Product image of Laevolac (Lactulose, Liquid) supplied by GNH India

Laevolac

Active Ingredient:
Lactulose, Liquid
Origin:
EU

Laevolac (Lactulose, Liquid)

Lactulose, the active ingredient in Laevolac, is an osmotic laxative presented as a liquid for oral use. It is employed to relieve constipation and to reduce blood ammonia levels in patients with hepatic encephalopathy, under the guidance of a qualified healthcare professional. It is available in a ready‑to‑drink formulation that can be measured and mixed according to prescriber instructions.

GNH India supplies Laevolac as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent product availability, regulatory compliance and reliable logistics across EU and other markets.

Manufacturer / TM Owner

Fresenius Kabi Hungary Kft.

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Indications & Clinical Uses

  • Laevolac (lactulose) acts as an osmotic laxative and ammonia‑lowering agent in the gastrointestinal tract.
  • Constipation: softens stool and promotes bowel movements, helping relieve occasional or chronic constipation.
  • Hepatic encephalopathy: lowers intestinal ammonia production, assisting in the management of hepatic encephalopathy in patients with liver disease.

How It Works

  • Lactulose is a synthetic disaccharide that is not absorbed in the small intestine. In the colon, bacterial enzymes hydrolyze it to short‑chain fatty acids, primarily lactic and acetic acid, which increase the osmotic pressure and draw water into the lumen, softening stool. The acidification of colonic contents also converts ammonia (NH3) to ammonium (NH4+), reducing its absorption and systemic levels.

Side Effects

Lactulose may cause a range of adverse reactions, most of which are related to its osmotic activity in the gut.

Common Side Effects

  • Bloating: abdominal distension and discomfort.
  • Diarrhea: loose stools, especially with higher doses.
  • Nausea: mild queasiness.
  • Flatulence: increased intestinal gas.

Serious or Rare Side Effects

  • Electrolyte imbalance: significant changes in potassium or sodium levels.
  • Severe abdominal pain: may indicate intestinal obstruction.
  • Allergic reaction: rash, itching, or swelling.
  • Dehydration: marked fluid loss leading to low blood pressure.

Precautions & Warnings

When using Laevolac, certain precautions should be observed to ensure safety and effectiveness.

  • Dose adjustment: tailor the dose to individual response and clinical condition.
  • Fluid intake: maintain adequate hydration to reduce risk of dehydration.
  • Renal impairment: monitor kidney function and adjust dosing if necessary.
  • Diabetes: monitor blood glucose as lactulose may affect glucose metabolism.
  • Pediatric use: use under pediatric specialist guidance, dosing differs from adults.
  • Store at ambient temperature: keep below 25°C, retain in original container, protect from moisture.

Avoid Interactions

Lactulose can interact with other medicines, affecting their absorption or therapeutic effect.

Major Interactions (Avoid)

  • Antacids containing magnesium or aluminum: may reduce lactulose efficacy by binding.
  • Oral antibiotics: broad‑spectrum agents can alter gut flora, diminishing lactulose metabolism.

Moderate Interactions (Monitor Closely)

  • Diuretics: increased risk of electrolyte disturbances when combined with lactulose‑induced diarrhea.
  • Insulin or oral hypoglycemics: monitor blood glucose as lactulose may affect glucose levels.
  • Proton pump inhibitors: may modify gastric pH and influence lactulose activity.

Frequently Asked Questions

Laevolac contains lactulose, an osmotic laxative that is used to relieve constipation and to lower elevated blood ammonia levels in patients with hepatic encephalopathy. It works by drawing water into the colon and by acidifying the intestinal contents, which helps manage these conditions under medical supervision.

Lactulose is a synthetic sugar that is not absorbed in the small intestine. In the colon, bacteria break it down into short‑chain fatty acids, increasing osmotic pressure and pulling water into the bowel to soften stool. The resulting acidic environment also converts ammonia to ammonium, reducing its absorption into the bloodstream.

The dose of Laevolac is individualized by the prescribing clinician based on the patient’s age, condition, and response. Typical regimens start with a low dose that is gradually adjusted to achieve the desired effect, whether relieving constipation or managing hepatic encephalopathy. Exact dosing instructions should always come from a qualified healthcare professional.

Safety data for lactulose in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss the use of Laevolac with their healthcare provider before starting therapy.

To order Laevolac, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the sales team provides pricing, availability, shipping details and any necessary import documentation.

Laevolac (lactulose) is an osmotic laxative that works by increasing colonic water content and lowering ammonia levels, which distinguishes it from stimulant laxatives such as bisacodyl. Compared with polyethylene glycol (PEG) solutions, lactulose also offers the benefit of ammonia reduction, making it the preferred choice for patients with hepatic encephalopathy.

Laevolac should be stored at ambient temperature, preferably below 25 °C. Keep the container tightly closed, protect it from moisture and direct sunlight, and retain it in the original packaging until use. Do not freeze the product, and discard any solution that appears discolored or contains particles.

Laevolac is taken orally as a liquid. The prescribed dose is measured with a calibrated spoon or syringe and can be mixed with a small amount of water, juice, or other non‑carbonated beverage if desired. It should be consumed as directed by the prescriber, typically once or twice daily, with or without food.

Serious risks, though uncommon, include electrolyte imbalances such as low potassium or sodium, severe abdominal pain that may signal intestinal obstruction, and allergic reactions presenting as rash, itching, or swelling. Patients should seek immediate medical attention if they experience any of these symptoms while using Laevolac.

Laevolac should be avoided in individuals with known hypersensitivity to lactulose, those with intestinal blockage, severe renal impairment, or active gastrointestinal disease that could be worsened by increased bowel motility. Pregnant or breastfeeding women should use it only after consulting a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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