Product image of Lambutrix (Lorazepam) supplied by GNH India

Lambutrix

Active Ingredient:
Lorazepam
Origin:
EU

Lambutrix (Lorazepam)

Lorazepam, the active ingredient in Lambutrix, is a benzodiazepine presented as a sterile injectable solution for intramuscular and intravenous use. It treats anxiety disorders, provides pre‑operative sedation, and is employed in status epilepticus and short‑term insomnia management.

GNH India supplies Lambutrix as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Macure Healthcare Limited

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Indications & Clinical Uses

  • Lorazepam is indicated for several central nervous system conditions where modulation of GABA activity is therapeutic.
  • Anxiety disorders: reduces acute anxiety symptoms in adults.
  • Pre‑operative sedation: facilitates calmness and amnesia before surgery.
  • Status epilepticus: controls refractory seizure activity.
  • Insomnia (short‑term): promotes sleep onset for brief periods.

How It Works

  • Lorazepam binds to the benzodiazepine site on the GABA‑A receptor complex, enhancing the affinity of GABA for its receptor and increasing chloride ion influx. This potentiates inhibitory neurotransmission, leading to decreased neuronal excitability and producing anxiolytic, sedative, muscle‑relaxant, and anticonvulsant effects.

Side Effects

Lorazepam may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Drowsiness
  • Dizziness
  • Fatigue
  • Blurred vision
  • Weakness
  • Impaired coordination

Serious or Rare Side Effects

  • Respiratory depression
  • Severe hypotension
  • Paradoxical aggression or agitation
  • Anaphylactic reaction
  • Stevens‑Johnson syndrome
  • Suicidal ideation

Precautions & Warnings

  • When using Lorazepam, clinicians should consider several safety measures.
  • Pregnancy: use only if potential benefit justifies the risk.
  • Elderly patients: start with low dose and monitor for excessive sedation.
  • Abrupt discontinuation: taper gradually to avoid withdrawal.
  • Concomitant CNS depressants: increased risk of profound sedation and respiratory depression.
  • Renal or hepatic impairment: dose adjustment may be required.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Lorazepam interacts with various agents that can modify its sedative profile.

Major Interactions (Avoid)

  • Opioids: additive respiratory depression.
  • Alcohol: heightened CNS depression.
  • Other CNS depressants (e.g., barbiturates, antihistamines): increased sedation.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., ketoconazole): may raise lorazepam levels.
  • Antidepressants (e.g., SSRIs): potential for enhanced sedation or serotonin syndrome.

Frequently Asked Questions

Lambutrix contains lorazepam, a benzodiazepine used to manage anxiety disorders, provide pre‑operative sedation, treat status epilepticus, and aid short‑term insomnia under medical supervision.

Lorazepam enhances the activity of the neurotransmitter GABA at the GABA‑A receptor, increasing chloride ion flow into neurons, which reduces neuronal excitability and produces calming, sedative, muscle‑relaxant, and anticonvulsant effects.

The appropriate dose of Lambutrix is determined by the prescribing clinician based on the patient’s condition, age, weight, and response. Dosage regimens are individualized and should follow local prescribing guidelines.

Safety of lorazepam in pregnancy or while breastfeeding has not been fully established. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and under close medical supervision.

To order Lambutrix, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Lambutrix (lorazepam) offers a relatively long duration of action and a predictable pharmacokinetic profile compared with shorter‑acting agents like midazolam. Its potency and safety profile make it suitable for both acute anxiety relief and seizure control, though choice of agent depends on clinical context.

Lambutrix should be stored at 2‑8 °C, kept refrigerated, protected from light, and should not be frozen. Maintain the product in its original packaging to preserve stability.

Lambutrix is administered by a healthcare professional via intramuscular or intravenous injection, following aseptic technique. The route and rate of administration are determined by the clinical indication and patient condition.

Serious risks include respiratory depression, severe hypotension, paradoxical reactions such as aggression, anaphylaxis, and rare skin reactions like Stevens‑Johnson syndrome. Immediate medical attention is required if any of these occur.

Lambutrix is contraindicated in patients with known hypersensitivity to lorazepam or other benzodiazepines, those with acute narrow‑angle glaucoma, and individuals who are currently abusing alcohol or other CNS depressants without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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