Product image of Laevolac (Lactulose, Liquid) supplied by GNH India

Laevolac

Active Ingredient:
Lactulose, Liquid
Origin:
EU

Laevolac (Lactulose, Liquid)

Lactulose, the active ingredient in Laevolac, is an osmotic laxative presented as a liquid for oral use. It treats constipation and hepatic encephalopathy by drawing water into the colon and reducing ammonia absorption, and is employed in adult and pediatric patients as appropriate. It is indicated for short‑term relief of constipation and for long‑term management of hepatic encephalopathy, helping to lower blood ammonia levels and improve neurological status.

GNH India supplies Laevolac as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality assurance, regulatory compliance and reliable logistics across multiple markets.

Manufacturer / TM Owner

Fresenius Kabi Austria Gmbh

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Indications & Clinical Uses

Laevolac (lactulose) is used to manage conditions related to bowel motility and ammonia accumulation.

  • Constipation: softens stools and promotes regular bowel movements by increasing colonic water content.
  • Hepatic encephalopathy: lowers blood ammonia levels by acidifying the colon, facilitating ammonia trapping and excretion.
  • Prevention of hepatic encephalopathy recurrence: maintains low ammonia concentrations to reduce the risk of episodic neurocognitive decline.

How It Works

  • Lactulose is a synthetic disaccharide that is not absorbed in the small intestine. In the colon bacterial enzymes hydrolyze it to short‑chain fatty acids, which increase osmotic pressure and draw water into the lumen. The resulting acidification lowers colonic pH, converting ammonia (NH3) to ammonium (NH4+), which is trapped and eliminated, thereby reducing systemic ammonia levels in patients with liver disease significantly.

Side Effects

Lactulose may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Flatulence: increased gas production in the colon.
  • Abdominal cramps: intermittent discomfort or pain.
  • Diarrhea: loose stools, especially with higher doses.

Serious or Rare Side Effects

  • Severe electrolyte imbalance: hyponatremia or hypokalemia.
  • Severe dehydration: excessive fluid loss leading to hypotension.
  • Allergic reaction: rash, urticaria, or angioedema.

Precautions & Warnings

When prescribing Laevolac, clinicians should consider several safety measures.

  • Dose titration: adjust dose based on stool frequency and consistency.
  • Electrolyte monitoring: check serum electrolytes in patients with renal impairment or on diuretics.
  • Renal function assessment: use cautiously in severe renal failure.
  • Diabetes monitoring: lactulose may affect blood glucose; monitor levels.
  • Discontinuation: avoid abrupt cessation to prevent rebound constipation.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Lactulose can interact with other medicines, requiring attention to avoid reduced efficacy or increased risk.

Major Interactions (Avoid)

  • Antidiarrheal agents (e.g., loperamide): may counteract lactulose’s laxative effect.
  • Mineral oil: can interfere with lactulose’s action and absorption.

Moderate Interactions (Monitor Closely)

  • Broad‑spectrum antibiotics: may alter gut flora and affect lactulose metabolism.
  • Diabetes medications: monitor blood glucose as lactulose can affect glycemic control.
  • Loop diuretics: increased risk of electrolyte disturbances; monitor electrolytes.

Frequently Asked Questions

Laevolac contains lactulose, an osmotic laxative indicated for the relief of constipation and for the management of hepatic encephalopathy. In constipation it softens stools and promotes regular bowel movements, while in hepatic encephalopathy it helps lower blood ammonia levels to improve neurological function.

Lactulose is a synthetic sugar that reaches the colon unchanged, where intestinal bacteria break it down into short‑chain fatty acids. These acids increase the osmotic pressure in the colon, drawing water into the lumen, and they lower the colonic pH, converting ammonia to ammonium, which is trapped and eliminated, thereby reducing systemic ammonia.

The dose of Laevolac is individualized by the prescribing healthcare professional based on the patient’s age, weight, severity of constipation or hepatic encephalopathy, and response to therapy. No fixed regimen is provided here; the prescriber will set the appropriate dose and titration schedule.

Safety data for lactulose in pregnancy and lactation are limited. It is generally considered low risk because it is poorly absorbed, but clinicians should weigh potential benefits against any uncertain risks and discuss use with a qualified healthcare provider before starting treatment.

To request Laevolac, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Both lactulose and polyethylene glycol (PEG) act as osmotic agents, but lactulose also acidifies the colon and reduces ammonia absorption, making it useful for hepatic encephalopathy. PEG is inert and primarily used for constipation without the ammonia‑lowering effect. Choice depends on the clinical indication and patient tolerance.

Laevolac should be stored at ambient temperature, preferably below 25 °C. Keep the bottle tightly closed in its original packaging, protect it from moisture and direct sunlight, and discard any product that appears discolored or contains particles.

Laevolac is taken orally as a liquid solution. The prescribed volume is measured with a calibrated dosing device and ingested, usually once or twice daily, with or without food, according to the prescriber’s instructions.

Serious risks, although rare, include severe electrolyte disturbances such as hyponatremia or hypokalemia, marked dehydration from excessive diarrhea, and allergic reactions that may present as rash, urticaria or angioedema. Patients should seek medical attention promptly if any of these occur.

Laevolac should be avoided in patients with known hypersensitivity to lactulose, those with severe renal impairment where fluid balance is critical, and individuals with intestinal obstruction or perforation. Caution is also advised for patients with diabetes, as lactulose can affect blood glucose levels.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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