Product image of Lactulose 1 A Pharma (Lactulose) supplied by GNH India

Lactulose 1 A Pharma

Active Ingredient:
Lactulose
Origin:
EU

Lactulose 1 A Pharma (Lactulose)

Lactulose, the active ingredient in Lactulose 1 A Pharma, is an osmotic laxative presented as an oral formulation for oral use. It treats constipation and helps manage hepatic encephalopathy in patients with liver disease.

GNH India supplies Lactulose 1 A Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

1 A Pharma Gmbh

1
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Indications & Clinical Uses

  • Lactulose is an osmotic laxative used to treat conditions related to bowel motility and ammonia accumulation.
  • Constipation: softens stools and promotes bowel movements, relieving chronic constipation.
  • Hepatic encephalopathy: reduces intestinal ammonia absorption, helping to control episodes of hepatic encephalopathy.

How It Works

  • Lactulose is a synthetic disaccharide that is not absorbed in the small intestine. In the colon it is metabolized by bacterial flora into short‑chain fatty acids, which increase the osmotic pressure within the lumen, drawing water into the bowel and softening the stool. The resulting acidification of colonic contents also traps ammonia as ammonium, decreasing its absorption and lowering systemic ammonia levels.

Side Effects

Lactulose may cause a range of adverse reactions, most of which are related to its laxative action.

Common Side Effects

  • Abdominal cramping
  • Flatulence
  • Diarrhea
  • Nausea

Serious or Rare Side Effects

  • Severe dehydration
  • Electrolyte imbalance (e.g., low potassium)
  • Allergic reaction such as rash, itching or swelling

Precautions & Warnings

  • When using lactulose, certain precautions should be observed to ensure safe therapy.
  • Assess renal function: adjust use in patients with renal impairment.
  • Monitor fluid balance: avoid excessive diarrhea that may lead to dehydration.
  • Use cautiously in patients with diabetes: monitor blood glucose as carbohydrate load may affect control.
  • Avoid in patients with known hypersensitivity to lactulose.
  • Pregnancy and lactation: evaluate risk versus benefit before prescribing.
  • Store at room temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Lactulose can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Antibiotics such as rifaximin: may reduce lactulose’s effectiveness by altering gut flora.
  • Other laxatives (e.g., senna, bisacodyl): combined use can cause severe diarrhea and electrolyte loss.

Moderate Interactions (Monitor Closely)

  • Antidiabetic agents: altered carbohydrate absorption may affect glucose control.
  • Mineral supplements (calcium, magnesium): may bind lactulose and diminish its action.
  • Diuretics: increased risk of electrolyte disturbances when used together.

Frequently Asked Questions

Lactulose 1 A Pharma is an oral osmotic laxative indicated for the treatment of chronic constipation and for the management of hepatic encephalopathy in patients with liver disease. In constipation it softens stools and promotes regular bowel movements, while in hepatic encephalopathy it lowers blood ammonia levels by acidifying the colon, thereby helping to prevent or control neuropsychiatric episodes.

Lactulose is a synthetic sugar that reaches the colon unchanged, where intestinal bacteria ferment it into short‑chain fatty acids. These acids increase the osmotic pressure inside the bowel, drawing water into the lumen and softening the stool. The resulting acidic environment also converts ammonia to ammonium, which is poorly absorbed, thus reducing systemic ammonia levels.

The dose of lactulose is individualized. A qualified prescriber determines the amount, frequency, and duration based on the specific condition being treated, the patient’s response, and any relevant clinical factors. Patients should follow the prescribing information provided by their healthcare professional.

Data on lactulose use during pregnancy and lactation are limited. It should only be used when the potential benefit justifies any possible risk to the fetus or infant. Healthcare providers will assess the individual situation and decide whether lactulose is appropriate for a pregnant or nursing patient.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After the request, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details (including any cold‑chain requirements if applicable), and the necessary import documentation.

Lactulose belongs to the osmotic laxative class, acting by increasing water content in the colon. Compared with stimulant laxatives (e.g., senna) it generally produces softer stools with less cramping. Polyethylene glycol (PEG) is another osmotic agent; lactulose also offers the added benefit of reducing ammonia absorption, making it useful for hepatic encephalopathy, a property PEG does not provide.

Lactulose should be stored at room temperature, below 25 °C, in its original container. Keep the product away from moisture, direct sunlight, and excessive heat. Ensure the seal remains intact until use, and keep it out of reach of children.

Lactulose is taken orally, usually dissolved in a glass of water or another suitable liquid. It may be consumed with or without food, as directed by the prescribing clinician. Patients should drink an adequate amount of fluid throughout the day to help prevent dehydration.

The most serious risks include severe dehydration, electrolyte disturbances such as low potassium or sodium, and rare allergic reactions that may present as rash, itching, swelling, or difficulty breathing. If any of these symptoms occur, medical attention should be sought promptly.

Lactulose should be avoided in individuals with known hypersensitivity to the product, those with intestinal obstruction, severe renal impairment, or active gastrointestinal bleeding. Patients with these conditions should consult their healthcare provider for alternative therapies.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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