Product image of Lacosamide Vivanta (Lacosamide) supplied by GNH India

Lacosamide Vivanta

Active Ingredient:
Lacosamide
Origin:
EU

Lacosamide Vivanta (Lacosamide)

Lacosamide, the active ingredient in Lacosamide Vivanta, is an anticonvulsant presented as an injection for intravenous use. It treats partial‑onset seizures as adjunctive therapy in patients with epilepsy.

GNH India supplies Lacosamide Vivanta as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Vivanta Generics S.R.O.

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Indications & Clinical Uses

  • Lacosamide is an anticonvulsant indicated for focal seizure disorders and is used as add‑on therapy in epilepsy.
  • Partial‑onset seizures: reduces seizure frequency when combined with other antiepileptic drugs.
  • Epilepsy (focal epilepsy): improves overall seizure control as adjunctive treatment.
  • Refractory focal epilepsy: provides additional therapeutic option for patients not fully controlled by existing regimens.

How It Works

  • Lacosamide enhances the slow inactivation of voltage‑gated sodium channels, which stabilises hyper‑excitable neuronal membranes and reduces repetitive neuronal firing. By selectively targeting the slow inactivation phase, it limits the propagation of epileptiform activity without markedly affecting normal neuronal conduction.

Side Effects

Lacosamide may cause a range of adverse reactions, from mild to severe. Awareness of these effects helps clinicians monitor patients appropriately.

Common Side Effects

  • Dizziness: transient sensation of light‑headedness.
  • Nausea: mild gastrointestinal upset.
  • Somnolence: increased sleepiness or fatigue.
  • Headache: mild to moderate cranial discomfort.

Serious or Rare Side Effects

  • Cardiac conduction abnormalities: PR‑interval prolongation or arrhythmia.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Suicidal ideation: emergence of depressive thoughts.
  • Anaphylaxis: acute hypersensitivity requiring immediate medical attention.

Precautions & Warnings

  • When prescribing Lacosamide Vivanta, clinicians should consider several safety aspects to minimise risk.
  • Renal impairment: monitor renal function and adjust therapy as needed.
  • Cardiac conduction disorders: obtain baseline ECG and observe for PR‑interval changes.
  • Pregnancy: risk unknown; use only if potential benefit justifies the risk.
  • Concomitant CNS depressants: watch for enhanced sedation or respiratory depression.
  • Hypersensitivity: discontinue immediately if allergic reaction occurs.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Lacosamide can interact with several medicines, influencing its plasma concentration or safety profile.

Major Interactions (Avoid)

  • Carbamazepine: enzyme induction reduces lacosamide levels, decreasing efficacy.
  • Phenytoin: strong inducer that lowers lacosamide concentrations.
  • Other sodium‑channel blockers (e.g., lamotrigine): may increase risk of CNS depression.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., erythromycin): raise lacosamide levels, requiring dose review.
  • Hormonal contraceptives: may have reduced effectiveness, consider alternative contraception.
  • Alcohol: can potentiate sedation and dizziness.

Frequently Asked Questions

Lacosamide Vivanta is an intravenous formulation of the anticonvulsant lacosamide. It is approved as adjunctive therapy for partial‑onset (focal) seizures in patients with epilepsy, helping to reduce seizure frequency when added to existing antiepileptic regimens.

Lacosamide enhances the slow inactivation of voltage‑gated sodium channels in neuronal membranes. This stabilises hyper‑excitable neurons, limits repetitive firing, and thereby reduces the propagation of epileptic activity without markedly affecting normal nerve conduction.

The specific dose and infusion rate of Lacosamide Vivanta are determined by the prescribing clinician based on the patient’s clinical condition, age, weight, renal function, and concomitant therapies. Healthcare professionals should follow local prescribing guidelines and adjust as needed.

The safety of lacosamide during pregnancy and lactation has not been fully established. It should be used only if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and decisions should be made in consultation with a qualified obstetrician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where applicable) and necessary import documentation.

Compared with traditional sodium‑channel blockers such as carbamazepine, lacosamide selectively enhances slow inactivation, which may result in a different side‑effect profile and fewer drug‑interaction concerns. However, therapeutic decisions depend on individual patient factors, seizure type, and tolerability.

Lacosamide Vivanta must be stored refrigerated at 2‑8 °C. Keep the vials in their original packaging, protect them from light, and avoid freezing or shaking. If the product reaches room temperature for a short period, it may still be used, but it should be returned to the refrigerator promptly.

Lacosamide Vivanta is given by intravenous infusion. The recommended infusion rate and total daily dose are set by the treating physician. The solution is typically diluted in compatible IV fluids and administered over a controlled period to minimise infusion‑related reactions.

Serious adverse events include cardiac conduction abnormalities such as PR‑interval prolongation, severe skin reactions like Stevens‑Johnson syndrome, suicidal thoughts or behaviours, and anaphylactic reactions. Patients should be monitored for these signs, especially during initiation and dose escalation.

Lacosamide Vivanta is contraindicated in patients with known hypersensitivity to lacosamide or any excipients in the formulation. Caution is advised for individuals with significant cardiac conduction disorders, severe renal impairment, or those taking interacting medications that could markedly alter lacosamide levels.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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