Product image of Lacosamide Vivanta (Lacosamide) supplied by GNH India

Lacosamide Vivanta

Active Ingredient:
Lacosamide
Origin:
EU

Lacosamide Vivanta (Lacosamide)

Lacosamide, the active ingredient in Lacosamide Vivanta, is a anti‑epileptic (sodium channel blocker) presented as an intravenous solution for intravenous use. It is used as adjunctive therapy for partial‑onset seizures in adult patients.
GNH India supplies Lacosamide Vivanta as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Vivanta Generics S.R.O.

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Indications & Clinical Uses

Lacosamide is an anti‑epileptic drug that acts on neuronal sodium channels to control seizure activity.

  • Partial‑onset seizures (focal seizures): reduces seizure frequency when added to existing antiepileptic therapy.
  • Adjunctive therapy in epilepsy: provides additional seizure control for adults with refractory epilepsy.
  • Seizure management in adults: improves overall seizure control as part of combination treatment.

How It Works

  • Lacosamide selectively enhances the slow inactivation of voltage‑gated sodium channels, stabilizing hyperexcitable neuronal membranes and limiting repetitive neuronal firing. This modulation reduces the propagation of epileptic discharges without significantly affecting normal neuronal activity.

Side Effects

Lacosamide may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Dizziness: transient sensation of light‑headedness.
  • Headache: mild to moderate pain in the head region.
  • Nausea: feeling of stomach upset or urge to vomit.
  • Fatigue: unusual tiredness or lack of energy.
  • Blurred vision: temporary visual disturbances.
  • Somnolence: increased sleepiness or drowsiness.

Serious or Rare Side Effects

  • Cardiac arrhythmia: irregular heart rhythm requiring medical attention.
  • Suicidal ideation: thoughts of self‑harm that need immediate evaluation.
  • Severe skin reactions: such as Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Respiratory depression: reduced breathing effort, especially with CNS depressants.

Precautions & Warnings

Before initiating therapy, consider patient‑specific factors and monitor for potential risks.

  • Renal impairment: assess kidney function and adjust monitoring as needed.
  • Cardiac conduction disorders: obtain baseline ECG and watch for PR‑interval changes.
  • Pregnancy: safety category unknown; weigh benefits against potential risks.
  • Concomitant CNS depressants: use caution due to additive sedative effects.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Lacosamide can interact with several medications, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors: may increase lacosamide plasma concentrations.
  • Strong CYP3A4 inducers: may reduce lacosamide effectiveness.
  • Other sodium channel blockers: risk of additive central nervous system effects.

Moderate Interactions (Monitor Closely)

  • Carbamazepine: may lower lacosamide levels, reducing seizure control.
  • Phenytoin: can increase dizziness and coordination problems.
  • Alcohol: may enhance sedation and impair alertness.

Frequently Asked Questions

Lacosamide Vivanta is an intravenous anti‑epileptic medication indicated as adjunctive therapy for partial‑onset (focal) seizures in adult patients. It is prescribed when additional seizure control is needed alongside other antiepileptic drugs.

Lacosamide enhances the slow inactivation of voltage‑gated sodium channels in neuronal membranes. By stabilizing these channels, it reduces excessive neuronal firing that leads to seizures, without markedly affecting normal brain activity.

The specific dose and infusion rate of Lacosamide Vivanta are determined by the prescribing clinician based on the patient’s clinical condition, response, and any relevant laboratory values. Dosage adjustments are individualized.

The pregnancy safety category for lacosamide is unknown. Use during pregnancy or lactation only if the potential benefit justifies the potential risk to the fetus or infant, and after careful discussion with a healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Lacosamide’s unique mechanism—enhancing slow sodium‑channel inactivation—differs from many traditional agents that block fast inactivation. This can offer complementary seizure control when combined with other antiepileptics, and it may have a distinct side‑effect profile compared with drugs such as carbamazepine or levetiracetam.

Lacosamide Vivanta should be stored at 2‑8 °C in a refrigerator, protected from light. Do not freeze or shake the vial. Keep the product in its original packaging until ready for use to maintain stability.

The medication is supplied as an intravenous solution and is administered by slow infusion into a vein under the supervision of a qualified healthcare professional. The infusion rate and duration are set by the prescriber according to clinical guidelines.

Serious risks include cardiac arrhythmias such as PR‑interval prolongation, severe skin reactions like Stevens‑Johnson syndrome, and psychiatric effects including suicidal thoughts. Patients should be monitored closely for any of these events, and treatment should be discontinued if they occur.

Lacosamide Vivanta is contraindicated in patients with known hypersensitivity to lacosamide or any component of the formulation. Caution is also advised for individuals with significant cardiac conduction abnormalities, severe renal impairment, or those taking interacting medications that could increase toxicity.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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