Product image of Lactulose Fresenius (Lactulose, Liquid) supplied by GNH India

Lactulose Fresenius

Active Ingredient:
Lactulose, Liquid
Origin:
EU

Lactulose Fresenius (Lactulose, Liquid)

Lactulose, the active ingredient in Lactulose Fresenius, is a osmotic laxative presented as a liquid for oral use. It treats constipation and hepatic encephalopathy in adults by increasing water content in the colon and reducing intestinal ammonia absorption.

GNH India supplies Lactulose Fresenius as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Fresenius Kabi Austria Gmbh

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Indications & Clinical Uses

Lactulose Fresenius is an osmotic laxative used to manage conditions related to bowel motility and ammonia accumulation.

  • Constipation: relieves constipation by softening stools and promoting regular bowel movements.
  • Hepatic encephalopathy: lowers intestinal ammonia absorption, helping improve mental status in patients with liver disease.

How It Works

  • Lactulose is a synthetic disaccharide that is not absorbed in the small intestine. In the colon it is metabolized by bacterial flora into short‑chain fatty acids, which increase the osmotic pressure and draw water into the lumen, softening stool. The acidic environment also converts ammonia to ammonium, reducing its absorption into the bloodstream.

Side Effects

Lactulose may cause a range of adverse reactions, most of which are related to its osmotic activity in the gut.

Common Side Effects

  • Bloating: sensation of abdominal fullness.
  • Flatulence: increased intestinal gas.
  • Abdominal cramps: mild to moderate discomfort.
  • Diarrhea: loose stools, especially at higher doses.
  • Nausea: feeling of sickness.

Serious or Rare Side Effects

  • Severe electrolyte imbalance: may lead to hyponatremia or hypokalemia.
  • Dehydration: excessive fluid loss from diarrhea.
  • Allergic reaction: rash, itching, or swelling.
  • Severe abdominal pain: persistent or worsening pain requiring medical attention.

Precautions & Warnings

When prescribing Lactulose Fresenius, consider patient‑specific factors and handling requirements.

  • Dose adjustment: required in patients with renal impairment.
  • Monitor electrolytes: especially sodium and potassium during prolonged therapy.
  • Avoid abrupt discontinuation: may cause rebound constipation.
  • Use with caution in diabetes: monitor blood glucose as lactulose can affect sugar levels.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Lactulose can interact with other medicines, influencing efficacy or safety.

Major Interactions (Avoid)

  • Antidiarrheal agents (e.g., loperamide): may reduce lactulose's laxative effect.
  • Proton pump inhibitors: may increase risk of bacterial overgrowth, potentially altering lactulose's action.

Moderate Interactions (Monitor Closely)

  • Antibiotics: may change gut flora and affect ammonia reduction.
  • Diabetes medications: lactulose may influence glucose control.
  • Mineral supplements: concurrent use can increase osmotic load and gastrointestinal discomfort.

Frequently Asked Questions

Lactulose Fresenius is prescribed to relieve constipation and to treat hepatic encephalopathy, a condition caused by excess ammonia in patients with severe liver disease. It works by drawing water into the colon and reducing ammonia absorption, helping restore normal bowel function and mental status.

Lactulose is a synthetic sugar that reaches the colon unchanged, where intestinal bacteria ferment it into short‑chain fatty acids. This fermentation creates an osmotic gradient that pulls water into the bowel, softening stool. The resulting acidic environment also converts ammonia to non‑absorbable ammonium, lowering blood ammonia levels.

The dose of Lactulose Fresenius is individualized by the prescribing clinician based on the patient’s condition, severity, and response. The prescriber determines the appropriate volume and frequency, which may be adjusted during treatment to achieve the desired therapeutic effect.

Safety data for Lactulose Fresenius in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision should be made by a qualified healthcare professional after evaluating the clinical situation.

To order Lactulose Fresenius, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lactulose is an osmotic laxative, differing from stimulant laxatives that increase intestinal motility. Compared with polyethylene glycol solutions, lactulose also reduces ammonia absorption, making it the preferred choice for patients with hepatic encephalopathy, whereas other laxatives lack this additional benefit.

Lactulose Fresenius should be stored at ambient temperature, below 25 °C, in its original container. Protect the product from moisture, direct sunlight and extreme temperatures to maintain stability and potency throughout its shelf life.

Lactulose Fresenius is taken orally as a liquid. The prescribed volume is measured using a calibrated device and consumed directly or mixed with a small amount of water or juice, as directed by the healthcare provider.

Serious risks include severe electrolyte disturbances such as hyponatremia or hypokalemia, marked dehydration from excessive diarrhea, and rare allergic reactions. Patients should be monitored for signs of these conditions, especially during high‑dose or prolonged therapy.

Lactulose Fresenius is contraindicated in patients with known hypersensitivity to lactulose or any component of the formulation. Caution is advised in individuals with intestinal obstruction, severe dehydration, or those requiring strict fluid restriction, as the product may exacerbate these conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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