Product image of Lactulade (Lactulose) supplied by GNH India

Lactulade

Active Ingredient:
Lactulose
Origin:
EU

Lactulade (Lactulose)

Lactulose, the active ingredient in Lactulade, is an osmotic laxative presented as an oral solution for oral use. It treats constipation and hepatic encephalopathy in adults, helping to regulate bowel movements and reduce blood ammonia levels.

GNH India supplies Lactulade as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Cnp Pharma Gmbh

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Indications & Clinical Uses

Lactulose is used to manage conditions related to bowel motility and ammonia metabolism.

  • Constipation: relieves chronic constipation by increasing stool water content and promoting bowel movements.
  • Hepatic encephalopathy: lowers blood ammonia, improving neurological function in patients with liver disease.
  • Colonic cleansing: provides bowel evacuation prior to certain diagnostic or therapeutic procedures.

How It Works

  • Lactulose is a synthetic disaccharide that is not absorbed in the small intestine. In the colon, bacterial enzymes hydrolyze it to short‑chain fatty acids, increasing osmotic pressure and drawing water into the lumen. The resulting acidification converts ammonia (NH3) to non‑absorbable ammonium (NH4+), facilitating its excretion and stimulating peristalsis.

Side Effects

Lactulose may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Abdominal bloating
  • Flatulence
  • Diarrhea
  • Nausea
  • Abdominal cramps
  • Increased thirst

Serious or Rare Side Effects

  • Severe electrolyte imbalance (e.g., hyponatremia)
  • Marked dehydration
  • Allergic reactions (rash, urticaria, angioedema)
  • Severe abdominal pain or colonic perforation

Precautions & Warnings

Before initiating lactulose therapy, consider the following safety measures.

  • Renal function assessment: evaluate kidney status, especially in patients with chronic kidney disease.
  • Electrolyte monitoring: check serum electrolytes during prolonged use.
  • Diabetes caution: monitor blood glucose as lactulose contains carbohydrate calories.
  • Intestinal obstruction: avoid use in patients with known mechanical blockage.
  • Elderly dosage: start with lower doses and titrate cautiously.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Lactulose can interact with other medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Antacids containing magnesium: may decrease lactulose effectiveness.
  • Loop diuretics: increased risk of electrolyte disturbances.
  • Insulin or oral hypoglycemics: carbohydrate content may alter glucose control.

Moderate Interactions (Monitor Closely)

  • Antibiotics (e.g., rifaximin): may affect gut flora and lactulose metabolism.
  • Probiotics: potential alteration of bacterial hydrolysis of lactulose.
  • Oral potassium supplements: monitor serum potassium levels.

Frequently Asked Questions

Lactulade contains lactulose, an osmotic laxative used primarily to treat chronic constipation and to lower blood ammonia levels in patients with hepatic encephalopathy, helping improve bowel regularity and neurological function.

Lactulose reaches the colon unchanged, where bacterial enzymes break it down into short‑chain fatty acids. This increases osmotic pressure, draws water into the intestinal lumen, softens stools, and acidifies the colon, converting ammonia to non‑absorbable ammonium for excretion.

The appropriate dose of Lactulade is determined by the prescribing healthcare professional based on the individual’s condition, response, and tolerance. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for lactulose in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the Lactulade product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies institutional credentials, and then provides pricing, availability, shipping details and required import documentation.

Lactulade (lactulose) is an osmotic laxative that works by increasing colonic water content, unlike stimulant laxatives that act on intestinal nerves. It also has the unique ability to lower ammonia levels, a benefit not shared by most other laxatives.

Lactulade should be stored at room temperature, below 25 °C, in its original packaging. Protect the product from moisture and direct sunlight to maintain stability and potency.

Lactulade is taken orally, usually as a liquid solution. It can be measured with a calibrated dose spoon or cup and swallowed directly or mixed with a small amount of water, as directed by the prescriber.

Serious risks include severe electrolyte imbalance, marked dehydration, allergic reactions such as rash or angioedema, and, rarely, colonic perforation. Patients should seek immediate medical attention if they experience severe abdominal pain, persistent diarrhea, or signs of an allergic response.

Lactulade is contraindicated in individuals with known hypersensitivity to lactulose, those with intestinal obstruction, or severe renal impairment where fluid balance cannot be monitored. It should also be used with caution in patients with diabetes or electrolyte disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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