Product image of Laevolac Arome Prune (Lactulose, Liquid) supplied by GNH India

Laevolac Arome Prune

Active Ingredient:
Lactulose, Liquid
Origin:
EU

Laevolac Arome Prune (Lactulose, Liquid)

Lactulose, the active ingredient in Laevolac Arome Prune, is an osmotic laxative presented as a liquid for oral use. It treats constipation and helps prevent hepatic encephalopathy in patients with liver disease.\n\nGNH India supplies Laevolac Arome Prune as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Fresenius Kabi Austria Gmbh

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Indications & Clinical Uses

  • Lactulose is employed as an osmotic laxative to manage bowel motility disorders and hepatic encephalopathy.\n\n- Constipation: softens stools and promotes regular bowel movements.\n- Hepatic encephalopathy: lowers blood ammonia levels, reducing the risk of neuro‑cognitive episodes.\n- Portal‑systemic encephalopathy: assists in ammonia trapping, supporting liver‑related neurological health.

How It Works

  • Lactulose is a synthetic disaccharide that is minimally absorbed in the small intestine. When it reaches the colon, bacterial enzymes hydrolyze it to short‑chain fatty acids, lowering colonic pH. The acidic environment converts ammonia (NH3) to ammonium (NH4+), which is trapped and excreted, while the increased osmotic pressure draws water into the lumen, softening stool and stimulating peristalsis.

Side Effects

  • Lactulose may cause a range of adverse reactions, most of which are mild and transient.\n\nCommon Side Effects:\n- Abdominal cramping\n- Flatulence\n- Diarrhea\n- Nausea\n- Bloating\n- Increased thirst\n\nSerious or Rare Side Effects:\n- Severe electrolyte imbalance (e.g., hyponatremia)\n- Dehydration\n- Allergic reaction (rash, itching, swelling)\n- Persistent abdominal pain\n- Hepatic decompensation in advanced liver disease

Precautions & Warnings

  • When using lactulose, certain precautions help ensure safety and effectiveness.\n\n- Dose adjustment: modify dose in renal impairment and monitor electrolytes.\n- Fluid intake: maintain adequate hydration to reduce risk of dehydration.\n- Electrolyte monitoring: watch for hyponatremia or potassium shifts during prolonged therapy.\n- Pregnancy: safety not established; use only if clearly needed after risk‑benefit assessment.\n- Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

  • Lactulose can interact with other medicines, affecting its efficacy or safety.\n\nMajor Interactions (Avoid):\n- Antibiotics such as rifaximin: may reduce lactulose’s ammonia‑trapping effect.\n- Antidiarrheal agents (e.g., loperamide): can counteract the laxative action.\n- Mineral oil: may interfere with colonic fermentation of lactulose.\n\nModerate Interactions (Monitor Closely):\n- Diuretics: increase risk of electrolyte disturbances; monitor serum levels.\n- Insulin or oral hypoglycemics: lactulose may affect glucose control; observe blood sugar.\n- Probiotics: may enhance gas production, leading to increased flatulence.

Frequently Asked Questions

Laevolac Arome Prune contains lactulose, an osmotic laxative used to relieve constipation and to prevent or treat episodes of hepatic encephalopathy in patients with liver disease by reducing blood ammonia levels.

Lactulose reaches the colon unchanged, where bacterial fermentation produces short‑chain acids that lower colonic pH. This acidic environment converts ammonia to ammonium, which is trapped and eliminated, while the increased osmotic pressure draws water into the bowel, softening stool and promoting evacuation.

The prescribed dose of lactulose is individualized by the treating clinician based on the patient’s condition, severity, and response. Dosage may be adjusted to achieve the desired clinical effect while minimizing adverse reactions.

Safety data for lactulose in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision should be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Unlike stimulant laxatives that act on intestinal nerves, lactulose works osmotically and also lowers colonic ammonia, making it useful for both constipation and hepatic encephalopathy. It is generally gentler on the bowel but may cause more gas and bloating compared with bulk‑forming agents.

Store the liquid at ambient temperature, preferably below 25 °C, in its original container. Protect it from moisture, direct sunlight and extreme temperatures to maintain stability and potency.

The product is taken orally as a liquid. It can be measured with a calibrated dosing device and mixed with a small amount of water or juice if needed, following the prescribing clinician’s instructions.

Serious risks include severe electrolyte imbalance, dehydration, and rare allergic reactions. Patients with advanced liver disease should be monitored closely for signs of hepatic decompensation while on therapy.

Lactulose is contraindicated in patients with known hypersensitivity to lactulose or any component of the formulation, and it should be used with caution in individuals with severe renal impairment, intestinal obstruction, or active gastrointestinal bleeding.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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