Product image of Laevolac (Lactulose) supplied by GNH India

Laevolac

Active Ingredient:
Lactulose
Origin:
EU

Laevolac (Lactulose)

Lactulose, the active ingredient in Laevolac, is a osmotic laxative presented as an oral formulation for oral use. It is employed to relieve constipation and to manage hepatic encephalopathy by reducing intestinal ammonia absorption.
GNH India supplies Laevolac as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Chiesi Italia S.P.A.

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Indications & Clinical Uses

Laevolac is an osmotic laxative that acts on the gastrointestinal tract to treat specific conditions.

  • Constipation: provides osmotic laxation to facilitate regular bowel movements in patients with infrequent or difficult stools.
  • Hepatic encephalopathy: lowers intestinal ammonia production and absorption, helping to control neuropsychiatric symptoms in liver disease.

How It Works

  • Lactulose is a synthetic disaccharide that is not absorbed in the small intestine. When it reaches the colon, bacterial enzymes hydrolyze it to short‑chain fatty acids, lowering colonic pH and increasing osmotic pressure. This draws water into the lumen, softening stool and stimulating peristalsis, while the acidic environment traps ammonia as ammonium, reducing its systemic absorption.

Side Effects

Lactulose may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Flatulence: increased gas production due to bacterial fermentation.
  • Abdominal cramps: mild colicky pain during bowel movements.
  • Diarrhoea: loose stools if dose exceeds tolerance.
  • Nausea: occasional feeling of queasiness.

Serious or Rare Side Effects

  • Severe electrolyte imbalance: especially low potassium or sodium levels.
  • Dehydration: excessive fluid loss from prolonged diarrhoea.
  • Allergic reaction: rash, itching, or swelling.
  • Severe abdominal pain: may indicate obstruction or intolerance.

Precautions & Warnings

Before using Laevolac, consider the following safety measures.

  • Dose titration: adjust the amount based on stool frequency and patient tolerance.
  • Electrolyte monitoring: watch for potassium or sodium disturbances during extended therapy.
  • Renal impairment: use cautiously as electrolyte shifts can be more pronounced.
  • Diabetes: monitor blood glucose, as lactulose may affect sugar levels.
  • Store at room temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Lactulose can interact with other medicines, requiring attention to avoid reduced efficacy or increased risk.

Major Interactions (Avoid)

  • Broad‑spectrum antibiotics: may diminish colonic bacterial activity, reducing lactulose effectiveness.
  • Antidiarrhoeal agents: can counteract the laxative action of lactulose.

Moderate Interactions (Monitor Closely)

  • Mineral supplements: may alter electrolyte balance when combined with lactulose.
  • Diuretics: increase risk of dehydration and electrolyte loss.
  • Insulin or oral hypoglycaemic drugs: monitor glucose levels as lactulose can affect carbohydrate metabolism.

Frequently Asked Questions

Laevolac contains lactulose, which is used primarily to treat constipation and to manage hepatic encephalopathy. In constipation, it softens stool and promotes regular bowel movements. In hepatic encephalopathy, it reduces the absorption of ammonia from the gut, helping to control neurological symptoms associated with liver disease.

Lactulose is a synthetic sugar that reaches the colon unchanged, where gut bacteria break it down into short‑chain fatty acids. This process lowers the colonic pH and creates an osmotic gradient that draws water into the bowel, softening stool and stimulating peristalsis. The acidic environment also traps ammonia as ammonium, decreasing its absorption into the bloodstream.

The dose of Laevolac is individualized and determined by the prescribing healthcare professional. The prescriber will consider the patient’s condition, severity, response to therapy, and any underlying health issues before setting the appropriate dosage and titration schedule.

Safety data for lactulose in pregnancy and lactation are limited. It is generally classified as a category C medication, meaning risk cannot be ruled out. Women who are pregnant or breastfeeding should discuss potential benefits and risks with their physician before using Laevolac.

To place an order, submit an enquiry on the Laevolac product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, and will request trade or institutional credentials. After verification, the team provides pricing, availability, shipping details (including any cold‑chain requirements), and assists with import documentation.

Laevolac (lactulose) is an osmotic laxative that works by increasing water content in the colon, whereas stimulant laxatives such as bisacodyl act by directly stimulating intestinal nerves. Polyethylene glycol (PEG) is another osmotic agent but does not produce the same acidifying effect that reduces ammonia absorption, making lactulose the preferred choice for hepatic encephalopathy.

Laevolac should be stored at room temperature, below 25 °C. Keep the product in its original packaging, protect it from moisture and direct heat, and ensure the container is tightly closed to maintain stability.

Laevolac is taken orally. The powder or liquid formulation is usually dissolved in a small amount of water or other clear fluid and consumed as directed by the prescriber. It can be taken with or without food, but consistent timing helps achieve predictable results.

The most serious risks include severe electrolyte disturbances (particularly low potassium or sodium), dehydration from excessive diarrhoea, and rare allergic reactions such as rash or swelling. Patients should seek medical attention if they experience persistent vomiting, severe abdominal pain, or signs of electrolyte imbalance.

Laevolac is contraindicated in individuals with known hypersensitivity to lactulose, intestinal obstruction, perforated bowel, or acute abdominal conditions. It should also be used with caution in patients with severe renal impairment, as they may be more susceptible to electrolyte imbalances.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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