Product image of Lactulose Farmoz (Lactulose) supplied by GNH India

Lactulose Farmoz

Active Ingredient:
Lactulose
Origin:
EU

Lactulose Farmoz (Lactulose)

Lactulose, the active ingredient in Lactulose Farmoz, is an osmotic laxative presented as an oral solution for oral use. It is used to treat constipation and to reduce intestinal ammonia absorption in patients with hepatic encephalopathy.
GNH India supplies Lactulose Farmoz as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Farmoz - Sociedade Técnico Medicinal, S.A.

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Indications & Clinical Uses

Lactulose is an osmotic laxative that acts on the gastrointestinal tract to relieve constipation and lower ammonia levels in liver‑related conditions.

  • Constipation: softens stool and promotes bowel movements.
  • Hepatic encephalopathy: lowers intestinal ammonia to improve neurological symptoms.
  • Hyperammonemia: helps reduce elevated blood ammonia concentrations.

How It Works

  • Lactulose is a synthetic disaccharide that is not absorbed in the small intestine. In the colon it is metabolised by bacterial enzymes into acidic compounds, which increase the osmotic pressure within the lumen, drawing water into the bowel to stimulate laxation and trapping ammonia as ammonium ions, thereby reducing systemic absorption.

Side Effects

Lactulose may cause a range of adverse reactions, most of which are related to its laxative action.

Common Side Effects

  • Abdominal cramping: discomfort due to increased bowel activity.
  • Flatulence: excess gas production from bacterial fermentation.
  • Diarrhoea: loose stools from osmotic effect.
  • Nausea: mild stomach upset.
  • Bloating: sensation of fullness.
  • Thirst: increased fluid loss.

Serious or Rare Side Effects

  • Electrolyte imbalance: especially low potassium levels.
  • Severe dehydration: from excessive fluid loss.
  • Allergic reaction: rash, itching, or swelling.
  • Hypotension: due to fluid shifts.
  • Worsening hepatic encephalopathy: rare paradoxical effect.

Precautions & Warnings

Before prescribing Lactulose, clinicians should consider several safety aspects.

  • Dose adjustment in renal impairment: monitor renal function and adjust as needed.
  • Monitor electrolytes: especially potassium and sodium during prolonged use.
  • Avoid in galactosemia: patients with this metabolic disorder should not receive lactulose.
  • Caution in diabetes: sugar content may affect glycaemic control.
  • Pregnancy and lactation: consult a physician before use.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Lactulose can interact with other medications, requiring attention to avoid reduced efficacy or increased risk.

Major Interactions (Avoid)

  • Concurrent use with other strong laxatives: may cause severe diarrhoea and electrolyte loss.
  • Combination with diuretics: increased risk of dehydration and electrolyte disturbances.

Moderate Interactions (Monitor Closely)

  • Antacids: may alter gut pH and affect lactulose metabolism.
  • Probiotics: could modify bacterial fermentation and efficacy.
  • Oral hypoglycaemic agents: monitor blood glucose due to lactulose's sugar content.

Frequently Asked Questions

Lactulose Farmoz is used as an osmotic laxative to relieve constipation and to lower intestinal ammonia levels in patients with hepatic encephalopathy, helping to improve neurological symptoms associated with liver disease.

Lactulose is a synthetic sugar that reaches the colon unchanged, where gut bacteria break it down into acidic metabolites. These acids increase the osmotic pressure in the intestinal lumen, drawing water into the bowel to soften stool and also converting ammonia to ammonium, which is less readily absorbed.

The appropriate dose of Lactulose Farmoz is determined by the prescribing clinician based on the individual patient's condition, severity of symptoms, and response to therapy. Dosage may be adjusted over time to achieve the desired clinical effect.

Safety of Lactulose Farmoz in pregnancy or while breastfeeding has not been definitively established. Healthcare providers should weigh the potential benefits against any possible risks and discuss these considerations with the patient before initiating therapy.

To order Lactulose Farmoz, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lactulose is an osmotic laxative that works by increasing water content in the colon, whereas stimulant laxatives such as bisacodyl act by stimulating intestinal motility. Lactulose also has the unique benefit of reducing ammonia absorption, making it useful in hepatic encephalopathy, a property not shared by most other laxatives.

Lactulose Farmoz should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the container tightly closed and out of reach of children.

Lactulose Farmoz is taken orally, usually as a liquid solution. It can be measured with a calibrated dosing device and swallowed directly or mixed with a small amount of water or juice to improve palatability, as directed by the prescribing clinician.

Serious risks include severe dehydration, electrolyte disturbances such as hypokalaemia, and rare allergic reactions. Patients should be monitored for signs of excessive fluid loss, weakness, or any hypersensitivity symptoms, and medical attention should be sought promptly if they occur.

Lactulose Farmoz should be avoided in patients with known galactosemia, severe fructose intolerance, or those who have experienced allergic reactions to lactulose. Caution is also advised for individuals with uncontrolled diabetes or significant renal impairment, and use should be guided by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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