancy: safety not established; use only if benefit outweighs risk.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Lacosamide can interact with other medicines, requiring attention to the level of risk.

Major Interactions (Avoid)

  • Concomitant use with strong CYP3A4 inducers (e.g., carbamazepine, phenytoin) may markedly reduce lacosamide levels.
  • Co‑administration with drugs that prolong the PR interval (e.g., class IA antiarrhythmics) can increase the risk of cardiac conduction delay.

Moderate Interactions (Monitor Closely)

  • Combination with other antiseizure medicines may increase central nervous system depression (e.g., benzodiazepines).
  • Concurrent use with alcohol may enhance dizziness and somnolence.
  • Use with drugs affecting renal excretion (e.g., probenecid) may alter lacosamide clearance.

Frequently Asked Questions

Lacosamide Ucb is an antiepileptic medication indicated for the treatment of partial‑onset seizures and as adjunctive therapy in patients with epilepsy whose seizures are not fully controlled by other antiseizure drugs.

Lacosamide enhances the slow inactivation of voltage‑gated sodium channels, which stabilises neuronal membranes and reduces repetitive firing. It also binds to the protein CRMP‑2, influencing neuronal differentiation and axonal growth, together limiting seizure propagation.

The appropriate dose of Lacosamide Ucb is determined by the prescribing clinician based on the individual’s clinical condition, age, renal function and concomitant therapies. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for lacosamide in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made in consultation with a healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Lacosamide’s unique mechanism—enhancing slow sodium‑channel inactivation and binding CRMP‑2—differs from many older antiseizure medicines that target fast inactivation. This can offer an alternative for patients who have inadequate response or intolerable side effects with other agents, though individual response varies.

Store Lacosamide Ucb at ambient temperature, below 25 °C, in the original packaging. Keep the product away from moisture and direct light, and ensure the container is tightly closed to maintain stability.

Lacosamide Ucb is taken orally, usually as a tablet, with or without food as directed by the prescriber. The medication should be swallowed whole with water and not crushed or chewed unless specifically instructed.

Serious adverse events include cardiac conduction abnormalities such as PR‑interval prolongation or atrioventricular block, severe skin reactions like Stevens‑Johnson syndrome, suicidal thoughts or behaviors, and significant liver enzyme elevations. Patients should seek immediate medical attention if any of these occur.

Lacosamide Ucb is contraindicated in patients with known hypersensitivity to lacosamide or any of its excipients, and it should be avoided in individuals with pre‑existing severe cardiac conduction disorders unless closely monitored by a cardiologist.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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