Product image of Lafleur (Dienogest, Estradiol Valerate) supplied by GNH India

Lafleur

Active Ingredient:
Dienogest, Estradiol Valerate
Origin:
EU

Lafleur (Dienogest, Estradiol Valerate)

Estradiol valerate and dienogest, the active ingredient in Lafleur, is a combined oral contraceptive presented as an oral tablet for oral use. It is indicated for contraception and for the management of endometriosis‑associated pain in women of reproductive age.

GNH India supplies Lafleur as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Dr. Kade Pharmazeutische Fabrik Gmbh

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Indications & Clinical Uses

Lafleur is a combined oral contraceptive that acts on the hormonal regulation of the menstrual cycle and provides pain relief in endometriosis.

  • Contraception: prevents pregnancy by inhibiting ovulation and altering cervical mucus.
  • Endometriosis‑associated pain: reduces pelvic pain by suppressing estrogen‑driven lesion activity.
  • Menstrual disorder management: helps regulate irregular bleeding and dysmenorrhea.

How It Works

  • Estradiol valerate provides estrogenic activity while dienogest supplies progestogenic activity. The estrogen component stabilizes the endometrial lining, and the progestogen suppresses the luteinizing hormone surge, preventing ovulation. Together they thicken cervical mucus and induce endometrial changes that reduce the likelihood of implantation.

Side Effects

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Headache: tension‑type or migraine‑like.
  • Breast tenderness: swelling or discomfort.
  • Spotting: irregular light bleeding.

Serious or Rare Side Effects

  • Venous thromboembolism: blood clots in deep veins.
  • Stroke: cerebrovascular accident due to clot formation.
  • Severe allergic reaction: anaphylaxis or angioedema.

Precautions & Warnings

Before prescribing Lafleur, consider the following precautions:

  • Cardiovascular risk assessment: evaluate history of thromboembolic events.
  • Smoking restriction: avoid use in women over 35 who smoke.
  • Blood pressure monitoring: watch for hypertension development.
  • Liver function review: contraindicated in severe hepatic disease.
  • Pregnancy testing: ensure patient is not pregnant before initiation.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Lafleur may interact with several medicines. Review patient medication lists carefully.

Major Interactions (Avoid)

  • Other estrogen‑containing products: increased clot risk.
  • Potent CYP3A4 inducers (e.g., rifampin): reduces contraceptive efficacy.
  • Anticoagulants (e.g., warfarin): may diminish anticoagulant effect.
  • Enzyme‑inducing antiepileptics (e.g., phenytoin): lower hormone levels.

Moderate Interactions (Monitor Closely)

  • Certain antibiotics (e.g., tetracycline): may slightly reduce effectiveness.
  • St. John’s wort: can decrease plasma hormone concentrations.
  • Antihypertensives: monitor blood pressure as contraceptives may affect control.

Frequently Asked Questions

Lafleur is a combined oral contraceptive containing estradiol valerate and dienogest. It is prescribed to prevent pregnancy and to manage pain associated with endometriosis, as well as to help regulate menstrual cycles in women of reproductive age.

Estradiol valerate provides estrogenic activity that stabilizes the endometrial lining, while dienogest acts as a progestogen to suppress the luteinizing hormone surge, preventing ovulation. The combination also thickens cervical mucus and induces endometrial changes that lower the chance of implantation.

The specific dosing regimen for Lafleur is determined by the prescribing healthcare professional based on the patient’s clinical needs and local guidelines. Patients should follow the prescriber’s instructions and not alter the dose on their own.

Lafleur is contraindicated during pregnancy because it is intended to prevent conception. Women who become pregnant should discontinue use immediately. Safety during breastfeeding has not been fully established; clinicians usually advise against use while nursing unless the benefits outweigh potential risks.

To place an order, submit an enquiry on the Lafleur product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lafleur combines estradiol valerate with dienogest, offering a specific estrogen‑progestogen balance that may provide better control of endometriosis‑related pain compared with some other formulations. Efficacy for contraception is comparable across combined oral contraceptives, while side‑effect profiles can vary based on the progestogen component.

Lafleur tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the product out of reach of children and avoid storing in bathrooms or other humid environments.

Lafleur is taken orally, usually once daily at the same time each day, as directed by the prescriber. The tablets are swallowed whole with water and should be taken with or without food according to the healthcare provider’s guidance.

Serious risks include venous thromboembolism, stroke, myocardial infarction, severe hypertension, and rare severe allergic reactions such as anaphylaxis. Patients should seek immediate medical attention if they experience symptoms like sudden chest pain, shortness of breath, severe headache, or swelling of the face or throat.

Lafleur is contraindicated in women with a history of thromboembolic disorders, uncontrolled hypertension, known or suspected breast cancer, severe liver disease, or those who are pregnant. It should also be avoided by smokers over the age of 35 and by individuals taking interacting medications that diminish its effectiveness.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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