Product image of Ladinin (Ciprofloxacin Hydrochloride Monohydrate) supplied by GNH India

Ladinin

Active Ingredient:
Ciprofloxacin Hydrochloride Monohydrate
Origin:
EU

Ladinin (Ciprofloxacin Hydrochloride Monohydrate)

Ciprofloxacin Hydrochloride, the active ingredient in Ladinin, is a fluoroquinolone antibiotic presented as an oral formulation for systemic use. It treats a range of bacterial infections in adults, including urinary, respiratory, skin and soft‑tissue, and gastrointestinal infections. It is indicated for use in both community and hospital settings, offering a broad spectrum of activity against Gram‑negative and selected Gram‑positive pathogens.

GNH India supplies Ladinin as a licensed, GDP‑compliant international pharmaceutical product to hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for each batch.

Manufacturer / TM Owner

Pharmathen Investments Group Limited

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Indications & Clinical Uses

Ladinin (ciprofloxacin hydrochloride) is a fluoroquinolone antibiotic used to treat bacterial infections in various organ systems.

  • Urinary tract infection: eradicates susceptible uropathogens, relieving symptoms and preventing complications.
  • Respiratory tract infection: eliminates common respiratory bacteria, aiding recovery from bronchitis and pneumonia.
  • Skin and soft tissue infection: clears susceptible skin pathogens, supporting wound healing.
  • Gastrointestinal infection: targets enteric bacteria, helping resolve dysentery and travel‑related diarrhoea.

How It Works

  • Ciprofloxacin hydrochloride inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA supercoiling and replication. By binding to these enzymes, the drug prevents DNA synthesis and transcription, leading to bacterial cell death. Its activity covers a broad range of Gram‑negative organisms and some Gram‑positive species.

Side Effects

Ciprofloxacin may cause a variety of adverse reactions, ranging from mild to severe.

Common Side Effects

  • Nausea or vomiting: mild gastrointestinal upset.
  • Diarrhea: loose stools that may be self‑limiting.
  • Headache: transient cranial discomfort.
  • Dizziness or light‑headedness: occasional vertiginous sensations.

Serious or Rare Side Effects

  • Tendon rupture or inflammation: sudden pain in tendons, especially the Achilles.
  • Central nervous system effects: seizures, confusion, or hallucinations.
  • Severe allergic reactions: rash, angioedema, or anaphylaxis.

Precautions & Warnings

Before prescribing Ladinin, consider the following precautions to ensure safe use.

  • Renal function: assess kidney function and adjust dose if impairment is present.
  • Allergy history: avoid in patients with known hypersensitivity to fluoroquinolones or related compounds.
  • Tendon health: discontinue if tendon pain, swelling, or inflammation occurs.
  • Central nervous system: monitor patients with a history of seizures or psychiatric disorders.
  • Pregnancy and lactation: use only when the potential benefit justifies the potential risk to the fetus or infant.
  • Store at ambient temperature: keep below 25 °C in the original packaging, protected from moisture and light.

Avoid Interactions

Ciprofloxacin can interact with several medicines; awareness of key interactions helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Antacids containing magnesium or aluminum: significantly reduce ciprofloxacin absorption; separate administration by at least 2 hours.
  • Warfarin: may enhance anticoagulant effect, increasing bleeding risk; monitor INR closely.
  • Theophylline: ciprofloxacin can increase serum theophylline levels, risking toxicity.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): may increase risk of CNS stimulation and seizures.
  • Diabetic agents (e.g., insulin, sulfonylureas): ciprofloxacin may alter glucose control; monitor blood sugar.
  • Corticosteroids: concurrent use may raise the chance of tendon disorders.

Frequently Asked Questions

Ladinin contains ciprofloxacin hydrochloride and is prescribed to treat a variety of bacterial infections, including urinary tract infections, respiratory tract infections such as bronchitis or pneumonia, skin and soft‑tissue infections, and certain gastrointestinal infections caused by susceptible bacteria.

Ciprofloxacin blocks bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication and transcription. Inhibiting these enzymes stops bacterial cells from multiplying, leading to their death and resolution of the infection.

The dosage of Ladinin is determined by the prescribing clinician based on the type and severity of the infection, patient age, weight, kidney function and other clinical factors. No fixed regimen is provided here.

Safety of ciprofloxacin in pregnancy and lactation has not been definitively established. It should be used only if the potential benefit outweighs any possible risk to the fetus or infant, and the decision must be made by a qualified health professional.

To place an order, submit an enquiry on the Ladinin product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ladinin (ciprofloxacin) shares the class‑wide mechanism of DNA gyrase inhibition with other fluoroquinolones such as levofloxacin. Ciprofloxacin generally offers a broader Gram‑negative spectrum, while some newer agents may have enhanced activity against specific resistant strains. Choice depends on susceptibility patterns, infection site and clinician preference.

Ladinin should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight and excessive heat to maintain stability and potency.

Ladinin is taken orally, usually with a full glass of water. The tablet should be swallowed whole and not crushed or chewed unless otherwise directed by a health professional.

Serious adverse events include tendon rupture or inflammation, especially in the Achilles tendon, central nervous system effects such as seizures or severe confusion, and life‑threatening allergic reactions like anaphylaxis. Patients should seek immediate medical attention if any of these occur.

Ladinin should be avoided in individuals with a known hypersensitivity to ciprofloxacin, other fluoroquinolones, or any component of the formulation. It is also contraindicated in patients with a history of tendon disorders related to fluoroquinolone use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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