Product image of Laevolac (Lactulose, Liquid) supplied by GNH India

Laevolac

Active Ingredient:
Lactulose, Liquid
Origin:
EU

Laevolac (Lactulose, Liquid)

Lactulose, the active ingredient in Laevolac, is an osmotic laxative presented as a liquid solution for oral use. It is employed to soften stools in constipation and to reduce ammonia absorption in patients at risk of hepatic encephalopathy. It is widely used in adult and pediatric populations under medical supervision.

GNH India supplies Laevolac as a licensed, GDP‑compliant international pharmaceutical supplier, sourcing the product from EU markets and serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide. All shipments adhere to stringent quality standards and regulatory requirements.

Manufacturer / TM Owner

Fresenius Kabi Austria Gmbh

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Indications & Clinical Uses

Lactulose, an osmotic laxative, is used to manage conditions related to bowel motility and hepatic ammonia accumulation.

  • Constipation: softens stools and promotes regular bowel movements.
  • Hepatic encephalopathy: lowers colonic ammonia production, helping to prevent or treat episodes in patients with liver disease.
  • Hyperammonemia: reduces blood ammonia levels in individuals with liver dysfunction.

How It Works

  • Lactulose is a synthetic disaccharide that reaches the colon unchanged, where bacterial β‑galactosidase enzymes hydrolyze it to short‑chain acids such as lactic and acetic acid. The resulting acidification creates an osmotic gradient that retains water in the lumen, softening stool, and lowers colonic pH, which converts ammonia (NH3) to non‑absorbable ammonium (NH4+), thereby decreasing systemic ammonia levels.

Side Effects

Lactulose may cause a range of gastrointestinal and metabolic reactions, most of which are mild and transient.

Common Side Effects

  • Abdominal bloating
  • Diarrhea
  • Flatulence
  • Nausea

Serious or Rare Side Effects

  • Severe electrolyte imbalance
  • Dehydration
  • Allergic reaction (rash, itching)

Precautions & Warnings

When using Laevolac, consider the following safety measures.

  • Dose titration: start with the lowest effective volume and adjust based on stool response.
  • Fluid intake: maintain adequate hydration to prevent dehydration.
  • Electrolyte monitoring: check serum electrolytes in patients with renal or cardiac disease.
  • Avoid in complete bowel obstruction: risk of perforation.
  • Pregnancy and lactation: use only if clearly needed after risk‑benefit assessment.
  • Store at ambient temperature: keep below 25 °C, in original container, protect from moisture and light.

Avoid Interactions

Lactulose can interact with several medicines; awareness helps maintain efficacy and safety.

Major Interactions (Avoid)

  • Antibiotics (e.g., rifaximin): may reduce lactulose fermentation, diminishing efficacy.
  • Laxatives (e.g., senna): additive laxative effect, risk of diarrhea.

Moderate Interactions (Monitor Closely)

  • Diuretics: increased risk of electrolyte disturbances.
  • Mineral supplements (e.g., calcium, magnesium): may bind lactulose, reducing effect.
  • Insulin or oral hypoglycemics: lactulose can affect glucose absorption, monitor blood sugar.

Frequently Asked Questions

Laevolac contains lactulose, an osmotic laxative indicated for the relief of constipation and for the prevention or treatment of hepatic encephalopathy in patients with liver disease. It works by softening stools and reducing intestinal ammonia absorption.

Lactulose reaches the colon unchanged, where bacterial enzymes break it down into short‑chain acids. This acidifies the colonic environment, creating an osmotic pull that retains water in the lumen, softening stool, and converts ammonia to ammonium, which is less readily absorbed, thereby lowering blood ammonia levels.

The dose of Laevolac is individualized by the prescribing clinician based on the patient’s condition, age, and response. Typically, treatment starts with a low volume and is adjusted until the desired stool consistency or ammonia reduction is achieved.

Lactulose is classified as a pregnancy category that requires careful risk‑benefit assessment. It may be used during pregnancy or lactation only when clearly needed and prescribed by a qualified health professional.

To request Laevolac, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with polyethylene glycol‑based laxatives, lactulose also lowers colonic ammonia, offering a dual benefit for patients with liver disease. Polyethylene glycol primarily acts as an osmotic agent without affecting ammonia metabolism, making lactulose the preferred choice when hepatic encephalopathy risk is present.

Store Laevolac at ambient temperature, preferably below 25 °C, in its original container. Protect the liquid from moisture and direct sunlight. Do not freeze; keep the bottle tightly closed to maintain stability.

Laevolac is taken orally as a liquid solution. The prescribed volume is measured with a calibrated dosing device and ingested directly or mixed with a small amount of water or juice, according to the healthcare provider’s instructions.

Serious risks include severe electrolyte imbalance, dehydration, and rare allergic reactions such as rash or itching. Patients should be monitored for signs of these events, especially if high doses are used or if they have underlying renal or cardiac conditions.

Laevolac should be avoided in individuals with complete bowel obstruction, known hypersensitivity to lactulose, or in those where rapid fluid loss could be hazardous without close medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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