Product image of Lacosamide Zentiva (Lacosamide) supplied by GNH India

Lacosamide Zentiva

Active Ingredient:
Lacosamide
Origin:
EU

Lacosamide Zentiva (Lacosamide)

Lacosamide, the active ingredient in Lacosamide Zentiva, is a sodium channel blocker presented as an oral tablet for oral use. It is used as adjunctive therapy for partial‑onset seizures in patients with epilepsy.
GNH India supplies Lacosamide Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zentiva Pharma Uk Limited

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Indications & Clinical Uses

  • Lacosamide is an anticonvulsant that acts on neuronal sodium channels to control seizure activity.
  • Partial‑onset seizures: used as adjunctive therapy to reduce seizure frequency in patients with epilepsy.

How It Works

  • Lacosamide enhances the slow inactivation of voltage‑gated sodium channels, which stabilizes hyperexcitable neuronal membranes and reduces the likelihood of repetitive firing. By selectively targeting the slow inactivation phase, it modulates neuronal excitability without significantly affecting normal conduction, contributing to its anticonvulsant effect in epilepsy management.

Side Effects

Lacosamide may cause a range of adverse reactions, from mild to serious. Monitoring and reporting are essential for patient safety.

Common Side Effects

  • Dizziness: sensation of light‑headedness or unsteadiness.
  • Nausea: mild to moderate stomach upset.
  • Fatigue: feeling unusually tired or weak.
  • Headache: mild to moderate pain in the head.
  • Tremor: involuntary shaking of limbs.
  • Diplopia: occasional double vision.

Serious or Rare Side Effects

  • Cardiac arrhythmia: irregular heart rhythm, potentially life‑threatening.
  • Severe skin reactions: such as Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Suicidal thoughts: emergence of depressive symptoms or suicidal ideation.
  • Hypersensitivity: anaphylactic reactions including swelling, rash, or breathing difficulty.

Precautions & Warnings

Before initiating Lacosamide therapy, consider the following safety measures.

  • Renal impairment: adjust dosing and monitor renal function.
  • Hepatic impairment: use caution and assess liver enzymes regularly.
  • Cardiac history: evaluate baseline ECG and monitor for PR‑interval changes.
  • Concomitant CNS depressants: assess for additive sedation or dizziness.
  • Pregnancy and lactation: discuss potential risks with a healthcare professional.
  • Store at ambient temperature: keep below 25°C in the original packaging, protect from moisture.

Avoid Interactions

Lacosamide can interact with other medicines, altering its effectiveness or safety profile.

Major Interactions (Avoid)

  • Carbamazepine: may reduce Lacosamide plasma levels.
  • Phenytoin: can decrease Lacosamide exposure.
  • Rifampin: may increase metabolism, lowering efficacy.

Moderate Interactions (Monitor Closely)

  • CYP2C19 inhibitors (e.g., fluoxetine): may increase Lacosamide concentrations.
  • Other sodium channel blockers (e.g., lamotrigine): monitor for additive CNS effects.
  • Anticoagulants (e.g., warfarin): observe for potential changes in coagulation parameters.

Frequently Asked Questions

Lacosamide Zentiva is prescribed as an adjunctive therapy for partial‑onset seizures in patients with epilepsy. It helps reduce the frequency of seizures when used together with other antiepileptic medications, providing additional seizure control for individuals who have not achieved adequate control with monotherapy.

Lacosamide works by enhancing the slow inactivation of voltage‑gated sodium channels in neuronal membranes. This action stabilizes hyperexcitable neurons, decreasing the likelihood of repetitive firing that can lead to seizures. By targeting the slow inactivation phase, it modulates excitability without markedly affecting normal nerve conduction.

The appropriate dose of Lacosamide Zentiva is determined by the prescribing clinician based on the patient’s clinical condition, response, and tolerability. Dosage adjustments may be needed for renal or hepatic impairment, and the prescriber will provide individualized dosing instructions.

Safety data for Lacosamide in pregnancy and lactation are limited. Healthcare providers should weigh the potential benefits against possible risks to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss treatment options with their physician before using Lacosamide.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After submission, the sales team will verify trade or institutional credentials, then respond with pricing, availability, shipping details, and any necessary import documentation.

Lacosamide belongs to the sodium channel blocker class, offering a unique mechanism that enhances slow inactivation of sodium channels. Compared with other anticonvulsants such as carbamazepine or phenytoin, it may have a more favorable interaction profile and a lower risk of certain enzyme‑inducing effects, though individual response varies.

Lacosamide Zentiva tablets should be stored at ambient temperature, below 25 °C, in the original container to protect them from moisture and light. Keep the medication out of reach of children and avoid storing in humid or excessively hot environments.

Lacosamide Zentiva is taken orally, usually as a tablet, with or without food as directed by the prescriber. The tablets should be swallowed whole with water and not crushed or chewed unless specifically instructed by a healthcare professional.

Serious risks include cardiac arrhythmias such as PR‑interval prolongation, severe skin reactions like Stevens‑Johnson syndrome, and rare but critical psychiatric effects including suicidal thoughts. Patients should be monitored regularly for any signs of these conditions, and immediate medical attention is required if they occur.

Lacosamide Zentiva is contraindicated in patients with known hypersensitivity to Lacosamide or any of its excipients. Individuals with significant cardiac conduction abnormalities, uncontrolled severe hepatic or renal impairment, or those taking interacting medications that cannot be safely managed should avoid using this drug unless a specialist advises otherwise.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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