Product image of Ladybon (Tibolone) supplied by GNH India

Ladybon

Active Ingredient:
Tibolone
Origin:
EU

Ladybon (Tibolone)

Tibolone, the active ingredient in Ladybon, is a synthetic steroid (estrogenic, progestogenic, androgenic) presented as an oral tablet for oral use. It treats menopausal symptoms and estrogen deficiency in post‑menopausal women.

GNH India supplies Ladybon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zentiva, K.S.

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Indications & Clinical Uses

Tibolone is used in hormone replacement therapy to address estrogen deficiency.

  • Relief of menopausal symptoms: reduces hot flashes, night sweats, and mood swings.
  • Prevention of post‑menopausal osteoporosis: improves bone mineral density.
  • Treatment of estrogen deficiency: restores hormonal balance in post‑menopausal women.
  • Management of vulvovaginal atrophy: alleviates dryness and discomfort.

How It Works

  • Tibolone acts as a synthetic steroid that binds to estrogen, progesterone, and androgen receptors. Its metabolites display estrogenic activity in bone and brain, progestogenic activity in the endometrium, and androgenic activity in peripheral tissues, collectively alleviating menopausal symptoms and supporting bone health.

Side Effects

Tibolone may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Nausea: mild gastrointestinal upset.
  • Headache: transient cranial discomfort.
  • Breast tenderness: mild swelling or pain.
  • Weight gain: modest increase in body weight.

Serious or Rare Side Effects

  • Venous thromboembolism: risk of blood clots.
  • Liver dysfunction: abnormal liver enzyme levels.
  • Severe hypertension: significant increase in blood pressure.

Precautions & Warnings

Before initiating tibolone therapy, several safety considerations are recommended.

  • Assess cardiovascular risk: evaluate history of thromboembolic disease.
  • Monitor liver function: perform baseline and periodic tests.
  • Screen for estrogen‑dependent tumors: avoid in known breast or endometrial cancer.
  • Consider bone health: use with calcium/vitamin D as needed.
  • Store at ambient temperature: keep below 25°C in the original pack, protect from moisture.

Avoid Interactions

Tibolone can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Combined oral contraceptives: increased risk of thromboembolism.
  • Anticoagulants (warfarin): may potentiate bleeding risk.
  • Antihypertensives: may reduce efficacy.

Moderate Interactions (Monitor Closely)

  • Cytochrome P450 inducers (e.g., rifampin): may lower tibolone levels.
  • Antidepressants (SSRIs): may affect hot‑flash relief.

Frequently Asked Questions

Ladybon contains tibolone and is prescribed to relieve menopausal symptoms such as hot flashes, night sweats, and mood changes, as well as to treat estrogen deficiency and help prevent post‑menopausal bone loss in women.

Tibolone is converted into metabolites that bind to estrogen, progesterone, and androgen receptors. This mixed hormonal activity provides estrogenic effects on bone and brain, progestogenic effects on the endometrium, and androgenic effects on peripheral tissues, collectively easing menopausal symptoms.

The dosage of Ladybon is determined by the prescribing clinician based on the individual’s medical condition, age, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Ladybon is not recommended for use during pregnancy or while breastfeeding because tibolone can affect hormonal balance. Women who are pregnant, planning to become pregnant, or nursing should discuss alternative treatments with their healthcare provider.

To order Ladybon, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and necessary import documentation.

Unlike traditional estrogen‑only or combined estrogen‑progestogen products, tibolone offers a unique triple‑action profile (estrogenic, progestogenic, androgenic). This can provide broader symptom relief and bone protection, but the safety profile differs, especially regarding thromboembolic risk, which should be evaluated against alternatives.

Ladybon should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Ladybon is taken orally, usually as a tablet, with or without food. The exact timing and frequency are set by the prescriber, and patients should swallow the tablet whole with water as directed.

The most serious risks include venous thromboembolism, severe hypertension, and liver dysfunction. Patients should be monitored for signs of blood clots, sudden high blood pressure, or abnormal liver tests, and seek immediate medical attention if these occur.

Ladybon is contraindicated in women with a history of breast or endometrial cancer, active liver disease, unexplained vaginal bleeding, or known thromboembolic disorders. It should also be avoided in pregnant or breastfeeding women.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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