P-Tabletten Weiß 8 Mm Lichtenstein (Lactose Monohydrate)

Lactose Monohydrate is an excipient used in oral solid dosage forms and supports manufacturing and patient administration:

• Tablet formulation: Provides bulk and improves tablet compressibility.
• Capsule filling: Acts as a carrier for active pharmaceutical ingredients.
• Liquid suspensions: Enhances stability and palatability when used as a dry powder base.
• Pediatric formulations: Allows dose flexibility and taste masking.
• Clinical trial supplies: Serves as an inert filler.
• Over‑the‑counter supplements: Used as a carrier in vitamin and mineral tablets.

• Lactose monohydrate functions as an inert carrier and filler in solid dosage forms. It dissolves readily in gastrointestinal fluids, releasing the active pharmaceutical ingredient without interacting with biological targets. Its crystalline structure provides consistent flow properties and compressibility, facilitating uniform tablet weight and dose accuracy.

Lactose monohydrate is generally well tolerated, but some individuals may experience reactions, particularly if they have a lactose intolerance or allergy.

Common Side Effects

• Gastrointestinal discomfort: Mild bloating or gas.
• Nausea: Transient feeling of nausea.
• Diarrhea: Loose stools in sensitive individuals.
• Abdominal cramping: Mild cramping after ingestion.

Serious or Rare Side Effects

• Anaphylaxis: Severe allergic reaction, rare.
• Angio‑Angulation: Swelling of face, lips, or throat.
• Severe abdominal pain: Persistent, intense pain.
• Hypersensitivity rash: Widespread rash or hives.

When using lactose monohydrate‑containing products, consider the following precautions:

• Assess intolerance: Verify patient history of lactose intolerance before use.
• Monitor reactions: Observe for any signs of hypersensitivity during initial administration.
• Adjust formulation: Use alternative excipients for patients with confirmed lactose allergy.
• Pediatric use: Ensure appropriate dosing form for children to avoid excessive lactose intake.
• Storage: Store below 25°C: keep in the original pack, protect from moisture.

Lactose monohydrate is pharmacologically inactive, but its presence can influence the performance of other drugs in a formulation.

Major Interactions (Avoid)

• Antibiotic stability: Certain antibiotics may degrade faster in the presence of lactose.
• Probiotic viability: Lactose can affect the survival of some probiotic strains.

Moderate Interactions (Monitor Closely)

• Iron absorption: Lactose may modestly reduce iron bioavailability.
• Calcium supplements: May alter calcium salt solubility.
• Thyroid medication: Potential minor impact on levothyroxine absorption.