Product image of Lametta (Letrozole) supplied by GNH India

Lametta

Active Ingredient:
Letrozole
Origin:
EU

Lametta (Letrozole)

Letrozole, the active ingredient in Lametta, is an aromatase inhibitor presented as an oral tablet for oral use. It is indicated for the treatment of postmenopausal estrogen receptor‑positive breast cancer, both as adjuvant and advanced‑disease therapy.

GNH India supplies Lametta as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Vipharm S.A.

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Indications & Clinical Uses

Letrozole acts on estrogen‑dependent breast cancer pathways, reducing tumor growth and recurrence.

  • Postmenopausal estrogen receptor‑positive breast cancer: provides adjuvant therapy to lower risk of disease recurrence.
  • Advanced hormone‑receptor positive breast cancer: inhibits tumor progression in metastatic settings.
  • Neoadjuvant breast cancer treatment: helps shrink tumors before surgical removal.

How It Works

  • Letrozole selectively inhibits the aromatase enzyme, which converts adrenal androgens into estrogens in peripheral tissues. By blocking this conversion, systemic estrogen levels fall, depriving estrogen‑dependent tumor cells of growth stimulation and thereby slowing or halting cancer progression.

Side Effects

Letrozole may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Hot flashes: sudden feeling of warmth and sweating.
  • Fatigue: persistent tiredness not relieved by rest.
  • Nausea: mild to moderate upset stomach.
  • Arthralgia: joint pain or stiffness.
  • Headache: mild to moderate intensity.
  • Increased sweating: excessive perspiration.

Serious or Rare Side Effects

  • Deep vein thrombosis: blood clot formation in deep veins.
  • Pulmonary embolism: clot migration to lungs.
  • Severe liver injury: marked elevation of hepatic enzymes.
  • Bone fracture: increased risk due to lowered estrogen.
  • Cardiac arrhythmia: rare QT‑interval prolongation.

Precautions & Warnings

Before initiating Letrozole therapy, several safety considerations should be reviewed.

  • Pregnancy contraindication: Category X; avoid use in pregnant women.
  • Liver function monitoring: assess hepatic enzymes periodically.
  • Bone health assessment: evaluate risk of osteoporosis or fractures.
  • Cardiovascular risk evaluation: consider history of thrombosis or heart disease.
  • Drug interaction review: check concomitant medications for potential interactions.
  • Store at ambient temperature: keep below 25°C in original packaging, protect from moisture.

Avoid Interactions

Letrozole can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Strong CYP2A6 inhibitors: may raise letrozole plasma levels.
  • Tamoxifen: concurrent use reduces therapeutic benefit of both agents.
  • Estrogen replacement therapy: antagonizes letrozole’s mechanism.

Moderate Interactions (Monitor Closely)

  • Warfarin: may increase anticoagulant effect and INR.
  • Antidiabetic drugs: potential alteration of glucose control.
  • Certain antidepressants: may enhance central nervous system side effects.

Frequently Asked Questions

Lametta contains letrozole, an aromatase inhibitor prescribed for postmenopausal women with estrogen receptor‑positive breast cancer. It is used as adjuvant therapy to reduce recurrence, as treatment for advanced disease, and in neoadjuvant settings to shrink tumors before surgery.

Letrozole blocks the aromatase enzyme, preventing the conversion of adrenal androgens into estrogen. Lowering circulating estrogen deprives hormone‑sensitive breast cancer cells of a key growth signal, thereby inhibiting tumor proliferation.

The dosage of letrozole is individualized by the prescribing physician based on clinical guidelines, patient characteristics, and treatment goals. The prescriber determines the appropriate strength, frequency, and duration of therapy.

Lametta is classified as Pregnancy Category X, meaning it is contraindicated in pregnant women because it can cause fetal harm. It is also not recommended during breastfeeding, as letrozole may be excreted in milk and affect the infant.

To request Lametta, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and necessary import documentation.

Letrozole belongs to the aromatase inhibitor class, which differs from selective estrogen receptor modulators like tamoxifen. Aromatase inhibitors generally provide stronger estrogen suppression in postmenopausal patients, offering improved disease‑free survival in many clinical trials, though side‑effect profiles vary.

Lametta should be stored at ambient temperature, below 25 °C. Keep the tablets in the original container, protect them from moisture and direct sunlight, and ensure they are out of reach of children.

Lametta is taken orally, usually as a tablet swallowed with water. The exact timing (e.g., with or without food) is determined by the prescribing clinician, but consistency in administration helps maintain stable drug levels.

Serious risks include deep vein thrombosis, pulmonary embolism, severe liver injury, bone fractures due to decreased estrogen, and rare cardiac arrhythmias. Patients should be monitored for signs of clotting, liver dysfunction, and bone health deterioration.

Lametta is contraindicated in pregnant women, individuals with known hypersensitivity to letrozole, and patients with severe liver impairment. Caution is also advised for those with a history of thromboembolic events, osteoporosis, or uncontrolled cardiovascular disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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