Product image of Lactulosum Orifarm (Lactulose) supplied by GNH India

Lactulosum Orifarm

Active Ingredient:
Lactulose
Origin:
EU

Lactulosum Orifarm (Lactulose)

Lactulose, the active ingredient in Lactulosum Orifarm, is an osmotic laxative presented as an oral formulation for oral use. It works by increasing the osmotic pressure in the intestinal lumen, drawing water into the bowel and reducing ammonia absorption. Clinically, it is used to relieve constipation and to manage hepatic encephalopathy in patients with liver disease.

GNH India supplies Lactulosum Orifarm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide. The product conforms to European Union quality standards and is manufactured under strict GMP conditions.

Manufacturer / TM Owner

Orifarm Healthcare A/S

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Indications & Clinical Uses

Lactulose is an osmotic laxative that acts on the gastrointestinal tract to treat conditions related to impaired bowel motility and ammonia accumulation.

  • Constipation: softens stools and promotes bowel movements, helping to relieve chronic constipation.
  • Hepatic encephalopathy: lowers blood ammonia levels, improving neurological function in patients with liver‑derived encephalopathy.
  • Prevention of encephalopathy recurrence: maintains low ammonia concentrations to reduce the risk of recurrent episodes in cirrhotic patients.

How It Works

  • Lactulose is a synthetic disaccharide that remains unabsorbed in the small intestine. In the colon, bacterial enzymes hydrolyze it to short‑chain fatty acids, mainly lactic and acetic acid, which lower colonic pH. The acidic environment converts ammonia (NH₃) to ammonium (NH₄⁺), trapping it in the lumen for excretion, while the increased osmotic load draws water into the bowel, softening stool and stimulating peristalsis.

Side Effects

Lactulose may be associated with several adverse reactions, ranging from mild to serious.

Common Side Effects

  • Abdominal cramping
  • Flatulence
  • Diarrhea
  • Nausea
  • Bloating

Serious or Rare Side Effects

  • Severe dehydration
  • Electrolyte disturbances (e.g., hypokalemia)
  • Acute colitis
  • Allergic skin reactions (rash, urticaria)
  • Hypernatremia

Precautions & Warnings

When using Lactulose, several safety considerations should be observed.

  • Dose titration: start with the lowest effective dose and adjust based on clinical response.
  • Fluid intake: maintain adequate hydration to reduce the risk of dehydration.
  • Renal impairment: use with caution in patients with compromised kidney function.
  • Electrolyte monitoring: monitor serum electrolytes during prolonged therapy.
  • Store at ambient temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Lactulose can interact with other medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Antibiotics such as neomycin or rifaximin: may alter colonic flora and diminish lactulose effectiveness.
  • Antidiarrheal agents (e.g., loperamide): can counteract lactulose’s laxative action.
  • Mineral supplements (e.g., magnesium salts): additive osmotic effect may cause severe diarrhea.

Moderate Interactions (Monitor Closely)

  • Diuretics: monitor electrolytes because combined osmotic effects can increase potassium loss.
  • Insulin or oral hypoglycemics: lactulose may affect carbohydrate absorption; blood glucose should be checked regularly.

Frequently Asked Questions

Lactulosum Orifarm contains lactulose, an osmotic laxative indicated for the relief of chronic constipation and for the management of hepatic encephalopathy in patients with liver disease. It helps soften stools and reduces blood ammonia levels, improving neurological symptoms associated with liver‑related encephalopathy.

Lactulose reaches the colon unchanged, where intestinal bacteria break it down into short‑chain fatty acids. These acids lower the colonic pH, converting ammonia to ammonium, which is trapped in the lumen and eliminated. The resulting osmotic effect draws water into the bowel, softening stool and stimulating bowel movements.

The appropriate dose of Lactulosum Orifarm is determined by the prescribing healthcare professional based on the individual’s condition, severity, and response to therapy. Dosing may be adjusted over time to achieve the desired clinical effect while minimizing adverse reactions.

Safety data for lactulose in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision should be made in consultation with a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and assistance with import documentation.

Lactulose is an osmotic laxative, differing from stimulant laxatives that act on intestinal nerves. It provides a gentler, water‑drawing effect and also lowers ammonia levels, making it useful for hepatic encephalopathy—a benefit not shared by most other laxatives. Its onset may be slower, but it is often preferred when both bowel regularity and ammonia reduction are needed.

Lactulosum Orifarm should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

The product is taken orally, usually dissolved in a measured amount of water or other suitable liquid as directed by the prescriber. It can be consumed with or without food, but patients should follow the specific administration instructions provided by their healthcare professional.

Serious risks include severe dehydration, electrolyte imbalances such as hypokalemia, and rare cases of acute colitis or allergic reactions. Patients should be monitored for signs of excessive fluid loss, muscle weakness, or rash, and seek medical attention promptly if these occur.

Lactulose should be avoided in individuals with known hypersensitivity to lactulose or any of its excipients. Caution is also advised for patients with severe renal impairment, intestinal obstruction, or acute abdominal conditions, as the osmotic effect may exacerbate these problems.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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