Product image of Lacosamide Ucb (Lacosamide) supplied by GNH India

Lacosamide Ucb

Active Ingredient:
Lacosamide
Origin:
EU

Lacosamide Ucb (Lacosamide)

Lacosamide, the active ingredient in Lacosamide Ucb, is an anti‑epileptic drug presented as an oral tablet for oral use. It is indicated for the adjunctive treatment of partial‑onset seizures in patients with epilepsy.

GNH India supplies Lacosamide Ucb as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ucb Pharma S.A.

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Indications & Clinical Uses

Lacosamide is an anti‑epileptic medication used to manage seizure disorders.

  • Partial‑onset seizures: provides adjunctive seizure control in patients with epilepsy.

How It Works

  • Lacosamide enhances the slow inactivation of voltage‑gated sodium channels, stabilizing hyper‑excitable neuronal membranes. It also binds to collapsin response mediator protein‑2 (CRMP‑2), which may modulate neuronal differentiation and axonal outgrowth, contributing to its anticonvulsant effect.

Side Effects

Lacosamide may cause a range of adverse reactions.

Common Side Effects

  • Dizziness: mild vertigo or light‑headedness.
  • Nausea: upset stomach or feeling sick.
  • Fatigue: unusual tiredness.
  • Headache: mild to moderate pain.

Serious or Rare Side Effects

  • Suicidal thoughts: emergence of depressive symptoms or suicidal ideation.
  • Severe skin reactions: rash, Stevens‑Johnson syndrome.
  • Cardiac arrhythmia: irregular heartbeat or palpitations.

Precautions & Warnings

When prescribing Lacosamide, consider the following precautions.

  • Assess renal function: adjust dosing if impairment is present.
  • Monitor mood changes: watch for depression or suicidal ideation.
  • Avoid abrupt discontinuation: taper under medical supervision.
  • Use caution in hepatic impairment: evaluate liver function before initiation.
  • Store at room temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Lacosamide can interact with several medicines; awareness of the interaction level is essential.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., carbamazepine, phenytoin): may lower lacosamide plasma concentrations.
  • Other sodium‑channel blockers: increased risk of central nervous system depression.
  • QT‑prolonging agents: potential for additive cardiac arrhythmia risk.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: efficacy may be reduced, requiring additional contraceptive measures.
  • Anticoagulants (e.g., warfarin): may necessitate INR monitoring and dose adjustment.

Frequently Asked Questions

Lacosamide Ucb is used as an adjunctive therapy for the treatment of partial‑onset seizures in patients with epilepsy. It helps reduce the frequency of seizure episodes when added to existing antiepileptic regimens.

Lacosamide works by enhancing the slow inactivation of voltage‑gated sodium channels, which stabilizes neuronal membranes and reduces hyper‑excitability. Additionally, it binds to CRMP‑2, a protein involved in neuronal development, further contributing to its anticonvulsant activity.

The appropriate dose of Lacosamide is determined by the prescribing clinician based on the individual’s medical condition, response to therapy, and renal function. Patients should follow the dosage instructions provided by their healthcare professional.

Safety data for Lacosamide during pregnancy and lactation are limited. Clinicians should weigh the potential benefits against possible risks and consider alternative treatments when appropriate. Breastfeeding mothers should discuss potential exposure with their doctor.

To order Lacosamide Ucb, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Compared with older sodium‑channel blockers such as carbamazepine, Lacosamide offers a distinct mechanism by enhancing slow inactivation rather than fast inactivation. It is generally well tolerated and may be preferred when patients experience side effects from other agents, though individual response varies.

Lacosamide tablets should be stored at room temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the product out of reach of children and avoid storing in humid environments.

Lacosamide is administered orally as a tablet. Patients should swallow the tablet whole with water, preferably with or without food, as directed by their healthcare provider.

Serious risks include the emergence of suicidal thoughts or behavior, severe skin reactions such as Stevens‑Johnson syndrome, and cardiac arrhythmias. Patients should be monitored closely for mood changes, rash, or irregular heartbeats and seek immediate medical attention if these occur.

Lacosamide is contraindicated in individuals with known hypersensitivity to the drug or any of its components, and in patients with certain cardiac conduction disorders such as second‑ or third‑degree AV block without a pacemaker. Clinicians should evaluate each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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