Product image of Lafunomyl (Alfuzosin Hydrochloride) supplied by GNH India

Lafunomyl

Active Ingredient:
Alfuzosin Hydrochloride
Origin:
EU

Lafunomyl (Alfuzosin Hydrochloride)

Alfuzosin, the active ingredient in Lafunomyl, is an alpha‑1 adrenergic antagonist presented as an oral tablet for the treatment of benign prostatic hyperplasia (BPH) in adult men. It relaxes smooth muscle in the prostate, bladder neck and urethra, improving urinary flow and reducing lower urinary tract symptoms.

GNH India supplies Lafunomyl as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Viatris Limited

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Indications & Clinical Uses

Alfuzosin is used to manage lower urinary tract symptoms associated with benign prostatic hyperplasia.

  • Benign prostatic hyperplasia (BPH): improves urinary flow and reduces nocturia, urgency and weak stream.
  • Lower urinary tract symptoms (LUTS) due to BPH: alleviates frequency, hesitancy and incomplete emptying.
  • Acute urinary retention secondary to BPH: facilitates bladder emptying after catheter removal.

How It Works

  • Alfuzosin selectively blocks alpha‑1 adrenergic receptors located in the prostate, bladder neck and urethra. This antagonism prevents norepinephrine‑induced smooth‑muscle contraction, leading to relaxation of the urinary outflow tract and enhanced urine passage, thereby relieving obstruction caused by an enlarged prostate.

Side Effects

Alfuzosin may cause several adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Dizziness
  • Headache
  • Fatigue
  • Nasal congestion
  • Retrograde ejaculation
  • Gastrointestinal discomfort (nausea, abdominal pain)

Serious or Rare Side Effects

  • Severe hypotension or syncope
  • Priapism
  • Allergic reactions such as rash or angioedema
  • Cardiac arrhythmia
  • Prolonged QT interval (rare)
  • Hepatic dysfunction (rare)

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety aspects.

  • Blood pressure monitoring: check baseline and periodically during treatment.
  • Hepatic impairment: dose adjustment may be required in moderate to severe liver disease.
  • Concomitant antihypertensives: assess risk of additive blood‑pressure lowering.
  • Avoid abrupt discontinuation: may cause rebound urinary symptoms.
  • Review all concurrent medications for potential alpha‑blocker interactions.
  • Store at ambient temperature: keep below 25 °C, protect from moisture and light.

Avoid Interactions

Alfuzosin can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Other alpha‑blockers (e.g., tamsulosin, prazosin): risk of severe hypotension.
  • Potent CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): increase alfuzosin plasma levels.
  • Nitrates: additive vasodilatory effect leading to marked blood‑pressure drop.
  • Phosphodiesterase‑5 inhibitors combined with other alpha‑blockers: heightened risk of hypotension.

Moderate Interactions (Monitor Closely):\n- CYP3A4 inducers (e.g., rifampin): may reduce alfuzosin efficacy.

  • Diuretics: monitor electrolytes and blood pressure.
  • Other antihypertensive agents: dose adjustments may be necessary.

Frequently Asked Questions

Lafunomyl contains alfuzosin, which is prescribed to relieve symptoms of benign prostatic hyperplasia (BPH). It helps improve urinary flow, reduces nighttime urination, urgency and a weak stream, making it easier for men with an enlarged prostate to empty their bladder.

Alfuzosin selectively blocks alpha‑1 adrenergic receptors in the prostate, bladder neck and urethra. By preventing norepinephrine‑mediated muscle contraction, it relaxes the smooth muscle of the urinary outflow tract, decreasing obstruction and allowing urine to pass more freely.

The dose of Lafunomyl is determined by the prescribing clinician based on the patient’s condition, age, renal and hepatic function, and concomitant medications. Physicians typically start with a standard daily dose and may adjust it as needed, but the exact regimen should always follow the prescriber’s instructions.

Safety data for alfuzosin during pregnancy and lactation are limited. The product is generally not recommended for use in pregnant or nursing women unless the potential benefit justifies the potential risk, and such decisions should be made by a qualified healthcare professional.

To place an order, submit an enquiry on the Lafunomyl product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

The most common alternative to alfuzosin is tamsulosin, another selective alpha‑1 blocker. Both improve urinary flow, but alfuzosin has a slightly longer half‑life and may cause fewer sexual side effects such as retrograde ejaculation. Choice of therapy depends on individual patient response, tolerability and physician preference.

Lafunomyl tablets should be stored at ambient temperature, preferably below 25 °C. Keep the medication in its original container, protect it from moisture, excessive heat and direct sunlight to maintain potency throughout its shelf life.

Lafunomyl is taken orally, usually once daily with or without food, as directed by the prescribing physician. Swallow the tablet whole with a full glass of water and follow any specific timing instructions provided by the healthcare professional.

The most serious adverse events linked to alfuzosin include severe hypotension, syncope, priapism, and rare cardiac arrhythmias such as prolonged QT interval. Patients should be monitored for signs of low blood pressure, chest discomfort, or abnormal heart rhythms, and seek immediate medical attention if these occur.

Lafunomyl is contraindicated in patients with known hypersensitivity to alfuzosin or any component of the formulation. It should also be avoided in individuals taking concomitant alpha‑blockers, nitrates, or potent CYP3A4 inhibitors without medical supervision, as well as in patients with severe hepatic impairment unless dose adjustments are made.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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