Product image of Laevolac (Lactulose, Liquid) supplied by GNH India

Laevolac

Active Ingredient:
Lactulose, Liquid
Origin:
EU

Laevolac (Lactulose, Liquid)

Lactulose, the active ingredient in Laevolac, is an osmotic laxative presented as a liquid for oral use. It works by drawing water into the colon to soften stools and by reducing ammonia absorption, making it useful for managing constipation and hepatic encephalopathy in both adult and pediatric patients under medical supervision.

GNH India supplies Laevolac as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable sourcing for this essential laxative and supporting patient care across diverse healthcare settings.

Manufacturer / TM Owner

Fresenius Kabi Austria Gmbh

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Indications & Clinical Uses

  • Laevolac (lactulose) is used as an osmotic laxative to manage conditions related to impaired bowel transit and elevated blood ammonia.
  • Constipation: softens stool and promotes regular bowel movements.
  • Hepatic encephalopathy: lowers intestinal ammonia production, helping to improve mental status.

How It Works

  • Lactulose is a synthetic disaccharide that is not absorbed in the small intestine. In the colon, bacterial enzymes hydrolyze it to short‑chain fatty acids, which increase osmotic pressure and draw water into the lumen. The resulting acidification lowers colonic pH, converting ammonia (NH3) to ammonium (NH4+), thereby reducing systemic absorption of ammonia. The increased luminal volume stimulates peristalsis, further facilitating stool passage.

Side Effects

Lactulose may cause gastrointestinal and metabolic reactions, most of which are mild and transient.

Common Side Effects

  • Flatulence: increased gas production in the colon.
  • Abdominal cramping: mild to moderate discomfort.
  • Diarrhea: loose stools, especially at higher doses.
  • Nausea: occasional feeling of queasiness.

Serious or Rare Side Effects

  • Electrolyte imbalance: severe diarrhea may lead to low potassium or sodium.
  • Dehydration: excessive fluid loss causing dizziness or low blood pressure.
  • Allergic reaction: rash, itching, swelling, or difficulty breathing.

Precautions & Warnings

When prescribing lactulose, clinicians should consider several safety measures to minimize risk.

  • Assess renal function: monitor in patients with kidney disease due to risk of electrolyte disturbances.
  • Evaluate hepatic status: use cautiously in severe liver failure.
  • Monitor fluid balance: ensure adequate hydration to prevent dehydration.
  • Adjust dose in pediatric patients: start with lower volume as directed by a pediatrician.
  • Avoid abrupt discontinuation: taper if long‑term use to prevent rebound constipation.
  • Store at ambient temperature: keep below 25 °C, in original container, protected from moisture and light.

Avoid Interactions

Lactulose can interact with certain medications and substances, affecting their absorption or efficacy.

Major Interactions (Avoid)

  • Antacids containing magnesium or aluminum: may reduce lactulose efficacy by binding in the gut.
  • Oral antibiotics: may alter colonic flora, decreasing lactulose conversion and effectiveness.

Moderate Interactions (Monitor Closely)

  • Diuretics: increased risk of electrolyte imbalance when combined with lactulose‑induced diarrhea.
  • Metformin: potential for additive gastrointestinal upset.
  • Phosphate binders: may interfere with lactulose’s osmotic action.

Frequently Asked Questions

Laevolac contains lactulose, an osmotic laxative indicated for the treatment of constipation and for reducing blood ammonia levels in patients with hepatic encephalopathy. It is prescribed by healthcare professionals for adult and pediatric patients who need gentle bowel cleansing or ammonia reduction under medical supervision.

Lactulose is a synthetic disaccharide that passes unchanged through the small intestine. In the colon, bacterial enzymes split it into short‑chain fatty acids, which increase osmotic pressure, draw water into the lumen, and lower pH. The acidic environment converts ammonia to ammonium, limiting its absorption and helping to soften stools.

The dose of Laevolac is individualized by the prescribing clinician based on the patient’s age, weight, severity of constipation or hepatic encephalopathy, and response to therapy. The healthcare provider determines the volume and frequency of the liquid preparation, and patients should follow the prescribed regimen exactly.

Safety data for lactulose in pregnancy and lactation are limited, and the product is classified as pregnancy category unknown. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To request Laevolac, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with stimulant laxatives, lactulose provides a gentler, osmotic mechanism that softens stool without causing abrupt intestinal contractions. It also offers the added benefit of reducing ammonia absorption, a feature not shared by most bulk‑forming agents. However, its onset of action may be slower, and it may be less effective for severe constipation requiring rapid evacuation.

Laevolac should be stored at ambient temperature, preferably below 25 °C (77 °F). Keep the bottle tightly closed, protect it from direct sunlight and moisture, and store it in its original packaging. Do not freeze the solution, and discard any product that appears discolored or has an off‑odor.

Laevolac is taken orally as a liquid. The prescribed volume is measured with a calibrated dosing device or syringe and consumed directly or mixed with a small amount of water or juice if needed for palatability. Doses are usually spaced several hours apart, and patients should maintain adequate fluid intake to support the osmotic effect.

The most serious risks include severe electrolyte disturbances such as hyponatremia or hypokalemia, dehydration from excessive diarrhea, and rare allergic reactions that may present as rash, swelling, or breathing difficulty. Patients experiencing persistent watery stools, dizziness, or signs of an allergic response should seek medical attention promptly.

Laevolac is contraindicated in individuals with known hypersensitivity to lactulose, those with intestinal obstruction, perforation, or severe inflammatory bowel disease. Caution is also advised for patients with uncontrolled diabetes, renal impairment, or severe liver failure, and it should be avoided in these populations unless a physician determines that the benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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