Product image of Lactulosum Forte Polfarmex (Lactulose) supplied by GNH India

Lactulosum Forte Polfarmex

Active Ingredient:
Lactulose
Origin:
EU

Lactulosum Forte Polfarmex (Lactulose)

Lactulose, the active ingredient in Lactulosum Forte, is an osmotic laxative presented as a pharmaceutical preparation for oral use. It is employed to relieve constipation and to manage hepatic encephalopathy by reducing ammonia absorption in patients with liver disease.

GNH India supplies Lactulosum Forte as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide, ensuring consistent quality and regulatory compliance across markets.

Manufacturer / TM Owner

Polfarmex S.A.

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Indications & Clinical Uses

Lactulosum Forte acts as an osmotic laxative and ammonia‑lowering agent in the gastrointestinal tract.

  • Constipation: alleviates bowel stasis and promotes regular defecation.
  • Hepatic encephalopathy: lowers blood ammonia levels to improve neurological status.
  • Prevention of hepatic encephalopathy recurrence: maintains reduced ammonia concentrations to help avoid episodic deterioration.

How It Works

  • Lactulose is a synthetic disaccharide that is not absorbed in the small intestine. In the colon it is metabolised by bacterial flora to short‑chain fatty acids, which increase osmotic pressure, draw water into the lumen, and acidify colonic contents. The resulting environment traps ammonia as ammonium ions, reducing its systemic absorption and facilitating bowel evacuation.

Side Effects

Lactulose may cause a range of adverse reactions, most of which are related to its laxative action.

Common Side Effects

  • Abdominal cramping
  • Flatulence
  • Diarrhoea
  • Nausea
  • Bloating
  • Increased thirst

Serious or Rare Side Effects

  • Severe diarrhoea leading to dehydration
  • Electrolyte disturbances (e.g., hyponatraemia, hypokalaemia)
  • Allergic reactions such as rash or angioedema
  • Worsening hepatic encephalopathy in rare cases

Precautions & Warnings

When prescribing Lactulosum Forte, consider the following safety measures.

  • Dose adjustment: in renal impairment, monitor fluid balance and electrolytes.
  • Avoid in galactosemia: lactulose contains galactose residues.
  • Monitor electrolytes: prolonged use may cause shifts in sodium or potassium.
  • Caution in paediatric patients: use only under medical supervision.
  • Pregnancy and lactation: assess risk‑benefit before use.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Lactulosum Forte can interact with other medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Antibiotics such as rifaximin: may diminish lactulose's ammonia‑lowering effect.
  • Other laxatives (e.g., bisacodyl): additive laxative action can cause severe diarrhoea.
  • Diuretics: increased risk of dehydration and electrolyte imbalance.

Moderate Interactions (Monitor Closely)

  • Antacids: may alter colonic pH and affect lactulose activity.
  • Metronidazole: may increase gastrointestinal side effects.
  • Oral hypoglycaemic agents: monitor blood glucose as rapid bowel movements can affect absorption.

Frequently Asked Questions

Lactulosum Forte contains lactulose, an osmotic laxative used to treat constipation and to manage hepatic encephalopathy by lowering blood ammonia levels. It helps restore regular bowel movements and supports neurological function in patients with liver disease.

Lactulose reaches the colon unchanged, where intestinal bacteria ferment it into short‑chain fatty acids. This process increases osmotic pressure, draws water into the bowel, softens stool, and acidifies the lumen, which traps ammonia as ammonium ions, reducing its absorption into the bloodstream.

The appropriate dose of Lactulosum Forte is determined by a qualified prescriber based on the patient’s condition, age, renal function and response to therapy. Dosage may be adjusted during treatment to achieve the desired clinical effect.

Safety data for lactulose in pregnancy and lactation are limited. It should only be used when the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by the treating physician.

To order Lactulosum Forte, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lactulose is an osmotic laxative that works by increasing colonic water content, whereas agents such as polyethylene glycol also draw water but differ in taste and fermentation profile. For hepatic encephalopathy, lactulose is often used alongside rifaximin; lactulose primarily reduces ammonia production, while rifaximin targets gut bacteria.

Lactulosum Forte should be stored at ambient temperature, below 25 °C, in its original container. Keep the product away from moisture and direct sunlight to maintain stability and potency.

Lactulosum Forte is taken orally. The product can be swallowed directly or dissolved in a small amount of water or juice, as directed by the prescriber, to facilitate ingestion and improve palatability.

Serious risks include severe diarrhoea leading to dehydration, significant electrolyte disturbances (such as hyponatraemia or hypokalaemia), and rare allergic reactions like rash or angioedema. Prompt medical attention is required if any of these events occur.

Lactulosum Forte should be avoided in patients with known hypersensitivity to lactulose, those with galactosemia, and individuals in whom rapid fluid loss could be hazardous, such as severe dehydration or uncontrolled electrolyte imbalance, unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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