Product image of Lactulose Eg (Lactulose) supplied by GNH India

Lactulose Eg

Active Ingredient:
Lactulose
Origin:
EU

Lactulose Eg (Lactulose)

Lactulose, the active ingredient in Lactulose Eg, is an osmotic laxative presented as an oral solution for oral administration. It works by drawing water into the intestinal lumen, thereby softening stools and reducing ammonia absorption, and is indicated for the treatment of constipation and the management of hepatic encephalopathy in adult patients.

GNH India supplies Lactulose Eg as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable sourcing for global healthcare markets.

Manufacturer / TM Owner

Eurogenerics N.V./S.A.

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Indications & Clinical Uses

Lactulose is an osmotic laxative that acts on the gastrointestinal tract to relieve constipation and lower ammonia levels in liver disease.

  • Constipation: softens stool and promotes regular bowel movements.
  • Hepatic encephalopathy: reduces intestinal ammonia absorption, helping to improve neurological symptoms.

How It Works

  • Lactulose is a synthetic disaccharide that is not absorbed in the small intestine. In the colon, bacterial enzymes hydrolyze it to short‑chain fatty acids, which increase the osmotic pressure within the lumen, drawing water into the bowel and stimulating peristalsis. The acidic environment also converts ammonia (NH₃) to ammonium (NH₄⁺), which is trapped and eliminated, thereby lowering systemic ammonia levels.

Side Effects

Lactulose may cause a range of adverse reactions, most of which are related to its osmotic activity in the gut.

Common Side Effects

  • Abdominal bloating
  • Flatulence
  • Diarrhea
  • Nausea
  • Abdominal cramps
  • Increased thirst

Serious or Rare Side Effects

  • Severe electrolyte imbalance (e.g., hyponatremia, hypokalemia)
  • Dehydration
  • Allergic reactions such as rash or urticaria
  • Severe abdominal pain
  • Hypovolemia
  • Rare cases of colonic perforation

Precautions & Warnings

When prescribing Lactulose, clinicians should consider several safety precautions to minimize risks.

  • Dose adjustment: Reduce dose in patients with renal impairment or severe liver disease.
  • Electrolyte monitoring: Check serum electrolytes regularly during prolonged therapy.
  • Diabetes caution: Monitor blood glucose as Lactulose may affect carbohydrate metabolism.
  • Obstruction warning: Avoid use in patients with known intestinal obstruction or perforation.
  • Fluid balance: Ensure adequate hydration to prevent dehydration.
  • Store at ambient temperature: Keep below 25 °C in the original container, protected from moisture and light.

Avoid Interactions

Lactulose can interact with other medicines, influencing efficacy or safety.

Major Interactions (Avoid)

  • Concomitant use with strong laxatives (e.g., senna, bisacodyl) may cause severe diarrhea and electrolyte loss.
  • Co‑administration with diuretics can exacerbate dehydration and electrolyte disturbances.

Moderate Interactions (Monitor Closely)

  • Antibiotics that alter gut flora (e.g., rifaximin) may modify Lactulose’s effect on ammonia production.
  • Probiotic supplements may reduce the osmotic effect of Lactulose.
  • Antacids containing magnesium may increase gastrointestinal side effects.
  • Antidiarrheal agents (e.g., loperamide) may diminish Lactulose’s intended laxative action.

Frequently Asked Questions

Lactulose Eg is used as an osmotic laxative to treat constipation and to manage hepatic encephalopathy in adults. In constipation, it softens stools and promotes bowel movements. In hepatic encephalopathy, it helps lower blood ammonia levels, which can improve neurological symptoms associated with liver disease.

Lactulose is a synthetic sugar that reaches the colon unchanged. Colonic bacteria break it down into short‑chain fatty acids, which increase the osmotic pressure in the intestinal lumen. This draws water into the bowel, softening stool and stimulating peristalsis. The resulting acidic environment also converts ammonia to ammonium, trapping it for excretion and reducing systemic ammonia levels.

The appropriate dose of Lactulose Eg is individualized by the prescribing healthcare professional based on the patient’s condition, severity of symptoms, age, renal and hepatic function, and response to therapy. Dosage may be adjusted over time to achieve the desired clinical effect while minimizing side effects.

Safety data for Lactulose in pregnancy and lactation are limited. It is generally categorized as a drug to be used only if the potential benefit justifies the potential risk to the fetus or infant. Healthcare providers should evaluate the risk‑benefit profile for each patient and discuss alternatives when appropriate.

To order Lactulose Eg, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After the request, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details (including any temperature requirements) and assist with import documentation.

Lactulose belongs to the osmotic laxative class, differing from stimulant laxatives (e.g., bisacodyl) that increase intestinal motility, and bulk‑forming agents (e.g., psyllium) that add fiber. Osmotic agents like Lactulose draw water into the colon, providing a gentler, stool‑softening effect and, uniquely, the ability to lower ammonia levels, making it useful for hepatic encephalopathy—a benefit not shared by most other laxatives.

Lactulose should be stored at ambient temperature, preferably below 25 °C, in its original container. The container should be kept tightly closed, protected from moisture and direct sunlight. No special refrigeration is required for the oral solution form, but it should be kept out of reach of children.

Lactulose is administered orally, typically as a liquid solution that can be taken directly or mixed with water or another suitable beverage. The exact volume and frequency are determined by the prescribing clinician, who will tailor the regimen to achieve the desired therapeutic effect while monitoring tolerance.

Serious risks include severe electrolyte disturbances (such as hyponatremia or hypokalemia), dehydration, and rare allergic reactions that may present as rash, urticaria, or anaphylaxis. In extreme cases, excessive fluid loss can lead to hypovolemia or, very rarely, colonic perforation, especially in patients with pre‑existing intestinal obstruction.

Lactulose should be avoided in individuals with known intestinal obstruction, perforated bowel, or severe inflammatory bowel disease. Patients with hypersensitivity to Lactulose or any of its excipients should not use the product. Caution is also advised for those with severe renal impairment or uncontrolled diabetes, and use should be guided by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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