Product image of Lactulose Aurobindo (Lactulose) supplied by GNH India

Lactulose Aurobindo

Active Ingredient:
Lactulose
Origin:
EU

Lactulose Aurobindo (Lactulose)

Lactulose, the active ingredient in Lactulose Aurobindo, is an osmotic laxative presented as an oral formulation for oral use. It treats constipation and hepatic encephalopathy in appropriate patients.

GNH India supplies Lactulose Aurobindo as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aurobindo Pharma B.V.

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Indications & Clinical Uses

Lactulose acts on the gastrointestinal tract to relieve bowel stasis and to lower ammonia absorption in liver disease.

  • Constipation: promotes regular bowel movements by drawing water into the intestinal lumen.
  • Hepatic encephalopathy: reduces blood ammonia levels, helping to improve mental status in patients with liver dysfunction.

How It Works

  • Lactulose is a synthetic disaccharide that reaches the colon unchanged, where bacterial enzymes hydrolyze it to short‑chain fatty acids. The resulting acidification lowers colonic pH, creating an osmotic gradient that draws water into the lumen and softens stool. Simultaneously, ammonia is trapped as ammonium ions, decreasing its systemic absorption and aiding patients with hepatic encephalopathy.

Side Effects

Lactulose may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Abdominal cramping: discomfort due to increased intestinal activity.
  • Flatulence: excess gas production from bacterial fermentation.
  • Diarrhea: loose stools from osmotic water influx.
  • Nausea: mild upset stomach.
  • Bloating: sensation of fullness.

Serious or Rare Side Effects

  • Electrolyte imbalance: significant loss of potassium or sodium.
  • Severe dehydration: excessive fluid loss leading to hypotension.
  • Allergic reaction: rash, itching, or swelling requiring medical attention.

Precautions & Warnings

Before initiating Lactulose therapy, consider the following safety measures.

  • Renal function assessment: monitor kidney status in patients with impaired renal clearance.
  • Electrolyte monitoring: check serum potassium and sodium during prolonged use.
  • Caution in hepatic impairment: adjust dose if liver function is severely compromised.
  • Avoid in intestinal obstruction: risk of worsening blockage.
  • Diabetes monitoring: observe blood glucose as lactulose may affect glycemic control.
  • Store below 25°C: keep in the original pack, protect from moisture and heat.

Avoid Interactions

Lactulose can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Magnesium‑containing antacids: may increase osmotic load and cause severe diarrhea.
  • Other laxatives: combined use can lead to excessive fluid loss.
  • Antibiotics that disrupt gut flora: may reduce lactulose metabolism and effectiveness.

Moderate Interactions (Monitor Closely)

  • Oral hypoglycemics: possible alteration of glucose levels.
  • Diuretics: increased risk of electrolyte disturbances.
  • Probiotics: may modify bacterial fermentation of lactulose.
  • Sodium‑containing medications: monitor overall sodium balance.

Frequently Asked Questions

Lactulose Aurobindo is used to relieve constipation and to manage hepatic encephalopathy. In constipation, it softens stool and promotes regular bowel movements. In hepatic encephalopathy, it lowers blood ammonia levels, helping to improve neurological symptoms in patients with liver disease.

Lactulose is a synthetic sugar that reaches the colon unchanged. Gut bacteria ferment it into short‑chain fatty acids, which lower colonic pH and create an osmotic gradient that draws water into the lumen, softening stool. The acidic environment also converts ammonia to ammonium, reducing its absorption into the bloodstream.

The specific dose of Lactulose Aurobindo is determined by the prescribing healthcare professional based on the patient’s condition, age, renal and hepatic function, and response to therapy. Dosage instructions are provided on the prescription label and should be followed exactly as directed.

Safety data for Lactulose in pregnancy and lactation are limited. It is generally classified as a Category C medication, meaning risk cannot be ruled out. Healthcare providers should weigh the potential benefits against possible risks before prescribing it to pregnant or nursing mothers.

To order Lactulose Aurobindo, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.

Lactulose is an osmotic laxative that works by drawing water into the colon, whereas stimulant laxatives such as bisacodyl increase intestinal motility. Compared with bulk‑forming agents like psyllium, lactulose provides a quicker onset of softening stool but may cause more gas and bloating. Choice depends on patient needs and tolerance.

Lactulose Aurobindo should be stored below 25°C in its original packaging, protected from moisture and direct heat. Keeping the product in a cool, dry place helps maintain its stability and effectiveness throughout its shelf life.

Lactulose Aurobindo is taken orally, usually as a liquid solution. It can be measured with a calibrated dose spoon or cup and taken with or without food, according to the prescribing clinician’s instructions.

The most serious risks include severe dehydration, electrolyte imbalances (especially low potassium), and rare allergic reactions. Patients should be monitored for signs of excessive fluid loss, muscle weakness, or any hypersensitivity symptoms and seek medical attention promptly if they occur.

Lactulose Aurobindo should be avoided in patients with known hypersensitivity to lactulose, those with intestinal obstruction, or severe hepatic failure where ammonia production cannot be adequately managed. It should also be used with caution in individuals with renal impairment or uncontrolled diabetes.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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