Product image of Ladinin (Ciprofloxacin) supplied by GNH India

Ladinin

Active Ingredient:
Ciprofloxacin
Origin:
EU

Ladinin (Ciprofloxacin)

Ciprofloxacin, the active ingredient in Ladinin, is a fluoroquinolone presented as an intravenous solution for injection use. It treats a broad range of serious bacterial infections in hospitalized patients, including sepsis, intra‑abdominal infections, and complicated urinary tract infections. It is indicated for severe infections caused by susceptible Gram‑negative and Gram‑positive organisms and is administered under medical supervision.

GNH India supplies Ladinin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU GMP standards and provides reliable cold‑chain logistics for the IV product.

Manufacturer / TM Owner

Pharmathen Investments Group Limited

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Indications & Clinical Uses

Ciprofloxacin is employed to treat infections caused by susceptible bacteria across several organ systems.

  • Severe urinary tract infections: eradicates causative Gram‑negative pathogens and resolves pyelonephritis.
  • Hospital‑acquired pneumonia: provides coverage against typical and atypical respiratory pathogens.
  • Intra‑abdominal infections: targets mixed aerobic and anaerobic bacteria in complicated cases.
  • Skin and soft‑tissue infections: treats cellulitis and wound infections caused by susceptible organisms.
  • Febrile neutropenia: offers broad‑spectrum antibacterial protection in immunocompromised patients.

How It Works

  • Ciprofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. By binding to these enzymes, it prevents the supercoiling and separation of DNA strands, halting bacterial cell division and leading to bacterial cell death. This bactericidal action is effective against a wide range of Gram‑negative and some Gram‑positive organisms.

Side Effects

Ciprofloxacin may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea
  • Diarrhea
  • Headache
  • Rash
  • Dizziness

Serious or Rare Side Effects

  • Tendon rupture or inflammation
  • Clostridioides difficile‑associated colitis
  • QT interval prolongation and cardiac arrhythmias
  • Severe allergic reactions such as anaphylaxis

Precautions & Warnings

Ciprofloxacin requires careful use in specific patient populations and clinical situations.

  • Renal function: adjust dose in patients with impaired renal clearance.
  • Central nervous system: monitor for seizures, especially in patients with pre‑existing CNS disorders.
  • Tendon health: avoid use in individuals with a history of tendon disorders or who are on corticosteroids.
  • Cardiac risk: caution in patients with known QT prolongation or electrolyte abnormalities.
  • Pregnancy and lactation: use only if potential benefits justify the risk to the fetus or infant.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Ciprofloxacin can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Antacids containing magnesium or aluminum: markedly reduce ciprofloxacin absorption.
  • Warfarin: may potentiate anticoagulant effect, increasing INR.
  • Theophylline: ciprofloxacin can raise theophylline plasma levels, risking toxicity.

Moderate Interactions (Monitor Closely)

  • Corticosteroids: combined use raises risk of tendon rupture.
  • Cyclosporine: may increase ciprofloxacin concentrations, requiring monitoring.
  • Diabetes medications: potential alteration of glucose control, necessitating observation.

Frequently Asked Questions

Ladinin contains ciprofloxacin, an IV fluoroquinolone antibiotic used to treat serious bacterial infections such as sepsis, intra‑abdominal infections, complicated urinary tract infections, hospital‑acquired pneumonia, skin and soft‑tissue infections, and febrile neutropenia in hospitalized patients.

Ciprofloxacin blocks bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication and transcription. By inhibiting these targets, the drug prevents bacterial cells from dividing and repairing their DNA, leading to bacterial cell death and resolution of the infection.

The dosage of Ladinin is determined by the prescribing clinician based on the type and severity of infection, patient weight, renal function, and other clinical factors. Specific dosing regimens are not provided here and should follow the prescriber’s order and local guidelines.

The pregnancy category for ciprofloxacin is not definitively established. Use during pregnancy or lactation is only recommended when the potential benefits outweigh the possible risks to the fetus or infant, and it should be decided by the treating physician.

To request Ladinin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain handling for the IV product) and necessary import documentation.

Ladinin (ciprofloxacin) offers broad‑spectrum activity against many Gram‑negative and some Gram‑positive bacteria, with excellent tissue penetration and the convenience of once‑daily IV dosing. Compared with beta‑lactam antibiotics, it may be more effective against resistant Pseudomonas and certain atypical pathogens, but it carries specific risks such as tendon injury and QT prolongation that must be weighed.

Ladinin should be stored at 2‑8 °C in a refrigerator, protected from light, and must not be frozen or shaken. Keep the product in its original packaging until use and follow aseptic techniques during preparation and administration to maintain sterility.

Ladinin is given as an intravenous infusion. The exact infusion rate and duration are set by the prescribing clinician, typically over 30 minutes to 1 hour, and should be administered under medical supervision with appropriate monitoring for adverse reactions.

Serious risks include tendon rupture or tendinitis, Clostridioides difficile‑associated colitis, QT interval prolongation leading to arrhythmias, severe allergic reactions such as anaphylaxis, and central nervous system effects like seizures. Patients should be monitored closely for these events, especially if they have pre‑existing risk factors.

Ladinin should be avoided in patients with a known hypersensitivity to ciprofloxacin or other fluoroquinolones, those with a history of tendon disorders who are also taking corticosteroids, individuals with significant QT prolongation or uncontrolled electrolyte abnormalities, and patients with severe renal impairment unless dose adjustments are made.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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