P-Tabletten Weiß 10 Mm Lichtenstein (Lactose Monohydrate)

Lactose Monohydrate is an excipient used in oral solid dosage forms and contributes to the manufacturing and stability of various pharmaceutical products.

• Tablet formulation: Provides bulk and improves tablet compressibility.
• Capsule filling: Acts as a carrier for active ingredients.
• Liquid suspensions: Enhances uniformity and flow properties.
• Powder blends: Facilitates accurate dosing in compounding.
• Lyophilized products: Serves as a cryoprotectant during freeze‑drying.

• Lactose monohydrate functions as an inert carrier that integrates into the solid matrix of a tablet or capsule. It dissolves readily in gastrointestinal fluids, creating a solution that releases the active pharmaceutical ingredient without interacting with biological targets, thereby supporting drug delivery and stability.

Lactose monohydrate is generally well tolerated, but adverse reactions can occur, particularly in individuals with lactose intolerance or hypersensitivity.

Common Side Effects

• Gastrointestinal discomfort: Bloating, flatulence, or mild abdominal cramping.
• Diarrhea: Loose stools occurring after ingestion of larger amounts.
• Nausea: Mild queasiness without vomiting.
• Skin rash: Localized erythema or itching at the site of contact.

Serious or Rare Side Effects

• Anaphylactic reaction: Rapid onset of hives, swelling, and breathing difficulty.
• Severe abdominal pain: Persistent or worsening pain requiring medical evaluation.
• Hypotension: Unexplained drop in blood pressure following ingestion.
• Angio‑edema: Swelling of lips, tongue, or face.

When using lactose monohydrate tablets, consider the following safety measures:

• Assess intolerance: Verify patient history for lactose intolerance before administration.
• Monitor reactions: Observe for any signs of allergic response during initial dosing.
• Adjust formulation: Use alternative excipients for patients with known severe lactose sensitivity.
• Pediatric use: Apply caution in children, adjusting dosage forms as appropriate.
• Drug compatibility: Ensure no incompatibility with co‑administered medications that may affect dissolution.
• Store at ambient temperature: Keep below 25°C in the original packaging, protected from moisture.

Lactose monohydrate may interact indirectly with certain medications or formulations.

Major Interactions (Avoid)

• Antibiotics (tetracycline class): May bind to lactose, reducing absorption of the antibiotic.
• Iron supplements: Can form complexes that diminish iron bioavailability.

Moderate Interactions (Monitor Closely)

• Levothyroxine: Potentially altered dissolution rate affecting thyroid hormone levels.
• Proton pump inhibitors: May change gastric pH, influencing lactose dissolution.
• Oral contraceptives: Slight variation in absorption kinetics reported in some studies.
• Antifungal azoles: Possible reduced solubility when co‑administered in the same dosage form.