Product image of Ladose (Fluoxetine) supplied by GNH India

Ladose

Active Ingredient:
Fluoxetine
Origin:
EU

Ladose (Fluoxetine)

Fluoxetine, the active ingredient in Ladose, is a selective serotonin reuptake inhibitor (SSRI) presented as an oral tablet for oral use. It is prescribed to treat depressive and anxiety‑related disorders in adult patients. The medication works by increasing serotonin levels in the brain, which can improve mood, reduce compulsive thoughts, and alleviate panic symptoms.

GNH India supplies Ladose as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. Our distribution network ensures reliable access to quality‑assured products across global markets, adhering to stringent regulatory standards to guarantee product integrity and patient safety.

Manufacturer / TM Owner

Pharmaserve-Lilly Saci

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Indications & Clinical Uses

Fluoxetine is an SSRI that addresses several psychiatric conditions by modulating serotonin pathways.

  • Major depressive disorder: reduces depressive symptoms and improves overall mood.
  • Obsessive‑compulsive disorder: lessens intrusive thoughts and compulsive behaviors.
  • Panic disorder: decreases frequency and intensity of panic attacks.
  • Bulimia nervosa: helps control binge‑eating and purging cycles.
  • Premenstrual dysphoric disorder: alleviates mood swings and physical discomfort associated with the menstrual cycle.

How It Works

  • Fluoxetine selectively inhibits the serotonin transporter (SERT) on presynaptic neurons, blocking reuptake of serotonin (5‑HT) from the synaptic cleft. This results in increased extracellular serotonin concentrations, enhancing serotonergic neurotransmission throughout the central nervous system and contributing to mood stabilization and anxiety reduction.

Side Effects

Fluoxetine may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild gastrointestinal upset.
  • Headache: transient cranial discomfort.
  • Insomnia: difficulty initiating or maintaining sleep.
  • Dry mouth: reduced salivary flow.
  • Sweating: increased perspiration.
  • Sexual dysfunction: decreased libido or delayed orgasm.

Serious or Rare Side Effects

  • Suicidal thoughts: emergence of self‑harm ideation, especially in young adults.
  • Serotonin syndrome: agitation, hyperthermia, tremor, and autonomic instability.
  • Severe allergic reaction: rash, swelling, or anaphylaxis.
  • Abnormal heart rhythm: QT prolongation or arrhythmias.
  • Hyponatremia: low blood sodium causing confusion or seizures.
  • Bleeding disorders: increased risk of gastrointestinal or intracranial hemorrhage.

Precautions & Warnings

When prescribing Fluoxetine, clinicians should consider several precautionary measures to ensure safe use.

  • Assess psychiatric history: monitor for worsening depression or suicidal thoughts.
  • Avoid abrupt discontinuation: taper under medical supervision to reduce withdrawal risk.
  • Use caution in hepatic impairment: dose may require adjustment.
  • Consider drug interactions: review concomitant serotonergic agents.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Fluoxetine interacts with various medicines; some combinations require avoidance while others need careful monitoring.

Major Interactions (Avoid)

  • MAO inhibitors: risk of serotonin syndrome; a 14‑day washout is required.
  • Triptans: increased serotonergic activity may precipitate serotonin syndrome.
  • Linezolid: combined serotonergic effect can be dangerous.
  • St. John’s wort: additive serotonin increase.
  • Pimozide: may cause cardiac arrhythmias.

Moderate Interactions (Monitor Closely)

  • NSAIDs: heightened bleeding risk.
  • Anticoagulants (e.g., warfarin): may enhance anticoagulant effect.
  • Antipsychotics: potential for increased side‑effects.
  • CYP2D6 inhibitors (e.g., quinidine): may raise fluoxetine plasma levels.
  • Alcohol: can exacerbate central nervous system depression.

Frequently Asked Questions

Ladose contains fluoxetine, an SSRI that is indicated for major depressive disorder, obsessive‑compulsive disorder, panic disorder, bulimia nervosa, and premenstrual dysphoric disorder. It helps improve mood, reduce compulsive thoughts, and lessen anxiety‑related symptoms in adult patients.

Fluoxetine blocks the serotonin transporter on presynaptic nerve cells, preventing reuptake of serotonin into the neuron. This increases the amount of serotonin available in the synaptic cleft, enhancing serotonergic signaling throughout the brain, which contributes to mood elevation and anxiety reduction.

The appropriate dose of Ladose is determined by the prescribing clinician based on the individual’s diagnosis, severity of symptoms, age, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.

Safety of fluoxetine during pregnancy and lactation has not been definitively established. Healthcare providers should weigh potential benefits against possible risks and discuss alternative options. Women who are pregnant, planning pregnancy, or breastfeeding should consult their physician before starting or continuing treatment.

To order Ladose, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Ladose (fluoxetine) belongs to the SSRI class, which generally has a favorable side‑effect profile compared with older tricyclic antidepressants and monoamine oxidase inhibitors. It offers once‑daily dosing and a long half‑life, reducing withdrawal symptoms, but individual response varies, and selection should be individualized by a clinician.

Ladose should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the tablets from moisture, direct sunlight, and excessive heat to maintain potency throughout the shelf life.

Ladose is taken orally, usually as a whole tablet swallowed with water. It is typically taken once daily, with or without food, as directed by the prescriber. Patients should not crush or chew the tablet unless specifically instructed.

Serious risks include the emergence of suicidal thoughts or behaviors, especially in young adults, serotonin syndrome when combined with other serotonergic agents, severe allergic reactions, abnormal heart rhythms, hyponatremia, and increased bleeding tendency. Any concerning symptoms should be reported to a healthcare professional immediately.

Ladose is contraindicated in individuals with known hypersensitivity to fluoxetine or any SSRI components, those currently taking monoamine oxidase inhibitors, or patients with a history of severe serotonin syndrome. Caution is also advised for patients with uncontrolled narrow‑angle glaucoma, severe hepatic impairment, or those on contraindicated medications.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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