Product image of Lacosamide Zentiva (Lacosamide) supplied by GNH India

Lacosamide Zentiva

Active Ingredient:
Lacosamide
Origin:
EU

Lacosamide Zentiva (Lacosamide)

Lacosamide, the active ingredient in Lacosamide Zentiva, is an anticonvulsant presented as an oral tablet for oral use. It is indicated for adjunctive therapy of partial‑onset seizures in patients with epilepsy, helping to reduce seizure frequency when added to existing antiepileptic regimens and significantly improving overall seizure control.

GNH India supplies Lacosamide Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with a focus on reliable quality, regulatory compliance and on‑time delivery across global markets.

Manufacturer / TM Owner

Zentiva France

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Indications & Clinical Uses

Lacosamide is an anticonvulsant used in the management of epilepsy, specifically targeting focal seizure activity.

  • Partial‑onset seizures: reduces seizure frequency when used as add‑on therapy
  • Focal epilepsy: improves seizure control as adjunctive treatment
  • Adjunctive therapy in epilepsy: complements existing antiepileptic regimens to achieve better seizure management

How It Works

  • Lacosamide enhances the slow inactivation of voltage‑gated sodium channels, stabilizing neuronal membranes and diminishing hyper‑excitability. It also binds to the collapsin response mediator protein‑2 (CRMP‑2), influencing neuronal signaling pathways that contribute to seizure propagation, thereby providing anticonvulsant effects.

Side Effects

Lacosamide may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Dizziness
  • Headache
  • Nausea
  • Fatigue
  • Blurred vision
  • Diplopia

Serious or Rare Side Effects

  • Suicidal ideation or behavior
  • Severe allergic reactions (e.g., angioedema, anaphylaxis)
  • Cardiac arrhythmias, including atrioventricular block
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Hepatotoxicity or elevated liver enzymes
  • Respiratory depression in combination with CNS depressants

Precautions & Warnings

When prescribing Lacosamide, clinicians should consider several safety aspects.

  • Renal impairment: assess kidney function and adjust dosing if necessary
  • Hepatic impairment: monitor liver enzymes regularly
  • Cardiac conduction disorders: avoid use in patients with known PR‑interval prolongation
  • Pregnancy: safety not established; use only if potential benefit outweighs risk
  • Concomitant CNS depressants: monitor for additive sedation or respiratory effects
  • Store at ambient temperature: keep below 25°C, protect from moisture and light

Avoid Interactions

Lacosamide can interact with other medicines, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase lacosamide plasma levels
  • Strong CYP3A4 inducers (e.g., carbamazepine): may reduce lacosamide effectiveness

Moderate Interactions (Monitor Closely)

  • Other antiepileptic drugs (e.g., valproate, phenytoin): may require dose adjustments
  • CNS depressants (e.g., benzodiazepines, alcohol): may enhance sedation
  • QT‑prolonging agents: monitor cardiac rhythm for potential arrhythmias

Frequently Asked Questions

Lacosamide Zentiva is used as an adjunctive therapy for partial‑onset (focal) seizures in patients with epilepsy. It is added to existing antiepileptic regimens to help lower seizure frequency and improve overall seizure control.

Lacosamide works by enhancing the slow inactivation of voltage‑gated sodium channels, which stabilizes neuronal membranes and reduces hyper‑excitability. It also binds to CRMP‑2, a protein involved in neuronal signaling, further contributing to its anticonvulsant effect.

The specific dose of Lacosamide Zentiva is determined by the prescribing clinician based on the patient’s medical condition, response to therapy, and other individual factors. Only a qualified healthcare professional should set the dosing regimen.

The safety of Lacosamide during pregnancy and lactation has not been fully established. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and the decision should be made by a healthcare provider.

To order Lacosamide Zentiva, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lacosamide’s unique mechanism—enhancing slow sodium‑channel inactivation and binding CRMP‑2—differs from many traditional antiepileptics that primarily affect fast sodium channels or GABA pathways. This can offer an alternative for patients who have inadequate response or intolerable side effects with other agents.

Lacosamide Zentiva should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from moisture, excessive heat and direct light to maintain its stability and potency.

Lacosamide Zentiva is taken orally, usually as a tablet, and should be swallowed with water. It is typically taken with or without food, following the dosing schedule prescribed by the treating physician.

Serious risks include the potential for suicidal thoughts or behavior, severe allergic reactions such as anaphylaxis, cardiac conduction abnormalities like atrioventricular block, and rare skin reactions such as Stevens‑Johnson syndrome. Patients should be monitored closely for any of these events.

Lacosamide should be avoided in patients with known hypersensitivity to the drug or its excipients, and in those with significant cardiac conduction disorders (e.g., PR‑interval prolongation) unless the benefits outweigh the risks. Clinicians should also exercise caution in patients with severe renal or hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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