Product image of Lactulosum Hasco (Lactulose, Liquid) supplied by GNH India

Lactulosum Hasco

Active Ingredient:
Lactulose, Liquid
Origin:
EU

Lactulosum Hasco (Lactulose, Liquid)

Lactulose, the active ingredient in Lactulosum Hasco, is an osmotic laxative presented as a liquid for oral use. It treats constipation and hepatic encephalopathy in adults by softening stools and reducing intestinal ammonia absorption, thereby improving bowel transit and neurological symptoms.

GNH India supplies Lactulosum Hasco as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU quality standards, provides full regulatory documentation, and ensures reliable logistics and consistent product availability for global customers.

Manufacturer / TM Owner

Hasco-Lek

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Indications & Clinical Uses

Lactulose is used as an osmotic laxative to manage conditions related to bowel motility and ammonia metabolism.

  • Constipation: softens stool and promotes regular bowel movements.
  • Hepatic encephalopathy: lowers intestinal ammonia levels, helping to improve neurological function.
  • Prevention of hepatic encephalopathy recurrence: maintains low ammonia concentrations to reduce the risk of symptom relapse.

How It Works

  • Lactulose is a synthetic disaccharide that is not absorbed in the small intestine. In the colon it is metabolized by bacteria into short‑chain fatty acids, which increase the osmotic pressure within the lumen. This draws water into the bowel, softening stool and accelerating transit. The acidic environment also converts ammonia (NH3) to ammonium (NH4+), reducing its absorption and helping to control hepatic encephalopathy.

Side Effects

Lactulose may cause a range of adverse reactions, most of which are related to its osmotic activity in the gut.

Common Side Effects

  • Abdominal bloating: feeling of fullness or distension.
  • Flatulence: increased intestinal gas.
  • Diarrhea: loose, watery stools.
  • Nausea: mild stomach discomfort.
  • Abdominal cramps: intermittent pain.
  • Electrolyte imbalance: mild changes in potassium or sodium levels.

Serious or Rare Side Effects

  • Severe dehydration: excessive fluid loss requiring medical attention.
  • Severe electrolyte disturbances: significant shifts in potassium or sodium that may affect cardiac function.
  • Allergic reactions: rash, itching, or swelling.
  • Severe abdominal pain: persistent or worsening pain.
  • Hepatic decompensation: worsening liver function in susceptible patients.

Precautions & Warnings

Before initiating Lactulosum Hasco, clinicians should consider several safety aspects.

  • Assess renal function: impaired kidneys may affect fluid balance.
  • Monitor electrolytes: especially potassium, during prolonged therapy.
  • Use caution in diabetes: lactulose contains small amounts of carbohydrate.
  • Avoid in intestinal obstruction: risk of perforation.
  • Discontinue if severe diarrhea occurs: to prevent dehydration.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Lactulose can interact with other medicines, requiring attention to avoid reduced efficacy or increased risk.

Major Interactions (Avoid)

  • Antacids containing magnesium or aluminum: may reduce lactulose efficacy.
  • Oral antibiotics: can alter colonic flora and affect lactulose metabolism.
  • Diuretics: increase risk of electrolyte imbalance when combined with lactulose‑induced diarrhea.

Moderate Interactions (Monitor Closely)

  • Other laxatives: additive laxative effect may cause excessive stool loss.
  • Insulin or oral hypoglycemics: lactulose contains trace carbohydrates; monitor blood glucose.
  • Probiotics: may modify gut bacteria and influence lactulose action.

Frequently Asked Questions

Lactulosum Hasco contains lactulose, an osmotic laxative indicated for the relief of constipation and for the management of hepatic encephalopathy. In constipation it softens stools and promotes regular bowel movements, while in hepatic encephalopathy it lowers intestinal ammonia absorption, helping to improve neurological symptoms.

Lactulose is a synthetic sugar that reaches the colon unchanged. Colonic bacteria ferment it into short‑chain fatty acids, which increase the osmotic pressure in the intestinal lumen. This draws water into the bowel, softening the stool and speeding transit. The acidic environment also converts ammonia to ammonium, reducing its absorption and benefiting patients with hepatic encephalopathy.

The dose of Lactulosum Hasco is individualized by the prescribing healthcare professional based on the patient’s condition, age, renal function and response. The prescriber determines the volume and frequency of administration, and patients should follow the written instructions without altering the regimen on their own.

Safety data for lactulose during pregnancy and lactation are limited. It should only be used if the potential benefit outweighs any possible risk to the fetus or infant. Healthcare providers should evaluate each case and discuss potential risks with the patient before initiating therapy.

To request Lactulosum Hasco, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Lactulose is an osmotic laxative that works by increasing colonic water content, similar to polyethylene glycol (PEG) solutions. Compared with PEG, lactulose also reduces intestinal ammonia, making it the preferred choice for patients with hepatic encephalopathy. PEG generally has a faster onset for pure constipation but lacks the ammonia‑lowering effect.

Lactulosum Hasco should be stored at ambient temperature, preferably below 25 °C. Keep the container tightly closed, protect it from moisture and direct sunlight, and retain it in the original packaging until use. Do not freeze the product, and discard any solution that appears discoloured or contaminated.

Lactulosum Hasco is an oral liquid taken by mouth. The prescribed volume is measured with a calibrated dosing device or syringe, then swallowed directly or mixed with a small amount of water or juice if needed. Doses are usually spaced several hours apart, and the solution can be taken with or without food as directed by the prescriber.

Serious risks, though uncommon, include severe dehydration, marked electrolyte disturbances (especially low potassium), allergic reactions such as rash or swelling, and severe abdominal pain. Patients experiencing persistent watery diarrhea, dizziness, or signs of electrolyte imbalance should seek medical attention promptly.

Lactulosum Hasco is contraindicated in patients with known hypersensitivity to lactulose, complete intestinal obstruction, or severe inflammatory bowel disease that could be aggravated by increased bowel activity. Caution is also advised for individuals with renal impairment, uncontrolled diabetes, or those on medications that may interact significantly with lactulose.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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