Product image of Lacrat (Ticagrelor) supplied by GNH India

Lacrat

Active Ingredient:
Ticagrelor
Origin:
EU

Lacrat (Ticagrelor)

Ticagrelor, the active ingredient in Lacrat, is a P2Y12 receptor antagonist presented as an oral tablet for oral use. It treats acute coronary syndrome, myocardial infarction, and helps prevent thrombotic cardiovascular events in adult patients.\n\nGNH India supplies Lacrat as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Medochemie Hellas Sa

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Indications & Clinical Uses

  • Lacrat (ticagrelor) acts on platelet aggregation pathways to reduce thrombotic risk in cardiovascular disease.\n\nAcute coronary syndrome: lowers the incidence of cardiovascular death, myocardial infarction and stroke.\nMyocardial infarction: prevents recurrent ischemic events after an acute event.\nPrevention of thrombotic cardiovascular events: reduces clot formation in patients at high risk of arterial thrombosis.

How It Works

  • Ticagrelor is a reversible antagonist of the platelet P2Y12 ADP receptor. By binding to this receptor it blocks ADP‑mediated activation of the GPIIb/IIIa complex, thereby inhibiting platelet aggregation and thrombus formation without requiring metabolic activation.

Side Effects

  • Adverse reactions may range from mild to severe and should be monitored during therapy.\n\nCommon Side Effects:\n- Dyspnea: shortness of breath, often transient.\n- Headache: mild to moderate intensity.\n- Nausea: occasional gastrointestinal upset.\n- Bleeding: minor bruising or gum bleeding.\n- Dizziness: light‑headed sensations.\n- Diarrhea: loose stools in some patients.\n\nSerious or Rare Side Effects:\n- Severe bleeding: intracranial or gastrointestinal hemorrhage.\n- Hypersensitivity reactions: rash, angioedema, anaphylaxis.\n- Hepatic injury: elevated liver enzymes or hepatitis.\n- Thrombocytopenia: marked reduction in platelet count.

Precautions & Warnings

  • Before initiating Lacrat, clinicians should evaluate patient‑specific risk factors and monitor therapy.\n\nAssess bleeding risk: review history of hemorrhage or anticoagulant use.\nMonitor liver function: periodic tests for hepatic safety.\nAdjust dose in renal impairment: consider reduced dosing for severe renal dysfunction.\nAvoid use in active pathological bleeding: contraindicated in ongoing hemorrhage.\nReview concomitant anticoagulants: increased bleeding potential with warfarin or DOACs.\nStore at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

  • Ticagrelor may interact with several drug classes, requiring careful management.\n\nMajor Interactions (Avoid):\n- Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may increase ticagrelor exposure.\n- Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce efficacy.\n- Anticoagulants (e.g., warfarin, direct oral anticoagulants): heightened bleeding risk.\n- Non‑steroidal anti‑inflammatory drugs (NSAIDs): additive bleeding potential.\n\nModerate Interactions (Monitor Closely):\n- Moderate CYP3A4 inhibitors (e.g., diltiazem, verapamil): may modestly raise levels.\n- Moderate CYP3A4 inducers (e.g., phenytoin, phenobarbital): may modestly lower levels.\n- Selective serotonin reuptake inhibitors (SSRIs) or SNRIs: increased bleeding tendency.

Frequently Asked Questions

Lacrat contains ticagrelor, an antiplatelet medication indicated for the treatment of acute coronary syndrome, for patients who have experienced a myocardial infarction, and for the prevention of thrombotic cardiovascular events in adults at high risk of clot formation.

Ticagrelor reversibly blocks the platelet P2Y12 ADP receptor, preventing ADP‑mediated activation of the GPIIb/IIIa complex. This inhibition stops platelets from aggregating, thereby reducing the formation of arterial clots that can lead to heart attacks or strokes.

The dosage of Lacrat is determined by the prescribing clinician based on the patient’s clinical condition, renal function, and concomitant therapies. The prescriber will select the appropriate strength and dosing schedule according to approved guidelines.

Safety data for ticagrelor in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To request Lacrat, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

The primary alternative to ticagrelor is clopidogrel, another P2Y12 inhibitor. Ticagrelor provides more rapid and consistent platelet inhibition without needing metabolic activation, which can result in a quicker onset of action and potentially greater efficacy in acute coronary settings.

Lacrat tablets should be stored at ambient temperature, below 25 °C, in the original container to protect them from moisture and light. Keep the product out of reach of children and avoid storing in humid or excessively hot environments.

Lacrat is taken orally as a tablet. Patients should swallow the tablet whole with water and follow the dosing schedule prescribed by their healthcare provider. It is usually taken with or without food, as directed.

The most serious risks include severe or uncontrolled bleeding, hypersensitivity reactions such as rash or anaphylaxis, and rare hepatic injury. Patients should seek immediate medical attention if they experience signs of major bleeding, severe rash, or jaundice.

Lacrat is contraindicated in patients with active pathological bleeding, a history of intracranial hemorrhage, severe hepatic impairment, or known hypersensitivity to ticagrelor or any of the tablet’s excipients. Clinicians should assess each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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