Product image of Ladybon (Tibolone) supplied by GNH India

Ladybon

Active Ingredient:
Tibolone
Origin:
EU

Ladybon (Tibolone)

Tibolone, the active ingredient in Ladybon, is a synthetic steroid presented as an oral formulation for systemic use. It is prescribed to alleviate menopausal symptoms and to help maintain bone density in post‑menopausal women.
GNH India supplies Ladybon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Q Pharma Kft.

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Indications & Clinical Uses

  • Ladybon (tibolone) is used within hormone replacement therapy to address conditions linked to menopause and bone health.
  • Menopausal symptoms: reduces hot flashes, night sweats and mood swings in post‑menopausal women.
  • Osteoporosis prevention: improves bone mineral density and reduces fracture risk in post‑menopausal patients.
  • Hormone replacement therapy: provides combined estrogenic, progestogenic and androgenic activity for overall symptom control.

How It Works

  • Tibolone binds to estrogen, progesterone and androgen receptors, exerting estrogenic, progestogenic and androgenic effects. This mixed hormonal activity modulates the hypothalamic‑pituitary‑gonadal axis, alleviating vasomotor symptoms, supporting endometrial stability and enhancing bone remodeling by reducing osteoclast activity and promoting osteoblast function.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Nausea: occasional gastrointestinal upset.
  • Breast tenderness: transient discomfort.
  • Mood changes: irritability or mild depression.

Serious or Rare Side Effects

  • Venous thromboembolism: risk of deep vein thrombosis or pulmonary embolism.
  • Liver dysfunction: abnormal liver enzymes or hepatitis.
  • Hormone‑dependent cancers: potential increase in breast or endometrial cancer risk.

Precautions & Warnings

Before initiating therapy, clinicians should evaluate individual risk factors and monitor patients regularly.

  • Cardiovascular assessment: review history of thrombosis or stroke.
  • Liver function monitoring: perform baseline and periodic liver enzyme tests.
  • Breast evaluation: conduct regular clinical breast exams and imaging as indicated.
  • Bone health review: assess baseline bone mineral density.
  • Pregnancy contraindication: avoid use in pregnant or breastfeeding women.
  • Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Tibolone may interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Combined oral contraceptives: may increase thrombotic risk.
  • Anticoagulants: potential for altered clotting parameters.

Moderate Interactions (Monitor Closely)

  • SSRIs: may diminish vasomotor symptom relief.
  • Antihypertensives: possible additive blood pressure effects.
  • Thyroid hormone replacement: may require dose adjustment.

Frequently Asked Questions

Ladybon contains tibolone and is used to treat moderate to severe menopausal symptoms such as hot flashes, night sweats, and mood changes, as well as to help prevent osteoporosis in post‑menopausal women by improving bone mineral density.

Tibolone binds to estrogen, progesterone and androgen receptors, providing a balanced hormonal effect. This mixed activity reduces vasomotor symptoms, supports endometrial stability, and promotes bone formation while limiting bone resorption.

The dosage of Ladybon is determined by the prescribing clinician based on the individual’s health status, severity of symptoms, and treatment goals. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Ladybon is contraindicated in pregnancy and breastfeeding. Tibolone can affect fetal development and is not recommended for nursing mothers because it may pass into breast milk and influence the infant.

To order Ladybon, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Unlike traditional estrogen‑only or combined estrogen‑progestogen therapies, tibolone offers estrogenic, progestogenic and androgenic actions in a single molecule. This can provide broader symptom control and bone benefits, but the safety profile differs, especially regarding thrombotic and cancer risks, which should be weighed against alternative options.

Ladybon should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight and excessive heat to maintain its stability and potency.

Ladybon is taken orally, usually as a tablet, with or without food as directed by the prescriber. The exact administration schedule is individualized, and patients should follow the dosing instructions provided by their healthcare professional.

Serious risks include venous thromboembolism, stroke, liver dysfunction, and an increased potential for hormone‑dependent cancers such as breast or endometrial cancer. Patients should be monitored regularly for signs of these conditions, and therapy should be discontinued if serious adverse events occur.

Ladybon should not be used by women who are pregnant, breastfeeding, have a history of hormone‑sensitive cancers, active liver disease, unexplained vaginal bleeding, or who have experienced thromboembolic events. Contraindications also include known hypersensitivity to tibolone or any excipients in the formulation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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