Product image of Lakafin (Tioconazole) supplied by GNH India

Lakafin

Active Ingredient:
Tioconazole
Origin:
EU

Lakafin (Tioconazole)

Tioconazole, the active ingredient in Lakafin, is an imidazole antifungal presented as a topical formulation for external use. It treats superficial fungal infections, such as dermatophytosis and cutaneous candidiasis, by inhibiting fungal growth on the skin and mucous membranes of adult and pediatric patients.

GNH India supplies Lakafin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product complies with EU regulatory standards and is distributed across multiple international markets.

Manufacturer / TM Owner

Terix Labs Ltd

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Indications & Clinical Uses

  • Lakafin (tioconazole) is used to treat fungal conditions affecting the skin and mucous membranes.
  • Superficial fungal infections: reduces fungal colonization and promotes clearance of skin lesions.
  • Dermatophytosis: eliminates dermatophyte organisms, relieving itching and scaling.
  • Candidiasis: treats cutaneous and mucosal Candida infections, alleviating redness and discomfort.

How It Works

  • Tioconazole exerts its antifungal activity by inhibiting the fungal cytochrome P450 enzyme lanosterol 14α‑demethylase, a key step in ergosterol synthesis. Blocking this pathway disrupts the formation of ergosterol, an essential component of the fungal cell membrane, leading to increased membrane permeability and ultimately inhibiting fungal growth and replication.

Side Effects

Topical application of tioconazole may cause local skin reactions, ranging from mild irritation to rare severe responses.

Common Side Effects

  • Burning sensation: transient feeling of heat at the application site.
  • Itching: mild pruritus occurring after use.
  • Redness: localized erythema.
  • Dryness: skin dryness or flaking.

Serious or Rare Side Effects

  • Allergic contact dermatitis: rash, swelling, or hives indicating hypersensitivity.
  • Severe skin irritation: intense pain, blistering, or ulceration.
  • Anaphylaxis (rare): systemic allergic reaction requiring immediate medical attention.

Precautions & Warnings

When using Lakafin, several safety considerations should be observed to minimize adverse reactions and ensure effective treatment.

  • Avoid application on broken or inflamed skin: may increase irritation.
  • Do not apply to eyes, ears, or mucous membranes: product is for external use only.
  • Keep out of reach of children: accidental ingestion can cause harm.
  • Discontinue use if severe irritation or allergic reaction occurs: seek medical advice.
  • Consult a healthcare professional before use during pregnancy or breastfeeding: safety data are limited.
  • Store at room temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Tioconazole can interact with other topical agents or systemic antifungals, affecting absorption or irritation risk.

Major Interactions (Avoid)

  • Concurrent use with other imidazole or azole antifungal creams: may increase local irritation.
  • Use with systemic azole therapy (e.g., fluconazole) without medical guidance: potential additive systemic exposure.

Moderate Interactions (Monitor Closely)

  • Application together with topical corticosteroids: may mask signs of infection.
  • Use under occlusive dressings: can enhance drug absorption and irritation.
  • Combination with other skin irritants (e.g., harsh soaps, exfoliants): may increase discomfort.

Frequently Asked Questions

Lakafin contains tioconazole and is indicated for the treatment of superficial fungal infections of the skin and mucous membranes, including dermatophytosis (such as athlete’s foot, ringworm) and cutaneous or mucosal candidiasis.

Tioconazole inhibits the fungal enzyme lanosterol 14α‑demethylase, a key step in ergosterol synthesis. By blocking ergosterol production, the drug disrupts the fungal cell membrane, increasing its permeability and preventing fungal growth and replication.

The dosing regimen for Lakafin is determined by the prescribing healthcare professional. Typically, a thin layer is applied to the affected area once or twice daily for the duration recommended by the prescriber.

Safety of tioconazole topical use in pregnancy or lactation has not been definitively established. It should be used only if the potential benefit justifies any possible risk, and after consultation with a qualified healthcare provider.

To order Lakafin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Lakafin (tioconazole) belongs to the imidazole class and offers a broad spectrum against dermatophytes and Candida species. Compared with allylamine agents such as terbinafine, tioconazole may have a slightly slower onset but is effective for both dermatophytosis and candidiasis, making it a versatile topical option.

Store Lakafin at room temperature, preferably below 25 °C. Keep the product in its original container, protect it from moisture, direct sunlight and extreme temperatures to maintain stability.

Clean and dry the affected skin area before use. Apply a thin, even layer of Lakafin to the lesion and gently rub it in. Wash hands after application and avoid covering the treated area with occlusive dressings unless directed by a clinician.

The most serious risks include severe allergic reactions such as contact dermatitis, intense skin irritation, and, in rare cases, anaphylaxis. If any signs of systemic allergy (e.g., swelling, difficulty breathing) occur, seek immediate medical attention.

Individuals with a known hypersensitivity to tioconazole or any component of the formulation should avoid Lakafin. It should also not be applied to broken, inflamed or mucous membranes, and use in young children should be guided by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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