Product image of Lamal (Lamotrigine) supplied by GNH India

Lamal

Active Ingredient:
Lamotrigine
Origin:
EU

Lamal (Lamotrigine)

Lamotrigine, the active ingredient in Lamal, is an antiepileptic presented as an oral dosage form for oral use. It is indicated for partial seizures, generalized tonic‑clonic seizures, Lennox‑Gastaut syndrome, and as maintenance therapy for bipolar disorder. Lamal is manufactured for the EU market and complies with European regulatory standards.

GNH India supplies Lamal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Alkaloid D.O.O.

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Indications & Clinical Uses

Lamotrigine, marketed as Lamal, is used across several seizure disorders and mood stabilization pathways.

  • Partial seizures: reduces seizure frequency and severity.
  • Generalized tonic‑clonic seizures: helps achieve seizure control.
  • Lennox‑Gastaut syndrome: contributes to reduction of seizure episodes.
  • Bipolar disorder (maintenance therapy): stabilizes mood and prevents relapse.

How It Works

  • Lamotrigine inhibits voltage‑gated sodium channels, stabilizing neuronal membranes and decreasing the release of excitatory neurotransmitters such as glutamate. This modulation of neuronal excitability underlies its anticonvulsant and mood‑stabilizing effects, helping to prevent seizure propagation and mood swings.

Side Effects

Lamotrigine may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Dizziness
  • Headache
  • Nausea
  • Skin rash
  • Blurred vision
  • Insomnia

Serious or Rare Side Effects

  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Severe skin reactions (e.g., bullous rash)
  • Blood dyscrasias (e.g., agranulocytosis)
  • Hepatic failure
  • Suicidal thoughts or behavior
  • Severe hypersensitivity reactions

Precautions & Warnings

When prescribing Lamal, clinicians should consider several safety measures.

  • Monitor skin reactions: discontinue if rash progresses.
  • Adjust dose in hepatic impairment: start low and titrate cautiously.
  • Avoid abrupt discontinuation: taper to reduce seizure risk.
  • Use caution in pregnancy: limited data, weigh benefits vs risks.
  • Review concomitant enzyme‑inducing antiepileptics: may require dose adjustments.
  • Store below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Lamotrigine interacts with several medicines that can alter its plasma levels.

Major Interactions (Avoid)

  • Valproic acid: markedly increases lamotrigine concentrations.
  • Carbamazepine: significantly reduces lamotrigine levels.
  • Phenobarbital: lowers lamotrigine exposure.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: may decrease lamotrigine levels, requiring dose review.
  • Serotonergic agents (e.g., SSRIs): monitor for additive CNS effects.

Frequently Asked Questions

Lamal contains lamotrigine and is prescribed for partial seizures, generalized tonic‑clonic seizures, Lennox‑Gastaut syndrome, and as a maintenance therapy for bipolar disorder. These indications reflect its role as both an anticonvulsant and a mood stabilizer.

Lamotrigine blocks voltage‑gated sodium channels, which stabilizes neuronal membranes and reduces the release of excitatory neurotransmitters such as glutamate. This action diminishes neuronal hyper‑excitability, helping to prevent seizures and stabilize mood.

The dosage of Lamal is individualized by the prescribing clinician based on the patient’s condition, age, renal and hepatic function, and response to therapy. The prescriber determines the starting dose and any subsequent titration.

Safety data for lamotrigine in pregnancy and lactation are limited. Clinicians should weigh the potential benefits against possible risks, and discuss options with the patient. Breastfeeding decisions should also consider drug transfer into milk.

To order Lamal, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Compared with older antiepileptics such as carbamazepine or phenytoin, lamotrigine offers a broader spectrum covering both focal and generalized seizures and has mood‑stabilizing properties useful in bipolar disorder. Its side‑effect profile differs, with a lower risk of sedation but a notable risk of skin reactions.

Lamal should be stored below 25 °C in its original packaging, protected from moisture and direct sunlight. Maintaining these conditions helps preserve the tablet’s stability and potency throughout its shelf life.

Lamal is taken orally, usually as a tablet, with or without food. The exact dosing schedule—once or twice daily—depends on the prescriber’s plan and the patient’s therapeutic response.

The most serious risks include severe skin reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis, blood dyscrasias, hepatic failure, and the emergence of suicidal thoughts. Immediate medical attention is required if any of these occur.

Patients with a known hypersensitivity to lamotrigine or any component of the formulation should avoid Lamal. Caution is also advised for individuals with severe hepatic impairment, a history of serious skin reactions, or those taking interacting enzyme‑inducing drugs without proper dose adjustment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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