Product image of Lactulose Hexal (Lactulose) supplied by GNH India

Lactulose Hexal

Active Ingredient:
Lactulose
Origin:
EU

Lactulose Hexal (Lactulose)

Lactulose, the active ingredient in Lactulose Hexal, is a osmotic laxative presented as an oral formulation for oral use. It is used to treat constipation and to reduce ammonia absorption in patients with hepatic encephalopathy.
GNH India supplies Lactulose Hexal as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Hexal Pharma Gmbh

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Indications & Clinical Uses

Lactulose acts on the gastrointestinal tract to relieve constipation and to manage hepatic encephalopathy.

  • Constipation: softens stool and promotes regular bowel movements.
  • Hepatic encephalopathy: lowers intestinal ammonia levels, helping improve neurological symptoms.

How It Works

  • Lactulose is metabolized by colonic bacteria into short‑chain fatty acids, which lower colonic pH and create an osmotic gradient that retains water in the lumen. This softens feces and stimulates peristalsis. In hepatic encephalopathy, the acidified environment traps ammonia as ammonium, reducing its absorption into the bloodstream.

Side Effects

Lactulose may cause a range of adverse reactions.

Common Side Effects

  • Flatulence: increased gas production in the colon.
  • Abdominal cramping: mild to moderate discomfort.
  • Diarrhea: loose stools, especially at higher doses.
  • Nausea: feeling of queasiness.
  • Bloating: sensation of fullness.
  • Thirst: increased desire for fluids.

Serious or Rare Side Effects

  • Severe electrolyte imbalance: especially low potassium or sodium.
  • Dehydration: significant fluid loss leading to dizziness.
  • Allergic reaction: rash, urticaria, or swelling.
  • Severe abdominal pain: may indicate colonic complications.
  • Hypernatremia: elevated blood sodium in rare cases.

Precautions & Warnings

Before using Lactulose, consider the following precautions.

  • Renal impairment: adjust dose and monitor renal function.
  • Electrolyte monitoring: check serum electrolytes during prolonged therapy.
  • Intestinal obstruction: avoid use if there is a known blockage.
  • Diabetes mellitus: be aware of the sugar content in the solution.
  • Hepatic disease: monitor for worsening encephalopathy.
  • Store at ambient temperature: keep below 25°C, retain in original container, protect from moisture and direct sunlight.

Avoid Interactions

Lactulose can interact with other medicines; awareness helps prevent complications.

Major Interactions (Avoid)

  • Loop diuretics: combined use may exacerbate electrolyte loss.
  • Other osmotic laxatives: concurrent use can increase risk of severe diarrhea and dehydration.

Moderate Interactions (Monitor Closely)

  • Antibiotics altering gut flora (e.g., rifaximin): may affect lactulose metabolism.
  • Oral hypoglycemic agents: monitor blood glucose due to sugar content.
  • Antacids containing magnesium: may increase gastrointestinal side effects.

Frequently Asked Questions

Lactulose Hexal is indicated for the relief of constipation and for the management of hepatic encephalopathy. In constipation, it softens stool and promotes regular bowel movements. In hepatic encephalopathy, it reduces intestinal ammonia absorption, helping improve mental status in patients with liver disease.

Lactulose is a synthetic disaccharide that reaches the colon unchanged, where bacteria ferment it into short‑chain fatty acids. This acidifies the colonic environment, creates an osmotic gradient that retains water in the lumen, and traps ammonia as ammonium, thereby softening stool and lowering systemic ammonia levels.

The dose of Lactulose Hexal is individualized by the prescribing clinician based on the patient’s condition, age, and response. Typical starting regimens may involve a small volume taken once or twice daily, with adjustments made to achieve the desired clinical effect while minimizing side effects.

Safety data for lactulose during pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant. Healthcare providers should discuss the risk‑benefit profile with the patient before initiating therapy.

To order Lactulose Hexal, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Lactulose is an osmotic laxative that works by drawing water into the colon, whereas stimulant laxatives (e.g., bisacodyl) increase intestinal motility, and bulk‑forming agents add fiber to stool. Compared with polyethylene glycol, lactulose also lowers ammonia levels, making it the preferred choice for patients with hepatic encephalopathy.

Lactulose Hexal should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability and potency.

Lactulose Hexal is taken orally. The solution can be measured with a calibrated device and mixed with a small amount of water or other clear fluid if desired. It should be consumed as directed by the prescriber, usually with or without food.

Serious risks include severe dehydration, electrolyte disturbances (especially low potassium or sodium), and rare allergic reactions such as rash or swelling. Patients should be monitored for signs of excessive fluid loss, abdominal pain, or any hypersensitivity, and seek medical attention promptly if these occur.

Lactulose Hexal is contraindicated in individuals with known intestinal obstruction, severe bowel disease that may be aggravated by osmotic agents, or a documented hypersensitivity to lactulose. Caution is also advised for patients with uncontrolled diabetes due to its sugar content and for those with significant renal impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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