Product image of Lactulose Fresenius (Lactulose, Liquid) supplied by GNH India

Lactulose Fresenius

Active Ingredient:
Lactulose, Liquid
Origin:
EU

Lactulose Fresenius (Lactulose, Liquid)

Lactulose, the active ingredient in Lactulose Fresenius, is an osmotic laxative presented as a liquid for oral use. It is indicated for the treatment of constipation and hepatic encephalopathy in adult patients, helping to soften stools and lower intestinal ammonia levels.

GNH India supplies Lactulose Fresenius as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable sourcing and regulatory‑aligned distribution for healthcare providers. The product complies with EU pharmacopeial standards and is manufactured under GMP conditions.

Manufacturer / TM Owner

Fresenius Kabi Austria Gmbh

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Indications & Clinical Uses

Lactulose is an osmotic laxative used to manage conditions related to bowel motility and ammonia accumulation.

  • Constipation: softens stool and facilitates regular bowel movements.
  • Hepatic encephalopathy: reduces intestinal ammonia absorption, improving neurological status.
  • Hyperammonemia in liver disease: assists in lowering blood ammonia levels.

How It Works

  • Lactulose is a synthetic disaccharide that is not absorbed in the small intestine. In the colon, bacterial enzymes hydrolyze it to short‑chain fatty acids, increasing osmotic pressure and drawing water into the lumen to soften stools. The resulting acidic environment converts ammonia (NH3) to ammonium (NH4+), trapping it in the colon and reducing systemic absorption.

Side Effects

Lactulose may cause several adverse reactions, most of which are related to its laxative action and metabolic effects.

Common Side Effects

  • Diarrhea
  • Abdominal cramping
  • Flatulence
  • Nausea

Serious or Rare Side Effects

  • Severe dehydration
  • Electrolyte disturbances such as hypokalemia

Precautions & Warnings

When prescribing Lactulose Fresenius, clinicians should consider several safety measures.

  • Dose titration: adjust the dose based on stool frequency and individual response.
  • Fluid intake: maintain adequate hydration to prevent dehydration.
  • Electrolyte monitoring: watch for hypokalemia, especially in elderly or renal‑impaired patients.
  • Avoid in intestinal obstruction: risk of perforation and worsening obstruction.
  • Pregnancy and lactation: use only if clearly needed, as safety data are limited.

Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Lactulose can interact with other medicines, requiring attention to avoid reduced efficacy or adverse effects.

Major Interactions (Avoid)

  • Antibiotics such as neomycin or rifaximin: may diminish lactulose's effect by altering gut flora.
  • Other laxatives (e.g., senna, bisacodyl): additive laxative action can cause severe diarrhea.
  • Mineral supplements (e.g., magnesium, calcium carbonate): increase risk of electrolyte imbalance.

Moderate Interactions (Monitor Closely)

  • Diuretics: monitor potassium levels due to potential additive hypokalemia.
  • Insulin or oral hypoglycemics: monitor blood glucose as lactulose may affect carbohydrate absorption.

Frequently Asked Questions

Lactulose Fresenius is prescribed to treat constipation by softening stools and to manage hepatic encephalopathy, a liver‑related neuropsychiatric condition, by lowering intestinal ammonia absorption.

Lactulose is a synthetic sugar that reaches the colon unchanged, where bacterial enzymes break it down into short‑chain fatty acids. This creates an osmotic gradient that draws water into the bowel, softening stool, and the acidic environment converts ammonia to ammonium, reducing its systemic absorption.

The dose of Lactulose Fresenius is individualized by the prescribing clinician. The prescriber determines the appropriate volume based on the patient’s condition, response, and tolerance, and may adjust it to achieve the desired stool frequency or ammonia reduction.

Safety data for Lactulose Fresenius in pregnancy and lactation are limited. It should only be used when clearly needed and after a risk‑benefit assessment by the healthcare professional.

To order Lactulose Fresenius, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lactulose and other osmotic agents such as polyethylene glycol both increase colonic water content. Lactulose additionally acidifies the lumen, which helps trap ammonia, making it the preferred choice for hepatic encephalopathy, whereas polyethylene glycol is often used solely for constipation without the ammonia‑lowering effect.

Lactulose Fresenius should be stored at room temperature, below 25 °C, in its original container. Keep the bottle tightly closed, protect it from moisture and direct sunlight, and ensure it is out of reach of children.

Lactulose Fresenius is an oral liquid taken by mouth. The prescribed volume is measured with a calibrated device such as a dosing cup or syringe, and can be mixed with a small amount of water or juice if needed for palatability.

The most serious risks include severe dehydration and electrolyte disturbances, particularly hypokalemia, which can occur if the dose is too high or fluid intake is insufficient. Monitoring of fluid balance and electrolytes is essential in at‑risk patients.

Lactulose Fresenius is contraindicated in patients with known or suspected intestinal obstruction, perforation, or severe inflammatory bowel disease. Individuals with a hypersensitivity to lactulose or any component of the formulation should also avoid its use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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