Product image of Lactulosum Polfarmex (Lactulose) supplied by GNH India

Lactulosum Polfarmex

Active Ingredient:
Lactulose
Origin:
EU

Lactulosum Polfarmex (Lactulose)

Lactulose, the active ingredient in Lactulosum Polfarmex, is an osmotic laxative presented as an oral formulation for oral use. It is used to treat constipation and to reduce ammonia levels in patients with hepatic encephalopathy.
GNH India supplies Lactulosum Polfarmex as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Polfarmex S.A.

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Indications & Clinical Uses

Lactulose acts as an osmotic agent to relieve constipation and to manage hepatic encephalopathy by lowering intestinal ammonia.

  • Constipation: softens stool and promotes bowel movements, helping relieve occasional or chronic constipation.
  • Hepatic encephalopathy: reduces absorption of ammonia from the gut, assisting in the control of neuropsychiatric symptoms in liver disease patients.

How It Works

  • Lactulose reaches the colon unchanged, where colonic bacteria hydrolyze it to short‑chain acids (lactic, acetic, and formic acids). The resulting acidification increases osmotic pressure, drawing water into the lumen, which softens stool and accelerates transit. The acidic environment also converts ammonia (NH3) to ammonium (NH4+), limiting its absorption and lowering systemic ammonia levels.

Side Effects

Lactulose may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Flatulence: increased gas production in the colon.
  • Abdominal cramping: discomfort due to increased intestinal activity.
  • Diarrhea: loose stools from excess osmotic water.
  • Nausea: mild stomach upset.
  • Bloating: sensation of fullness.

Serious or Rare Side Effects

  • Electrolyte imbalance: especially low potassium from prolonged diarrhea.
  • Severe dehydration: excessive fluid loss requiring medical attention.
  • Allergic reaction: rash, itching, or swelling.
  • Hyperosmolar coma: extremely rare, associated with massive fluid shifts.
  • Hepatic encephalopathy worsening: paradoxical increase in ammonia in susceptible individuals.

Precautions & Warnings

Before using Lactulosum Polfarmex, consider the following safety measures.

  • Renal impairment: monitor fluid and electrolyte status closely.
  • Diabetes mellitus: watch for changes in blood glucose due to carbohydrate content.
  • Pediatric use: dosage must be individualized by a pediatric specialist.
  • Pregnancy and lactation: use only if clearly needed and prescribed by a physician.
  • Storage: Store below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Lactulose can interact with several medications, altering their effectiveness or safety profile.

Major Interactions (Avoid)

  • Antacids containing magnesium: may increase the laxative effect and cause diarrhea.
  • Metronidazole: concurrent use can enhance gastrointestinal side effects.

Moderate Interactions (Monitor Closely)

  • Diuretics: risk of electrolyte disturbances, especially potassium loss.
  • Insulin or oral hypoglycemics: carbohydrate content of lactulose may affect glucose control.
  • Antibiotics (broad‑spectrum): may alter gut flora, influencing lactulose metabolism.
  • Proton pump inhibitors: may modify gastric pH, affecting drug absorption.
  • Oral rehydration solutions: monitor total fluid intake to avoid overload.

Frequently Asked Questions

Lactulosum Polfarmex contains lactulose, an osmotic laxative used to relieve constipation and to lower intestinal ammonia in patients with hepatic encephalopathy. It works by drawing water into the colon, softening stool, and converting ammonia to a non‑absorbable form, thereby improving bowel function and neurological symptoms associated with liver disease.

Lactulose reaches the colon unchanged, where bacterial enzymes split it into short‑chain acids. The resulting acidification increases the osmotic gradient, pulling water into the intestinal lumen, which softens stool and speeds transit. The acidic environment also converts ammonia (NH3) into ammonium (NH4+), reducing its absorption into the bloodstream and helping control hepatic encephalopathy.

The dose of Lactulosum Polfarmex is individualized by the prescribing clinician based on the patient’s condition, age, renal function, and response. The prescriber determines the appropriate amount and frequency, and patients should follow the specific instructions provided on the prescription label.

Lactulose is classified as a category C medication in many regions, meaning it should be used only if the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk in small amounts; therefore, lactating mothers should consult their healthcare provider before use.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After the request, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Lactulose is an osmotic laxative, differing from stimulant laxatives (e.g., bisacodyl) that increase intestinal motility. Compared with polyethylene glycol, lactulose also lowers ammonia levels, making it useful for hepatic encephalopathy. Its dual action—laxative effect and ammonia reduction—offers a therapeutic advantage in patients with liver disease.

Lactulosum Polfarmex should be stored below 25 °C in its original container, protected from moisture and direct sunlight. Keep the product out of reach of children and avoid exposing it to extreme temperatures, which could affect its stability and efficacy.

The medication is taken orally, usually as a liquid or powder that is dissolved in water or another suitable beverage. It should be consumed as directed by the prescriber, typically with or without food, and the full dose should be swallowed to ensure proper absorption and effect.

Serious risks include severe dehydration, electrolyte imbalances (especially low potassium), and rare cases of hyperosmolar coma. Patients should monitor for signs of excessive diarrhea, dizziness, or muscle weakness and seek medical attention promptly if these occur.

Individuals with known hypersensitivity to lactulose or its excipients should avoid the product. Patients with severe renal impairment, uncontrolled diabetes, or those who are pregnant without clear medical indication should use it only under close medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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