Product image of Lambutrix (Lorazepam) supplied by GNH India

Lambutrix

Active Ingredient:
Lorazepam
Origin:
EU

Lambutrix (Lorazepam)

Lorazepam, the active ingredient in Lambutrix, is a benzodiazepine presented as an injectable solution for intramuscular and intravenous use. It is employed to manage anxiety disorders, provide pre‑operative sedation, control acute seizures, and treat short‑term insomnia in appropriate patients.
GNH India supplies Lambutrix as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Macure Healthcare Limited

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Indications & Clinical Uses

Lorazepam, a benzodiazepine that enhances GABA‑mediated inhibition, is indicated for several clinical situations.

  • Anxiety disorders: reduces excessive anxiety and tension.
  • Pre‑operative sedation: provides calming effect before surgical procedures.
  • Acute seizure control: terminates ongoing seizure activity.
  • Short‑term insomnia: facilitates sleep for a limited period.

How It Works

  • Lorazepam acts as a positive allosteric modulator at the GABA‑A receptor complex. By binding to a specific site, it increases the frequency of chloride channel opening in response to GABA, leading to enhanced neuronal hyperpolarization and reduced excitability throughout the central nervous system.

Side Effects

Common Side Effects

  • Drowsiness: feeling unusually sleepy.
  • Dizziness: light‑headed sensation.
  • Fatigue: reduced energy levels.
  • Impaired coordination: difficulty with fine motor tasks.

Serious or Rare Side Effects

  • Respiratory depression: slowed or shallow breathing.
  • Severe hypotension: marked drop in blood pressure.
  • Paradoxical agitation: unexpected increase in anxiety or aggression.
  • Dependence and withdrawal: risk of physical dependence with abrupt discontinuation.

Precautions & Warnings

Lorazepam requires careful consideration of patient‑specific factors and potential risks.

  • Pregnancy: use only if the potential benefit justifies the potential fetal risk.
  • Breastfeeding: caution advised as the drug may be excreted in breast milk.
  • Elderly patients: start with the lowest effective dose and monitor for excessive sedation.
  • Concomitant CNS depressants: avoid additive sedation and respiratory depression.
  • Renal or hepatic impairment: dose adjustment may be necessary.
  • Store at controlled room temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Lorazepam can interact with several drug classes, influencing its safety and efficacy.

Major Interactions (Avoid)

  • Opioids, barbiturates, alcohol: additive CNS depression.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): increased lorazepam levels.
  • Monoamine oxidase inhibitors (MAOIs): risk of severe hypotension.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampin, carbamazepine): reduced lorazepam effectiveness.
  • Antihistamines and certain antidepressants: may enhance sedative effects.

Frequently Asked Questions

Lambutrix contains lorazepam, a benzodiazepine used to treat anxiety disorders, provide pre‑operative sedation, control acute seizures, and manage short‑term insomnia when prescribed by a qualified healthcare professional.

Lorazepam enhances the activity of the neurotransmitter GABA at the GABA‑A receptor, increasing chloride ion influx into neurons. This results in greater inhibitory signaling, producing calming, anticonvulsant, and sedative effects.

The appropriate dose of Lambutrix is determined by the prescribing clinician based on the patient’s condition, age, weight, and response to therapy. Dosage regimens are individualized and should follow the prescriber’s instructions.

Lorazepam should be used during pregnancy only if the potential benefit outweighs the risk to the fetus. It is excreted in breast milk, so caution is advised for nursing mothers, and alternatives should be considered when possible.

To request Lambutrix, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Lambutrix (lorazepam) offers a relatively rapid onset of action and a moderate duration compared with agents such as diazepam (longer‑acting) or alprazolam (shorter‑acting). Its pharmacokinetic profile makes it suitable for acute anxiety, procedural sedation, and seizure emergencies.

Lambutrix should be stored at controlled room temperature, typically below 25 °C, in its original packaging. Protect the product from excessive light, moisture, and temperature fluctuations to maintain stability.

Lambutrix is supplied as an injectable solution for intramuscular or intravenous administration. The route, rate, and volume are determined by the healthcare professional based on the clinical indication and patient needs.

Serious risks include respiratory depression, severe hypotension, paradoxical agitation, and the potential for dependence and withdrawal symptoms if the drug is stopped abruptly after prolonged use. Immediate medical attention is required if any of these occur.

Lambutrix is contraindicated in patients with known hypersensitivity to lorazepam or other benzodiazepines, those with acute narrow‑angle glaucoma, and individuals taking potent CNS depressants where additive effects could be life‑threatening. Clinicians should evaluate each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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